| 1353395 | EBI3 | Epstein-Barr virus induced 3 | This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflam matory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008] | 19 | 4229523 | 4237528 | Human | 140 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1589467 | Ebi3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine receptor activity (ortholog); interleukin-27 receptor binding (ortholog); INVOLVED IN regulation of T cell proliferation (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH pre-eclampsia; asthma (orth olog); autism spectrum disorder (ortholog); FOUND IN extracellular region (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 861441 | 874731 | Rat | 126 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1615927 | Ebi3 | Epstein-Barr virus induced gene 3 | Enables interleukin-27 receptor binding activity. Involved in T cell proliferation. Predicted to be located in extracellular space and membrane. Is expressed in several structures, including decidua; extraembryonic component; sensory organ; and skeleton. Orthologous to human EBI3 :700;'>EBI3 (Epstein-Barr virus induced 3). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 56259623 | 56264022 | Mouse | 168 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8758162 | Ebi3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine receptor activity (ortholog); interleukin-27 receptor binding (ortholog); INVOLVED IN regulation of T cell proliferation (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism s pectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region (ortholog); interleukin-35 complex (ortholog); receptor complex (ortholog) | NW_004955495 | 4609841 | 4615686 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11720195 | EBI3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits interleukin-27 receptor binding (ortholog); INVOLVED IN T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region ( inferred); membrane (inferred) | 19 | 3252194 | 3266893 | Bonobo | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12390342 | EBI3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor activity (inferred); INVOLVED IN cytokine-mediated signaling pathway (inferred); immune system process (inferred); regulation of T cell proliferation (inferred); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIAT ED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); membrane (inferred) | 20 | 55382975 | 55391252 | Dog | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12645531 | Ebi3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor activity (inferred); interleukin-27 receptor binding (inferred); INVOLVED IN cytokine-mediated signaling pathway (inferred); immune system process (inferred); regulation of T cell proliferation (inferred); PARTICIPATES I N interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); membrane (inferred) | NW_004936588 | 2420859 | 2425473 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255146 | ebi3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 39131512 | EBI3 | Epstein-Barr virus induced 3 | | | | | Chinchilla | | symbol | gene, protein-coding |
| 14203905 | EBI3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor activity (inferred); INVOLVED IN cytokine-mediated signaling pathway (inferred); immune system process (inferred); regulation of T cell proliferation (inferred); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIAT ED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); membrane (inferred) | | | | Pig | 23 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18497465 | EBI3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits interleukin-27 receptor binding (ortholog); INVOLVED IN T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region ( inferred); extracellular space (inferred); membrane (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626048812 | Ebi3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits cytokine receptor activity (ortholog); interleukin-27 receptor binding (ortholog); INVOLVED IN regulation of T cell proliferation (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism s pectrum disorder (ortholog); pre-eclampsia (ortholog); FOUND IN extracellular region (ortholog); interleukin-35 complex (ortholog); receptor complex (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18904356 | Ebi3 | Epstein-Barr virus induced 3 | ENCODES a protein that exhibits interleukin-27 receptor binding (ortholog); INVOLVED IN regulation of T cell proliferation (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH asthma (ortholog); autism spectrum disorder (ortholog); pre-eclamp sia (ortholog); FOUND IN interleukin-35 complex (ortholog); receptor complex (ortholog) | | | | Naked Mole-Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245028 | ebi3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 736484 | SQSTM1 | sequestosome 1 | This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to ups tream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009] | 5 | 179806393 | 179838078 | Human | 1734 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1343577 | IL27 | interleukin 27 | The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008] | 16 | 28499362 | 28506834 | Human | 183 | description | gene, protein-coding, REVIEWED [RefSeq] |