| 1304875 | Dlx3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN blood vessel development (ortholog); BMP signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH am elogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol | 10 | 80561335 | 80566730 | Rat | 134 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312567 | DLX3 | distal-less homeobox 3 | Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing frui t fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008] | 17 | 49990005 | 49995224 | Human | 220 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312568 | Dlx3 | distal-less homeobox 3 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell surface receptor signaling pathway; epithelial cell differen tiation; and hair follicle cell proliferation. Acts upstream of or within blood vessel development; odontogenesis of dentin-containing tooth; and placenta development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 95010943 | 95016122 | Mouse | 147 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8845043 | Dlx3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN blood vessel development (ortholog); BMP signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH am elogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | NW_004955451 | 11635027 | 11640091 | Chinchilla | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11994592 | DLX3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN blood vessel development (ortholog); odontoblast differentiation (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 17 | 44076437 | 44081690 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12187639 | DLX3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN blood vessel development (ortholog); odontoblast differentiation (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | 9 | 26018101 | 26022964 | Dog | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12491325 | Dlx3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN blood vessel development (ortholog); odontoblast differentiation (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | NW_004936490 | 11625862 | 11630035 | Squirrel | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18933192 | Dlx3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN blood vessel development (ortholog); BMP signaling pathway (ortholog); gene express ion (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (ortholog) | | | | Naked Mole-Rat | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247108 | dlx3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18368075 | DLX3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN blood vessel development (ortholog); odontoblast differentiation (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626052401 | Dlx3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN blood vessel development (ortholog); BMP signaling pathway (ortholog); gene expression (ortholog); ASSOCIATED WITH am elogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Black Rat | 36 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14208677 | DLX3 | distal-less homeobox 3 | ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN blood vessel development (ortholog); odontoblast differentiation (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 4 (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Pig | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252074 | dlx3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249915 | dlx3.S | | | | | | African Clawed Frog | | symbol | gene, null |