| 620601 | Ackr3 | atypical chemokine receptor 3 | ENCODES a protein that exhibits C-X-C chemokine binding (ortholog); C-X-C chemokine receptor activity (ortholog); scavenger receptor activity (ortholog); INVOLVED IN positive regulation of mesenchymal stem cell migration; chemokine-mediated signaling pathway (ortholog); negative regulation of cell p opulation proliferation (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; ASSOCIATED WITH carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); endosome (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 9 | 98247300 | 98258877 | Rat | 280 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734310 | Ackr3 | atypical chemokine receptor 3 | Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in oculomotor nerve development. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be lo cated in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical chemokine receptor 3). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 90131702 | 90143446 | Mouse | 340 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1343702 | ACKR3 | atypical chemokine receptor 3 | This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a corecep tor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008] | 2 | 236537122 | 236582354 | Human | 268 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 11971495 | ACKR3 | atypical chemokine receptor 3 | ENCODES a protein that exhibits C-X-C chemokine binding (inferred); C-X-C chemokine receptor activity (inferred); chemokine binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); positive regulation of mesenchymal stem cell migration (ortholog); ASSOCIATED WITH carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (inferred); clathrin-coated pit (inferred); endosome (inferred) | 2B | 123795664 | 123810067 | Bonobo | 44 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12051505 | ACKR3 | atypical chemokine receptor 3 | ENCODES a protein that exhibits C-X-C chemokine binding (ortholog); scavenger receptor activity (ortholog); INVOLVED IN negative regulation of cell population proliferation (ortholog); oculomotor nerve development (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); ASSOCIATED WITH c arcinoma (ortholog); clear cell renal cell carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (ortholog); clathrin-coated pit (ortholog); endosome (ortholog) | 25 | 47327921 | 47339632 | Dog | 63 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18932355 | Ackr3 | atypical chemokine receptor 3 | ENCODES a protein that exhibits C-X-C chemokine binding (inferred); C-X-C chemokine receptor activity (inferred); chemokine binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); positive regulation of mesenchymal stem cell migration (ortholog); ASSOCIATED WITH carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (inferred); clathrin-coated pit (inferred); endosome (inferred) | | | | Naked Mole-Rat | 44 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 14053692 | ACKR3 | atypical chemokine receptor 3 | ENCODES a protein that exhibits C-X-C chemokine binding (inferred); C-X-C chemokine receptor activity (inferred); chemokine binding (inferred); INVOLVED IN negative regulation of cell population proliferation (ortholog); positive regulation of ERK1 and ERK2 cascade (ortholog); positive regulation of mesenchymal stem cell migration (ortholog); ASSOCIATED WITH carcinoma (ortholog); clear cell renal cell carcinoma (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (inferred); clathrin-coated pit (inferred); endosome (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 52 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1352090 | CXCR6 | C-X-C motif chemokine receptor 6 | The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the CXC chemokine receptor family. This family also includes CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, and CXCR7. This gene, which maps to the chemokine re ceptor gene cluster, is expressed in several T lymphocyte subsets and bone marrow stromal cells. The encoded protein and its exclusive ligand, chemokine ligand 16 (CCL16), are part of a signalling pathway that regulates T lymphocyte migration to various peripheral tissues (the liver, spleen red pulp, intestine, lungs, and skin) and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. CXCR6/CCL16 also controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are an important first line of defense against respiratory pathogens. The encoded protein serves as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4. [provided by RefSeq, Aug 2020] | 3 | 45940915 | 45948351 | Human | 79 | description | gene, protein-coding, REVIEWED [RefSeq] |
