| 1308384 | Dclk2 | doublecortin-like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase activity (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskeleton (inferred); I NTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 2 | 174506660 | 174636353 | Rat | 110 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1348460 | DCLK2 | doublecortin like kinase 2 | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows s ubstantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010] | 4 | 150078445 | 150257438 | Human | 108 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1619992 | Dclk2 | doublecortin-like kinase 2 | This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows s ubstantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010] | 3 | 86693457 | 86828292 | Mouse | 123 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8925057 | Dclk2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase activity (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog) | NW_004955471 | 4903077 | 5044426 | Chinchilla | 10 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12008452 | DCLK2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskeleton (inferred) | 4 | 142412945 | 142590129 | Bonobo | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12145274 | DCLK2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskeleton (inferred) | 15 | 48119227 | 48365807 | Dog | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12597178 | Dclk2 | doublecortin like kinase 2 | ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); microtubule binding (inferred); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskelet on (inferred) | NW_004936689 | 272136 | 428145 | Squirrel | 26 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155246189 | dclk2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625885968 | Dclk2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase activity (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog) | | | | Black Rat | 10 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18682287 | DCLK2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskeleton (inferred) | | | | Green Monkey | 23 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14019289 | DCLK2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN cytoskeleton (inferred) | | | | Pig | 29 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18930959 | Dclk2 | doublecortin like kinase 2 | ENCODES a protein that exhibits microtubule binding (ortholog); INVOLVED IN hippocampus development (ortholog); microtubule cytoskeleton organization (ortholog); negative regulation of protein localization to nucleus (ortholog); FOUND IN axoneme (inferred); cell projection (inferred); cytoplasm (inf erred) | | | | Naked Mole-Rat | 32 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 405856998 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626469142 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856471 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862211 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626468494 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865178 | dclk2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239082 | dclk2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1618935 | Dclk3 | doublecortin-like kinase 3 | This gene encodes a member of the protein kinase superfamily and the doublecortin family. Differently from the other two closely related family members (DCLK1 and DCLK2), the protein encoded by this gene contains only one N-terminal doublecortin domain and is un able to bind microtubules and to regulate microtubule polymerization. The protein contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. [provided by RefSeq, Sep 2010] | 9 | 111268149 | 111318679 | Mouse | 97 | description | gene, protein-coding, REVIEWED [RefSeq] |
