DLL4 (delta like canonical Notch ligand 4) - Rat Genome Database

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Gene: DLL4 (delta like canonical Notch ligand 4) Canis lupus familiaris
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Symbol: DLL4
Name: delta like canonical Notch ligand 4
RGD ID: 12338198
Description: ENCODES a protein that exhibits calcium ion binding (inferred); Notch binding (inferred); receptor ligand activity (inferred); INVOLVED IN angiogenesis (ortholog); cellular response to cholesterol (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Adams-Oliver syndrome (ortholog); Adams-Oliver Syndrome 6 (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: delta-like protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,059,463 - 8,068,742 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,059,512 - 8,067,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,114,087 - 8,123,649 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,188,070 - 8,197,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,185,217 - 8,197,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,111,270 - 8,120,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,217,668 - 8,227,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,349,053 - 8,358,618 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
aortic valve morphogenesis  (IEA)
blood vessel lumenization  (IEA)
blood vessel remodeling  (IEA)
branching involved in blood vessel morphogenesis  (IEA)
cardiac atrium morphogenesis  (IEA)
cardiac ventricle morphogenesis  (IEA)
cell communication  (IEA)
cellular response to cholesterol  (ISO)
cellular response to fibroblast growth factor stimulus  (IEA)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
chondrocyte differentiation  (ISO)
developmental process  (IEA)
dorsal aorta morphogenesis  (IEA)
luteolysis  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of endothelial cell migration  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of Notch signaling pathway  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
Notch signaling pathway  (IEA,ISO)
pericardium morphogenesis  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of neural precursor cell proliferation  (IEA)
positive regulation of Notch signaling pathway  (IEA)
regulation of neural retina development  (IEA)
regulation of neurogenesis  (IEA,ISO)
T cell differentiation  (IEA)
ventral spinal cord interneuron fate commitment  (IEA)
ventricular trabecula myocardium morphogenesis  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DLL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,059,463 - 8,068,742 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,059,512 - 8,067,940 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,114,087 - 8,123,649 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,188,070 - 8,197,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,185,217 - 8,197,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,111,270 - 8,120,832 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,217,668 - 8,227,235 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,349,053 - 8,358,618 (+)NCBIUU_Cfam_GSD_1.0
DLL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,929,340 - 40,939,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,929,340 - 40,939,073 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,221,538 - 41,231,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,008,839 - 39,018,529 (+)NCBINCBI36Build 36hg18NCBI36
Build 341539,008,838 - 39,018,529NCBI
Celera1517,989,410 - 17,999,137 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,070,066 - 18,079,793 (+)NCBIHuRef
CHM1_11541,339,420 - 41,349,204 (+)NCBICHM1_1
T2T-CHM13v2.01538,735,323 - 38,745,058 (+)NCBIT2T-CHM13v2.0
Dll4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,156,286 - 119,166,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,156,265 - 119,166,443 (+)EnsemblGRCm39 Ensembl
GRCm382119,325,784 - 119,335,666 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,325,784 - 119,335,962 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,151,520 - 119,161,402 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,017,270 - 119,027,097 (+)NCBIMGSCv36mm8
Celera2120,476,206 - 120,486,045 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Dll4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,770,945 - 126,780,769 (+)NCBIGRCr8
mRatBN7.23106,317,114 - 106,327,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,316,986 - 106,326,931 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,990,303 - 110,000,143 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,585,843 - 118,595,685 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,246,228 - 116,256,068 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,135,011 - 111,146,746 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,135,021 - 111,145,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,685,724 - 117,695,772 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,844,671 - 105,854,738 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,741,099 - 105,750,240 (+)NCBI
Celera3105,230,387 - 105,240,148 (+)NCBICelera
Cytogenetic Map3q35NCBI
Dll4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,807,049 - 7,817,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,807,049 - 7,816,346 (+)NCBIChiLan1.0ChiLan1.0
DLL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,171,696 - 30,182,800 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,323,041 - 34,334,142 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,871,584 - 19,881,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,121,238 - 38,130,950 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,121,574 - 38,129,471 (+)Ensemblpanpan1.1panPan2
