| 620669 | Dnase1l3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding; DNA endonuclease activity; endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); DNA catabolic process (ortholog); neutrophil activation involved in immune response (ortholog); ASSOCIATED WITH genetic disease (ortholog); he patocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog); nucleus (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil; acetamide | 15 | 19351683 | 19378536 | Rat | 147 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733865 | DNASE1L3 | deoxyribonuclease 1L3 | This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding m ultiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] | 3 | 58192257 | 58210972 | Human | 210 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733866 | Dnase1l3 | deoxyribonuclease 1-like 3 | Enables endonuclease activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Acts upstream of or within apoptotic DNA fragmentation and programmed cell death involved in cell deve lopment. Located in nucleus. Orthologous to human DNASE1L3 (deoxyribonuclease 1L3). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 14475014 | 14504586 | Mouse | 155 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9024321 | Dnase1l3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); DNA catabolic process (ortholog); neutrophil activation involved in immune response (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog); nucleus (ortholog) | NW_004955430 | 7867172 | 7892079 | Chinchilla | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12035516 | DNASE1L3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neopl asms (ortholog); FOUND IN endoplasmic reticulum (inferred); nucleus (inferred) | 3 | 58127491 | 58146177 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12115207 | DNASE1L3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neopl asms (ortholog); FOUND IN endoplasmic reticulum (inferred); nucleus (inferred) | 20 | 32350138 | 32379240 | Dog | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12682307 | Dnase1l3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neopl asms (ortholog); FOUND IN endoplasmic reticulum (inferred); nucleus (inferred) | NW_004936473 | 8430235 | 8495170 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18372334 | DNASE1L3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); neutrophil activation involved in immune response (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disea se (ortholog); hepatocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (inferred); nucleus (inferred) | | | | Green Monkey | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910706 | Dnase1l3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); neutrophil activation involved in immune response (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disea se (ortholog); hepatocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14120542 | DNASE1L3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); programmed cell death involved in cell development (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neopl asms (ortholog); FOUND IN endoplasmic reticulum (inferred); nucleus (inferred) | | | | Pig | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155251506 | dnase1l3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626031644 | Dnase1l3 | deoxyribonuclease 1L3 | ENCODES a protein that exhibits DNA binding (ortholog); DNA endonuclease activity (ortholog); endonuclease activity (ortholog); INVOLVED IN apoptotic DNA fragmentation (ortholog); DNA catabolic process (ortholog); neutrophil activation involved in immune response (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); Lung Neoplasms (ortholog); FOUND IN endoplasmic reticulum (ortholog); nucleus (ortholog) | | | | Black Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405861992 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860075 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863426 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626179062 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182259 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856180 | dnase1l3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253293 | dnase1l3.S | | | | | | African Clawed Frog | | symbol | gene, null |