| 1311767 | Dtx4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of innate immune response (ortholog); proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Notch si gnaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,4-dinitrotoluene | 1 | 218882391 | 218969837 | Rat | 138 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323395 | DTX4 | deltex E3 ubiquitin ligase 4 | Enables ubiquitin protein ligase activity. Involved in negative regulation of innate immune response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Is active in centrosome. [provided by Alliance of Genome Resources, Jul 2025] | 11 | 59171430 | 59208588 | Human | 138 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1323396 | Dtx4 | deltex 4, E3 ubiquitin ligase | Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including Notch signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be act ive in centrosome and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 12443700 | 12479509 | Mouse | 152 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8960538 | Dtx4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of innate immune response (ortholog); proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (ortholog) | NW_004955511 | 3758631 | 3782560 | Chinchilla | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12009256 | DTX4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (inferred); Notch signaling pathway (inferred); proteasomal protein catabolic process (inferred); ASS OCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred) | 11 | 54389228 | 54425655 | Bonobo | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12107441 | DTX4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (inferred); Notch signaling pathway (inferred); proteasomal protein catabolic process (inferred); ASS OCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred) | 18 | 37535957 | 37570937 | Dog | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12539296 | Dtx4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (inferred); Notch signaling pathway (inferred); proteasomal protein catabolic process (inferred); ASS OCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred) | NW_004936581 | 3433760 | 3467863 | Squirrel | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 13981669 | DTX4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (inferred); Notch signaling pathway (inferred); proteasomal protein catabolic process (inferred); ASS OCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 27 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 284887158 | dtx4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625945634 | Dtx4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of innate immune response (ortholog); proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (ortholog) | | | | Black Rat | 8 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18916743 | Dtx4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (ortholog); proteasomal protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (ortholog) | | | | Naked Mole-Rat | 20 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18609979 | DTX4 | deltex E3 ubiquitin ligase 4 | ENCODES a protein that exhibits metal ion binding (inferred); transferase activity (inferred); ubiquitin protein ligase activity (inferred); INVOLVED IN negative regulation of innate immune response (inferred); Notch signaling pathway (inferred); proteasomal protein catabolic process (inferred); ASS OCIATED WITH adenoid cystic carcinoma (ortholog); pancreatic ductal carcinoma (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred) | | | | Green Monkey | 22 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |