| 1307681 | Ctsg | cathepsin G | ENCODES a protein that exhibits caspase binding (ortholog); heparin binding (ortholog); peptidase activity (ortholog); INVOLVED IN biofilm matrix disassembly (ortholog); defense response to fungus (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN Entamoebiasis pathw ay; renin-angiotensin cascade pathway; systemic lupus erythematosus pathway; ASSOCIATED WITH Reperfusion Injury (ortholog); FOUND IN cytoplasmic stress granule (ortholog); cytosol (ortholog); extracellular space (ortholog); INTERACTS WITH anilines; bisphenol A; bortezomib | 15 | 33901230 | 33907596 | Rat | 150 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317010 | CTSG | cathepsin G | The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens , and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014] | 14 | 24573518 | 24576250 | Human | 126 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317011 | Ctsg | cathepsin G | This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous k nockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015] | 14 | 56337342 | 56340031 | Mouse | 177 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 11935451 | CTSG | cathepsin G | ENCODES a protein that exhibits caspase binding (inferred); heparin binding (inferred); hydrolase activity (inferred); INVOLVED IN defense response to fungus (ortholog); defense response to Gram-positive bacterium (ortholog); neutrophil-mediated killing of gram-positive bacterium (ortholog); ASSOCIA TED WITH Reperfusion Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); cytosol (inferred) | 14 | 5342517 | 5345218 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12199795 | CTSG | cathepsin G | ENCODES a protein that exhibits caspase binding (inferred); heparin binding (inferred); hydrolase activity (inferred); INVOLVED IN defense response to fungus (ortholog); defense response to Gram-positive bacterium (ortholog); neutrophil-mediated killing of gram-positive bacterium (ortholog); ASSOCIA TED WITH Reperfusion Injury (ortholog); FOUND IN cytoplasmic stress granule (inferred); cytosol (inferred); extracellular space (inferred) | 8 | 4483327 | 4485933 | Dog | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18537332 | CTSG | cathepsin G | ENCODES a protein that exhibits caspase binding (inferred); heparin binding (inferred); hydrolase activity (inferred); INVOLVED IN defense response to fungus (ortholog); defense response to Gram-positive bacterium (ortholog); neutrophil-mediated killing of gram-positive bacterium (ortholog); ASSOCIA TED WITH Reperfusion Injury (ortholog); FOUND IN cytoplasm (inferred); cytoplasmic stress granule (inferred); cytosol (inferred) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284134316 | ctsg | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14058348 | LOC100154047 | cathepsin G | ENCODES a protein that exhibits caspase binding (ortholog); heparin binding (ortholog); receptor ligand activity (ortholog); INVOLVED IN biofilm matrix disassembly (ortholog); defense response to fungus (ortholog); defense response to Gram-negative bacterium (ortholog); ASSOCIATED WITH Reperfusion I njury (ortholog); FOUND IN cytoplasmic stress granule (ortholog); cytosol (ortholog); extracellular space (ortholog) | | | | Pig | 42 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8732528 | LOC102023670 | cathepsin G | | NW_004955409 | 35767304 | 35770140 | Chinchilla | | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1353495 | GZMB | granzyme B | This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces ta rget cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016] | 14 | 24630954 | 24634190 | Human | 197 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1348061 | GZMH | granzyme H | This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constituti vely expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015] | 14 | 24606480 | 24609685 | Human | 38 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
