| 1309603 | Csta | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (ortholog); protease binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); keratinocyte differentiation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH Disease Progression (ortholog); e osinophilic chronic rhinosinusitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); extracellular space (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; ammonium chloride | 11 | 78125813 | 78136818 | Rat | 146 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1320029 | CSTA | cystatin A | The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the t ype 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008] | 3 | 122325248 | 122341969 | Human | 178 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9015132 | Csta | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (ortholog); protease binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); keratinocyte differentiation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH Disease Progression (ortholog); e osinophilic chronic rhinosinusitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (ortholog); cytoplasm (ortholog); extracellular space (ortholog) | NW_004955427 | 21617099 | 21630712 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11699319 | CSTA | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); INVOLVED IN peptide cross-linking (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosin usitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferred); cytosol (inferred) | 3 | 119417489 | 119432244 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12413869 | CSTA | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); INVOLVED IN peptide cross-linking (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosin usitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferred); extracellular space (inferred) | 33 | 25477789 | 25489123 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12529501 | Csta | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); INVOLVED IN peptide cross-linking (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosin usitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936536 | 8649890 | 8662472 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18740822 | CSTA | cystatin A | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); INVOLVED IN peptide cross-linking (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosin usitis (ortholog); genetic disease (ortholog); FOUND IN cornified envelope (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18925413 | Csta | cystatin A | ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); keratinocyte differentiation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosinusitis (ortholog); genetic dise ase (ortholog); FOUND IN cornified envelope (ortholog); extracellular space (ortholog); peptidase inhibitor complex (ortholog) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1614211 | Csta1 | cystatin A1 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 35940316 | 35951559 | Mouse | 16 | symbol , PhenoGen , description , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1307831 | Stfa3 | stefin A3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); FOUND IN cornified envelope; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide | 11 | 77859070 | 77864212 | Rat | 19 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1322022 | Csta2 | cystatin A family member 2 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36041932 | 36077813 | Mouse | 153 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1594822 | Csta3 | cystatin A family member 3 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); FOUND IN cytoplasm (inferred); INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether (ortholog); lipopolysaccharide (ortholog); phenylarsine oxide (ortholog) | 11 | 77879550 | 77886954 | Rat | 8 | symbol , PhenoGen | gene, protein-coding, MODEL [RefSeq] |
| 1613950 | Csta3 | cystatin A family member 3 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36030773 | 36038158 | Mouse | 22 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1619080 | Cstad | CSA-conditional, T cell activation-dependent protein | Acts upstream of or within mitochondrial membrane organization. Located in mitochondrial outer membrane. Is expressed in cranium. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 30485056 | 30498957 | Mouse | 18 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 14226132 | LOC396866 | stefin A1 | ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity (inferred); endopeptidase inhibitor activity (inferred); peptidase inhibitor activity (inferred); FOUND IN cytoplasm (inferred) | | | | Pig | 7 | ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14248033 | LOC396867 | stefin A8 | ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN cell-cell adhesion (ortholog); keratinocyte differentiation (ortholog); negative regulation of proteolysis (ortholog); ASSOCIATED WITH Disease Progression (ortholog); eosinophilic chronic rhinosinusitis (ortholog); genetic dise ase (ortholog); FOUND IN cornified envelope (ortholog); extracellular space (ortholog); peptidase inhibitor complex (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 27 | ensembl_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1621936 | Gm1330 | predicted gene 1330 | Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 148838717 | 148841256 | Mouse | 4 | old_gene_symbol | gene, ncrna, MODEL [RefSeq] |
| 1613956 | Gm14129 | predicted gene 14129 | | | | | Mouse | | old_gene_symbol | gene, protein-coding |
| 1623837 | Cstdc3 | cystatin domain containing 3 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36125719 | 36133079 | Mouse | 3 | description | gene, protein-coding, MODEL [RefSeq] |
| 1622672 | Cstdc4 | cystatin domain containing 4 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36004582 | 36008481 | Mouse | 26 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1616013 | Cstdc5 | cystatin domain containing 5 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36179744 | 36187932 | Mouse | 23 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1616014 | Cstdc6 | cystatin domain containing 6 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36142027 | 36154694 | Mouse | 20 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1316835 | Stfa1 | stefin A1 | Enables endopeptidase inhibitor activity. Acts upstream of or within negative regulation of endopeptidase activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by A lliance of Genome Resources, Jul 2025] | 16 | 36097510 | 36105733 | Mouse | 38 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1321411 | Stfa2 | stefin A2 | Enables endopeptidase inhibitor activity. Acts upstream of or within negative regulation of endopeptidase activity. Predicted to be located in several cellular components, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predict ed to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 36224308 | 36228725 | Mouse | 36 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1615590 | Stfa2l1 | stefin A2 like 1 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 35977181 | 35982318 | Mouse | 46 | description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317255 | Stfa3 | stefin A3 | Predicted to enable cysteine-type endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in several processes, including keratinocyte differentiation; negative regulation of peptidase activity; and peptide cross-linking. Predicted to be located in several cellular c omponents, including cornified envelope; extracellular space; and nucleoplasm. Predicted to be part of peptidase inhibitor complex. Predicted to be active in cytosol. Is expressed in femur; humerus; radius; tibia; and ulna. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A). [provided by Alliance of Genome Resources, Apr 2025] | 16 | 36270899 | 36275754 | Mouse | 38 | description | gene, protein-coding, PROVISIONAL [RefSeq] |