| 1342724 | DAND5 | DAN domain BMP antagonist family member 5 | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystin e knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008] | 19 | 12969576 | 12974760 | Human | 68 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1590249 | Dand5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog); INTERACTS WITH bisphenol A; copper atom; copper(0) | 19 | 40231061 | 40245329 | Rat | 41 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1620875 | Dand5 | DAN domain family member 5, BMP antagonist | Enables morphogen activity. Involved in determination of left/right asymmetry in lateral mesoderm; heart development; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within determination of left/right symmetry and negative regu lation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; gut; node; and primitive streak. Human ortholog(s) of this gene implicated in visceral heterotaxy 13. Orthologous to human DAND5 (DAN domain BMP antagonist family member 5). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 85542034 | 85558894 | Mouse | 62 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8814457 | Dand5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog) | NW_004955415 | 32012637 | 32015965 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12077049 | DAND5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (inferred); nodal binding (inferred); protein sequestering activity (inferred); INVOLVED IN determination of left/right symmetry (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral heterotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog); FOUND IN extracellular region (inferred) | 20 | 49225351 | 49228940 | Dog | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12538674 | Dand5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (inferred); nodal binding (inferred); protein sequestering activity (inferred); INVOLVED IN determination of left/right symmetry (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral heterotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog); FOUND IN extracellular region (inferred) | NW_004936659 | 2022657 | 2025353 | Squirrel | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 32731554 | DAND5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog) | 19 | 12529830 | 12536052 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625847787 | Dand5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog) | | | | Black Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247946 | dand5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13982615 | DAND5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog) | | | | Pig | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913962 | Dand5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (ortholog); INVOLVED IN atrial septum development (ortholog); determination of heart left/right asymmetry (ortholog); determination of left/right asymmetry in lateral mesoderm (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral hete rotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog); FOUND IN extracellular region (inferred) | | | | Naked Mole-Rat | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18750030 | DAND5 | DAN domain BMP antagonist family member 5 | ENCODES a protein that exhibits morphogen activity (inferred); nodal binding (inferred); protein sequestering activity (inferred); INVOLVED IN determination of left/right symmetry (ortholog); negative regulation of transforming growth factor beta receptor signaling pathway (ortholog); regulation of transforming growth factor beta receptor signaling pathway (ortholog); ASSOCIATED WITH visceral heterotaxy (ortholog); visceral heterotaxy 13 (ortholog); visceral heterotaxy 5 (ortholog); FOUND IN extracellular region (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249845 | dand5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251890 | dand5.S | | | | | | African Clawed Frog | | symbol | gene, null |
