| 1310721 | Dusp16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits JUN kinase binding (ortholog); mitogen-activated protein kinase binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kina ses MAPK signaling pathway; p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; ASSOCIATED WITH transient cerebral ischemia; Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine | 4 | 169278118 | 169361508 | Rat | 166 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321793 | DUSP16 | dual specificity phosphatase 16 | This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specific ally regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010] | 12 | 12473282 | 12562863 | Human | 168 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1620783 | Dusp16 | dual specificity phosphatase 16 | Predicted to enable phosphoprotein phosphatase activity; protein carrier chaperone; and protein kinase binding activity. Predicted to be involved in dephosphorylation; negative regulation of MAPK cascade; and signal transduction. Predicted to be located in nucleoplasm. Predicted to be active in cyto plasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP16 (dual specificity phosphatase 16). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 134692431 | 134769687 | Mouse | 187 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8886566 | Dusp16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits JUN kinase binding (ortholog); mitogen-activated protein kinase binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kina ses MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | NW_004955413 | 9404259 | 9481061 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11795601 | DUSP16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway ; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 12 | 12497185 | 12585591 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12200513 | DUSP16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | 27 | 33728209 | 33831258 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12459587 | Dusp16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway ; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | NW_004936587 | 4711085 | 4801030 | Squirrel | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18372943 | DUSP16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway ; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14088896 | DUSP16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine/serine/threonine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625832254 | Dusp16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits JUN kinase binding (ortholog); mitogen-activated protein kinase binding (ortholog); mitogen-activated protein kinase p38 binding (ortholog); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kina ses MAPK signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (ortholog); nucleoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18914383 | Dusp16 | dual specificity phosphatase 16 | ENCODES a protein that exhibits hydrolase activity (inferred); JUN kinase binding (inferred); MAP kinase tyrosine phosphatase activity (inferred); INVOLVED IN dephosphorylation (ortholog); negative regulation of MAPK cascade (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway ; p38 MAPK signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); transient cerebral ischemia (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238816 | dusp16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155238815 | dusp16.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251741 | dusp16.S | | | | | | African Clawed Frog | | symbol | gene, null |