| 735051 | Dstyk | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholo g); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 13 | 46409412 | 46457426 | Rat | 122 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1551598 | Dstyk | dual serine/threonine and tyrosine protein kinase | Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in several processes, including cellular response to fibroblast growth factor stimulus; positive regulation of kinase activity; and positive regulation of signal transduction. Located in apical plasma memb rane; basolateral plasma membrane; and cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and skin. Human ortholog(s) of this gene implicated in CAKUT1 and hereditary spastic paraplegia 23. Orthologous to human DSTYK (dual serine/threonine and tyrosine protein kinase). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 132345127 | 132394697 | Mouse | 112 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1604373 | DSTYK | dual serine/threonine and tyrosine protein kinase | This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] | 1 | 205142505 | 205211702 | Human | 151 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8934547 | Dstyk | dual serine/threonine and tyrosine protein kinase | INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog) | NW_004955406 | 40922972 | 40971433 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12017627 | DSTYK | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN positive regulation of kinase activity (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN a nchoring junction (inferred); apical plasma membrane (inferred); basolateral plasma membrane (inferred) | 1 | 180750987 | 180820096 | Bonobo | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12264134 | DSTYK | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholo g); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog); INTERACTS WITH bisphenol A | 38 | 1669721 | 1716407 | Dog | 46 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12534694 | Dstyk | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN positive regulation of kinase activity (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN a nchoring junction (inferred); apical plasma membrane (inferred); basolateral plasma membrane (inferred) | NW_004936557 | 7191377 | 7243489 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930105 | Dstyk | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN positive regulation of kinase activity (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN a nchoring junction (inferred); apical plasma membrane (inferred); basolateral plasma membrane (inferred) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18642400 | DSTYK | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN positive regulation of kinase activity (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN a nchoring junction (inferred); apical plasma membrane (inferred); basolateral plasma membrane (inferred) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240418 | dstyk | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13870085 | DSTYK | dual serine/threonine and tyrosine protein kinase | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN positive regulation of kinase activity (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN a nchoring junction (inferred); apical plasma membrane (inferred); basolateral plasma membrane (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626161546 | Dstyk | dual serine/threonine and tyrosine protein kinase | INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH CAKUT1 (ortholog); chronic kidney disease (ortholog); hereditary spastic paraplegia (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626172837 | dstyk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857854 | dstyk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862807 | dstyk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857315 | dstyk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857554 | dstyk.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250660 | dstyk.S | | | | | | African Clawed Frog | | symbol | gene, null |