| 1309740 | Dll4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits Notch binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN cellular response to cholesterol; cellular response to hypoxia; chondrocyte differentiation; PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH Burns; Choroidal N eovascularization; Choroidal Neovascularization, Experimental; FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 3 | 126770945 | 126780769 | Rat | 265 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320241 | DLL4 | delta like canonical Notch ligand 4 | This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] | 15 | 40929340 | 40939073 | Human | 399 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320242 | Dll4 | delta like canonical Notch ligand 4 | Enables Notch binding activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and regulation of Notch signaling pathway. Acts upstream of or within several processes, including Notch signaling pathway; angiogenesis; and negative regulation of blood vessel endothelial cell migration. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; intestine; and retina. Used to study Adams-Oliver syndrome. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and limb ischemia. Orthologous to human DLL4 (delta like canonical Notch ligand 4). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 119156286 | 119166145 | Mouse | 339 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8753307 | Dll4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits Notch binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN angiogenesis (ortholog); aortic valve morphogenesis (ortholog); blood vessel lumenization (ortholog); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH acute kid ney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog) | NW_004955416 | 7807049 | 7816346 | Chinchilla | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12027488 | DLL4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATE D WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); protein-containing complex (inferred) | 15 | 19871584 | 19881817 | Bonobo | 107 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12338198 | DLL4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATE D WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | 30 | 8059463 | 8068742 | Dog | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12664259 | Dll4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATE D WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | NW_004936471 | 4320235 | 4330251 | Squirrel | 114 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913761 | Dll4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; Notch sig naling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); protein-containing complex (inferred) | | | | Naked Mole-Rat | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252659 | dll4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18710913 | DLL4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; Notch sig naling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 110 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14247956 | DLL4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; Notch sig naling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred); plasma membrane (inferred) | | | | Pig | 118 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626062904 | Dll4 | delta like canonical Notch ligand 4 | ENCODES a protein that exhibits Notch binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN angiogenesis (ortholog); aortic valve morphogenesis (ortholog); blood vessel lumenization (ortholog); PARTICIPATES IN Notch signaling pathway; Notch signaling pathway; ASSOCIATED WITH acute kid ney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog) | | | | Black Rat | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235715 | dll4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626179693 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858910 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626177363 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864924 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859501 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858348 | dll4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1624674 | Gm14207 | predicted gene 14207 | | 2 | 119151680 | 119156678 | Mouse | 3 | old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 9076375 | Dll4l1 | delta like canonical Notch ligand 4 like 1 | | 3 | 126765302 | 126771805 | Rat | | symbol , old_gene_name , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
