| 1306677 | Dock3 | dedicator of cyto-kinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene | 8 | 116431158 | 116782218 | Rat | 85 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1315429 | DOCK3 | dedicator of cytokinesis 3 | This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010] | 3 | 50674927 | 51384198 | Human | 129 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1315430 | Dock3 | dedicator of cyto-kinesis 3 | Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in attention def icit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 106770024 | 107109108 | Mouse | 102 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8920304 | Dock3 | dedicator of cytokinesis 3 | ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955532 | 2616700 | 3073926 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11693524 | DOCK3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); small GTPase binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Develop mental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred) | 3 | 50603069 | 51314876 | Bonobo | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12367605 | DOCK3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 20 | 38200938 | 38707310 | Dog | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12491730 | Dock3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred) | NW_004936529 | 2182261 | 2771107 | Squirrel | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626019801 | Dock3 | dedicator of cytokinesis 3 | ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18908325 | Dock3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13958034 | DOCK3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254268 | dock3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18676909 | DOCK3 | dedicator of cytokinesis 3 | ENCODES a protein that exhibits GTPase activator activity (inferred); guanyl-nucleotide exchange factor activity (inferred); SH3 domain binding (inferred); INVOLVED IN small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH attention deficit hyperactivity disorder (ortholog); Developme ntal Disabilities (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405860995 | dock3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626180235 | dock3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862113 | dock3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860516 | dock3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859324 | dock3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862834 | dock3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861026 | dock3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469785 | dock3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856897 | dock3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865131 | dock3.S | | | | | | African Clawed Frog | | symbol | gene, null |
