DSTYK (dual serine/threonine and tyrosine protein kinase) - Rat Genome Database

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Gene: DSTYK (dual serine/threonine and tyrosine protein kinase) Canis lupus familiaris
Analyze
Symbol: DSTYK
Name: dual serine/threonine and tyrosine protein kinase
RGD ID: 12264134
Description: ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); nucleotide binding (inferred); INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); negative regulation of apoptotic process (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH autistic disorder (ortholog); CAKUT1 (ortholog); chronic kidney disease (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dusty PK; dusty protein kinase; receptor interacting protein kinase 5; receptor-interacting serine/threonine-protein kinase 5; RIPK5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,669,721 - 1,716,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,669,726 - 1,716,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,763,642 - 1,810,363 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,666,218 - 1,712,910 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,666,223 - 1,712,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,662,282 - 1,708,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,053,438 - 2,100,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,253,623 - 2,300,336 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:17123648   PMID:22301074  


Genomics

Comparative Map Data
DSTYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,669,721 - 1,716,407 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,669,726 - 1,716,254 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha381,763,642 - 1,810,363 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0381,666,218 - 1,712,910 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,666,223 - 1,712,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,662,282 - 1,708,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,053,438 - 2,100,433 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,253,623 - 2,300,336 (-)NCBIUU_Cfam_GSD_1.0
DSTYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381205,142,505 - 205,211,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1205,142,505 - 205,211,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371205,111,633 - 205,180,830 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,378,256 - 203,447,313 (-)NCBINCBI36Build 36hg18NCBI36
Celera1178,246,858 - 178,315,803 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1176,276,947 - 176,346,439 (-)NCBIHuRef
CHM1_11206,534,987 - 206,604,027 (-)NCBICHM1_1
T2T-CHM13v2.01204,406,864 - 204,475,975 (-)NCBIT2T-CHM13v2.0
Dstyk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,345,127 - 132,394,697 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,345,293 - 132,394,696 (+)EnsemblGRCm39 Ensembl
GRCm381132,417,389 - 132,466,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,417,555 - 132,466,958 (+)EnsemblGRCm38mm10GRCm38
MGSCv371134,314,030 - 134,363,536 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361134,245,114 - 134,294,504 (+)NCBIMGSCv36mm8
Celera1135,024,440 - 135,073,889 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.24NCBI
Dstyk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,409,412 - 46,457,426 (+)NCBIGRCr8
mRatBN7.21343,857,266 - 43,905,280 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,857,266 - 43,905,269 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1346,464,262 - 46,512,270 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,752,400 - 47,800,402 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,013,095 - 45,061,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,195,325 - 49,243,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,195,325 - 49,243,316 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01354,263,966 - 54,318,738 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41345,309,935 - 45,357,932 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11345,323,977 - 45,371,970 (+)NCBI
Celera1344,191,910 - 44,239,861 (+)NCBICelera
Cytogenetic Map13q13NCBI
Dstyk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,922,972 - 40,971,582 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,922,972 - 40,971,433 (-)NCBIChiLan1.0ChiLan1.0
DSTYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2144,155,916 - 44,227,819 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1144,121,218 - 44,193,086 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01180,750,987 - 180,820,096 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,036,950 - 185,107,039 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,041,994 - 185,107,041 (-)Ensemblpanpan1.1panPan2
Dstyk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,951,108 - 70,003,213 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365577,191,082 - 7,239,816 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365577,191,377 - 7,243,489 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DSTYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,833,054 - 65,891,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1965,833,050 - 65,892,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2972,057,975 - 72,117,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DSTYK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,128,889 - 24,200,115 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,128,899 - 24,195,085 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605524,885,185 - 24,955,720 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dstyk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248075,942,799 - 5,993,049 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248075,942,610 - 5,993,049 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DSTYK
560 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 15 1 6 12 8 10
Low 2 5 7 6 5 6 6 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000015918   ⟹   ENSCAFP00000014726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl381,669,726 - 1,716,254 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000093394   ⟹   ENSCAFP00000043319
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl381,669,726 - 1,708,823 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045667   ⟹   ENSCAFP00845035833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl381,666,223 - 1,712,757 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845045803   ⟹   ENSCAFP00845035955
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl381,666,223 - 1,712,757 (-)Ensembl
RefSeq Acc Id: NM_001025268   ⟹   NP_001020439
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1381,669,721 - 1,716,407 (-)NCBI
Dog10K_Boxer_Tasha381,763,642 - 1,810,363 (-)NCBI
ROS_Cfam_1.0381,666,218 - 1,712,910 (-)NCBI
UMICH_Zoey_3.1381,662,282 - 1,708,976 (-)NCBI
UNSW_CanFamBas_1.0382,053,438 - 2,100,433 (-)NCBI
UU_Cfam_GSD_1.0382,253,623 - 2,300,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038448125   ⟹   XP_038304053
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0381,666,236 - 1,712,104 (-)NCBI
RefSeq Acc Id: NP_001020439   ⟸   NM_001025268
- UniProtKB: Q4VSN4 (UniProtKB/Swiss-Prot),   A0A8P0SF32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014726   ⟸   ENSCAFT00000015918
RefSeq Acc Id: ENSCAFP00000043319   ⟸   ENSCAFT00000093394
RefSeq Acc Id: XP_038304053   ⟸   XM_038448125
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVT1 (UniProtKB/TrEMBL),   A0A8C0JYN5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845035833   ⟸   ENSCAFT00845045667
RefSeq Acc Id: ENSCAFP00845035955   ⟸   ENSCAFT00845045803
Protein Domains
Protein kinase

Promoters
RGD ID:13689178
Promoter ID:EPDNEW_C7247
Type:single initiation site
Name:DSTYK_1
Description:dual serine/threonine and tyrosine protein kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1381,716,281 - 1,716,341EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009999 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009843 UniProtKB/TrEMBL
  ENSCAFG00040017034 UniProtKB/TrEMBL
  ENSCAFG00845025761 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015918.5 UniProtKB/TrEMBL
  ENSCAFT00000093394.2 UniProtKB/TrEMBL
  ENSCAFT00000101041.1 UniProtKB/TrEMBL
  ENSCAFT00030018664.1 UniProtKB/TrEMBL
  ENSCAFT00040032166.1 UniProtKB/TrEMBL
  ENSCAFT00040032254.1 UniProtKB/TrEMBL
  ENSCAFT00845045667 ENTREZGENE
  ENSCAFT00845045667.1 UniProtKB/TrEMBL
  ENSCAFT00845045803.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:478942 UniProtKB/Swiss-Prot
NCBI Gene DSTYK ENTREZGENE
PANTHER DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE UniProtKB/Swiss-Prot
  DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE UniProtKB/Swiss-Prot
  DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SERINE/THREONINE AND TYROSINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JVT1 ENTREZGENE
  A0A8C0JYN5 ENTREZGENE
  A0A8C0SXA4_CANLF UniProtKB/TrEMBL
  A0A8C0Z0Q6_CANLF UniProtKB/TrEMBL
  A0A8I3PMA4_CANLF UniProtKB/TrEMBL
  A0A8I3PWQ7_CANLF UniProtKB/TrEMBL
  A0A8P0NTS1_CANLF UniProtKB/TrEMBL
  A0A8P0SF32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TLG1_CANLF UniProtKB/TrEMBL
  DUSTY_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:54269 ENTREZGENE