| 1351297 | EDARADD | EDAR associated via death domain | This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain recepto r known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] | 1 | 236348259 | 236484930 | Human | 240 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1558198 | Edaradd | EDAR associated via death domain | Predicted to enable death receptor binding activity. Acts upstream of or within hair follicle development; odontogenesis of dentin-containing tooth; and trachea gland development. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; metanephros; nari s; skin; and ureter. Human ortholog(s) of this gene implicated in ectodermal dysplasia 11A and ectodermal dysplasia 11B. Orthologous to human EDARADD (EDAR associated via death domain). [provided by Alliance of Genome Resources, Jul 2025] | 13 | 12486090 | 12535413 | Mouse | 146 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1564010 | Edaradd | EDAR associated via death domain | INVOLVED IN positive regulation of non-canonical NF-kappaB signal transduction; hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH abnormal awl hair morphology; abnormal hair texture; abnormal mammary gland alveolus morphology; ASSOCIATED WITH hypohidrotic ectodermal dysplasia; otitis media; ectodermal dysplasia (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 17beta-estradiol; bisphenol A; 1,2-dimethylhydrazine (ortholog) | 17 | 92850791 | 92894808 | Rat | 81 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8928726 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og) | NW_004955492 | 3709819 | 3777506 | Chinchilla | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11696464 | EDARADD | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | 1 | 211973108 | 212043142 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12106137 | EDARADD | EDAR associated death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | 4 | 3608545 | 3659357 | Dog | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12448215 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | NW_004936484 | 16394753 | 16446102 | Squirrel | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284812906 | edaradd | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18733119 | EDARADD | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Green Monkey | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921637 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625936109 | Edaradd | EDAR associated via death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14260764 | EDARADD | EDAR associated death domain | INVOLVED IN hair follicle development (ortholog); odontogenesis of dentin-containing tooth (ortholog); positive regulation of non-canonical NF-kappaB signal transduction (ortholog); ASSOCIATED WITH ectodermal dysplasia (ortholog); ectodermal dysplasia 10A (ortholog); ectodermal dysplasia 10B (orthol og); FOUND IN cytoplasm (inferred) | | | | Pig | 22 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 284673953 | edaradd.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359631 | edaradd.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14398765 | EdaraddswhKyo | EDAR-associated death domain;swh Kyo mutant | ASSOCIATED WITH abnormal awl hair morphology; abnormal hair texture; abnormal mammary gland alveolus morphology; ASSOCIATED WITH hypohidrotic ectodermal dysplasia | | | | Rat | 16 | symbol , description | gene, allele |