Dll4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,472,876 - 86,482,195 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,320,933 - 4,330,253 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,320,235 - 4,330,251 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,376,721 - 130,386,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,376,720 - 130,386,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,539,044 - 145,548,860 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,056,473 - 42,066,283 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,056,331 - 42,065,828 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,919,102 - 98,929,217 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,179,731 - 8,191,284 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,179,729 - 8,189,001 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DLL4
80 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5 11 4 5 10 6
Low 3 11 6 2 6 6 6 7 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000014966   ⟹   ENSCAFP00000013852
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl308,059,661 - 8,067,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000070435   ⟹   ENSCAFP00000061164
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl308,060,065 - 8,067,940 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000077155   ⟹   ENSCAFP00000055652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl308,060,065 - 8,067,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092635   ⟹   ENSCAFP00000052849
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl308,059,512 - 8,067,548 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845051568   ⟹   ENSCAFP00845040461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl308,185,217 - 8,197,617 (+)Ensembl
RefSeq Acc Id: XM_038442008   ⟹   XP_038297936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0308,188,071 - 8,197,632 (+)NCBI
RefSeq Acc Id: XM_038442009   ⟹   XP_038297937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0308,188,070 - 8,197,632 (+)NCBI
RefSeq Acc Id: XM_038461536   ⟹   XP_038317464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha308,114,087 - 8,123,649 (+)NCBI
RefSeq Acc Id: XM_038516497   ⟹   XP_038372425
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1308,111,271 - 8,120,832 (+)NCBI
RefSeq Acc Id: XM_038516498   ⟹   XP_038372426
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1308,111,270 - 8,120,832 (+)NCBI
RefSeq Acc Id: XM_038580089   ⟹   XP_038436017
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,349,054 - 8,358,618 (+)NCBI
RefSeq Acc Id: XM_038580090   ⟹   XP_038436018
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0308,349,053 - 8,358,618 (+)NCBI
RefSeq Acc Id: XM_038644371   ⟹   XP_038500299
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0308,217,669 - 8,227,235 (+)NCBI
RefSeq Acc Id: XM_038644372   ⟹   XP_038500300
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0308,217,668 - 8,227,235 (+)NCBI
RefSeq Acc Id: XM_852991   ⟹   XP_858084
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1308,059,463 - 8,068,742 (+)NCBI
Dog10K_Boxer_Tasha308,114,088 - 8,123,649 (+)NCBI
Sequence:
RefSeq Acc Id: XP_858084   ⟸   XM_852991
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TVF9 (UniProtKB/TrEMBL),   A0A8C0JXE7 (UniProtKB/TrEMBL),   A0A8C0TZ79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000061164   ⟸   ENSCAFT00000070435
RefSeq Acc Id: ENSCAFP00000055652   ⟸   ENSCAFT00000077155
RefSeq Acc Id: ENSCAFP00000052849   ⟸   ENSCAFT00000092635
RefSeq Acc Id: ENSCAFP00000013852   ⟸   ENSCAFT00000014966
RefSeq Acc Id: XP_038372426   ⟸   XM_038516498
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038372425   ⟸   XM_038516497
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038500300   ⟸   XM_038644372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038500299   ⟸   XM_038644371
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038297937   ⟸   XM_038442009
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TVF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297936   ⟸   XM_038442008
- Peptide Label: isoform X1
- UniProtKB: A0A8C0TVF9 (UniProtKB/TrEMBL),   A0A8C0JXE7 (UniProtKB/TrEMBL),   A0A8C0TZ79 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038317464   ⟸   XM_038461536
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TVF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436018   ⟸   XM_038580090
- Peptide Label: isoform X2
- UniProtKB: A0A8C0TVF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038436017   ⟸   XM_038580089
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JXE7 (UniProtKB/TrEMBL),   A0A8C0TVF9 (UniProtKB/TrEMBL),   A0A8C0TZ79 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845040461   ⟸   ENSCAFT00845051568
Protein Domains
DSL   EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009401 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030023278 UniProtKB/TrEMBL
  ENSCAFG00040025725 UniProtKB/TrEMBL
  ENSCAFG00845029137 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014966.4 UniProtKB/TrEMBL
  ENSCAFT00030042786.1 UniProtKB/TrEMBL
  ENSCAFT00040048024.1 UniProtKB/TrEMBL
  ENSCAFT00040048025.1 UniProtKB/TrEMBL
  ENSCAFT00845051568 ENTREZGENE
  ENSCAFT00845051568.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.25.140 UniProtKB/TrEMBL
  2.60.40.3510 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro DSL UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch_ligand_N UniProtKB/TrEMBL
NCBI Gene DLL4 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1 UniProtKB/TrEMBL
Pfam DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  JAG1-like_EGF2 UniProtKB/TrEMBL
  MNNL UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  DSL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART DSL UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A8C0JXE7 ENTREZGENE
  A0A8C0TVF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TZ79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q0Q1_CANLF UniProtKB/TrEMBL
  A0A8P0SEF9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:39987 ENTREZGENE