| 1308286 | Dars2 | aspartyl-tRNA synthetase 2 (mitochondrial) | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); PARTICIPATES IN aminoacyl-tRN A biosynthetic pathway; ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH (+)-schisandrin B; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene | 13 | 75842078 | 75870319 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1550719 | Dars2 | aspartyl-tRNA synthetase 2 (mitochondrial) | Predicted to enable aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; and protein homodimerization activity. Predicted to be involved in aspartyl-tRNA aminoacylation and mitochondrial asparaginyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in several structures, in cluding alimentary system; genitourinary system; integumental system; midbrain; and telencephalon. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 160868171 | 160898236 | Mouse | 130 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1605663 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL ). [provided by RefSeq, Nov 2009] | 1 | 173824673 | 173858546 | Human | 238 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8868683 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | NW_004955406 | 13964087 | 13991691 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11711456 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | 1 | 149342301 | 149375979 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12115466 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN lysyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); AS SOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | 7 | 25378705 | 25406975 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12618348 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | NW_004936481 | 14029478 | 14052724 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258161 | dars2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14029055 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrion (ortholog) | | | | Pig | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18636421 | DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625850590 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aspartate-tRNA ligase activity (ortholog); aspartate-tRNA(Asn) ligase activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN mitochondrial asparaginyl-tRNA aminoacylation (ortholog); tRNA aminoacylation (ortholog); ASSOCIATED WITH cerebellar at axia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN mitochondrial matrix (ortholog); mitochondrial membrane (ortholog); mitochondrion (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918314 | Dars2 | aspartyl-tRNA synthetase 2, mitochondrial | ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); aspartate-tRNA ligase activity (inferred); aspartate-tRNA(Asn) ligase activity (inferred); INVOLVED IN aspartyl-tRNA aminoacylation (inferred); mitochondrial asparaginyl-tRNA aminoacylation (inferred); translation (inferred); ASSOCIATED WITH cerebellar ataxia (ortholog); clubfoot (ortholog); Gait Ataxia (ortholog); FOUND IN cytoplasm (inferred); mitochondrial matrix (inferred); mitochondrial membrane (inferred) | | | | Naked Mole-Rat | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238936 | dars2.L | | | | | | African Clawed Frog | | symbol | gene, null |