| 708482 | Dhrs4 | dehydrogenase/reductase 4 | ENCODES a protein that exhibits 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); all-trans-retinol dehydrogenase (NADP+) activity (ortholog); INVOLVED IN alcohol metabolic process (ortholog); ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN peroxisome; mitochondrion (ortholog); nucleus (ortholog); INTERACTS WITH (+)-schisandrin B; 2,2',4,4'-Tetrabromodiphenyl ether; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | 15 | 32924482 | 32948103 | Rat | 154 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732149 | DHRS4 | dehydrogenase/reductase 4 | Enables identical protein binding activity; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in several processes, including ketone metabolic process; positive regu lation of reactive oxygen species metabolic process; and steroid metabolic process. Located in nucleus and peroxisomal membrane. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 23953770 | 23969279 | Human | 144 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 732150 | Dhrs4 | dehydrogenase/reductase 4 | Enables retinal dehydrogenase activity. Acts upstream of or within retinal metabolic process. Located in mitochondrion and peroxisome. Orthologous to several human genes including DHRS4 (dehydrogenase/reductase 4). [provided by Alliance of Genome Resources, Apr 2025] | 14 | 55715880 | 55727797 | Mouse | 144 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 12169889 | DHRS4 | hydrogenase/reductase 4 | ENCODES a protein that exhibits 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); all-trans-retinol dehydrogenase (NADP+) activity (ortholog); INVOLVED IN alcohol metabolic process (ortholog); ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN nucleus (ortholog); peroxisomal membrane (ortholog); peroxisome (ortholog); INTERACTS WITH 16-Ketoestrone; 3-oxo-5beta-cholanic acid; 9,10-phenanthroquinone | 8 | 4046532 | 4058498 | Dog | 60 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 11968550 | DHRS4 | dehydrogenase/reductase 4 | ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NADP+) activity (ortholog); retinal dehydrogenase (NAD+) activity (ortholog); INVOLVED IN retinal metabolic process (ortholog); retinoid metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency path way; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog); peroxisome (ortholog) | | | | Bonobo | 27 | symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14069178 | DHRS4 | dehydrogenase/reductase (SDR family) member 4 | ENCODES a protein that exhibits 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity; all-trans-retinol dehydrogenase (NADP+) activity; identical protein binding; INVOLVED IN ketone metabolic process; retinoid metabolic process; steroid metabolic process; PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN peroxisome; mitochondrion (ortholog); nucleus (ortholog) | | | | Pig | 33 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155251001 | dhrs4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155255779 | dhrs4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1351560 | DHRS4-AS1 | DHRS4 antisense RNA 1 | INTERACTS WITH 3-isobutyl-1-methyl-7H-xanthine; 4,4'-sulfonyldiphenol; 5-aza-2'-deoxycytidine | 14 | 23938731 | 23955112 | Human | 24 | symbol , COSMIC , name , Human Proteome Map , old_gene_symbol | gene, ncrna, VALIDATED [RefSeq] |
| 18912725 | LOC101708169 | dehydrogenase/reductase SDR family member 4 | ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NADP+) activity (inferred); carbonyl reductase (NADPH) activity (inferred); oxidoreductase activity (inferred); INVOLVED IN retinal metabolic process (inferred); retinol metabolic process (inferred); FOUND IN peroxisome (inferred) | | | | Naked Mole-Rat | 7 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12717622 | LOC101961668 | dehydrogenase/reductase SDR family member 2, mitochondrial | ENCODES a protein that exhibits all-trans-retinol dehydrogenase (NADP+) activity (inferred); carbonyl reductase (NADPH) activity (inferred); oxidoreductase activity (inferred); INVOLVED IN retinol metabolic process (inferred) | NW_004936722 | 760542 | 809409 | Squirrel | 5 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18755275 | LOC103231490 | dehydrogenase/reductase SDR family member 4 | ENCODES a protein that exhibits 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity (ortholog); alcohol dehydrogenase [NAD(P)+] activity (ortholog); all-trans-retinol dehydrogenase (NADP+) activity (ortholog); INVOLVED IN alcohol metabolic process (ortholog); ketone metabolic process (ortholog); positive regulation of reactive oxygen species metabolic process (ortholog); PARTICIPATES IN retinol metabolic pathway; vitamin A deficiency pathway; ASSOCIATED WITH COVID-19 (ortholog); FOUND IN mitochondrion (ortholog); nucleus (ortholog); peroxisomal membrane (ortholog) | | | | Green Monkey | 31 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16561902 | AL160237.2 | dehydrogenase/reductase (SDR family) member 4 (DHRS4) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 1352138 | DHRS4L1 | dehydrogenase/reductase 4 like 1 (pseudogene) | Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be involved in retinal metabolic process. Predicted to be active in peroxisome. [provided by Alliance of Genome Resources, Jul 2025] | 14 | 24007084 | 24051377 | Human | 14 | symbol , COSMIC , Human Proteome Map | gene, pseudo, VALIDATED [RefSeq] |
| 1353509 | DHRS4L2 | dehydrogenase/reductase 4 like 2 | This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010] | 14 | 23969874 | 24006408 | Human | 21 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 18666267 | LOC103228700 | dehydrogenase/reductase SDR family member 4 | FOUND IN mitochondrion (ortholog) | | | | Green Monkey | 1 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |