| 631427 | Cryl1 | crystallin, lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (ortholog); NAD+ binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (ortholog); PARTICIPATES IN pentose and glucuronate interconversion pathway; AS SOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene | 15 | 35542628 | 35661563 | Rat | 162 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735568 | CRYL1 | crystallin lambda 1 | The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme requires NAD(H) as a coenzyme, and is inhibited by inorganic phosphate. A similar gene in the rabbit is thought to serve a structural role in the lens of the eye. [provided by RefSeq, Jul 2008] | 13 | 20403669 | 20525857 | Human | 161 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735569 | Cryl1 | crystallin, lambda 1 | Predicted to enable L-gulonate 3-dehydrogenase activity; NAD+ binding activity; and protein homodimerization activity. Involved in D-glucuronate catabolic process to D-xylulose 5-phosphate. Is active in cytosol. Is expressed in several structures, including alimentary system; hemolymphoid system; me tanephros; nose; and secondary oocyte. Orthologous to human CRYL1 (crystallin lambda 1). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 57512491 | 57635940 | Mouse | 165 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 9063771 | Cryl1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (ortholog); NAD+ binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (ortholog); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortho log); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytosol (ortholog) | NW_004955497 | 1183707 | 1316720 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11675739 | CRYL1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (inferred); NAD+ binding (inferred); oxidoreductase activity (inferred); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 13 | 1729724 | 1852031 | Bonobo | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12076101 | CRYL1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (inferred); NAD+ binding (inferred); oxidoreductase activity (inferred); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 25 | 17551586 | 17733754 | Dog | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12710219 | Cryl1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (inferred); NAD+ binding (inferred); oxidoreductase activity (inferred); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936720 | 1201725 | 1334483 | Squirrel | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18736700 | CRYL1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (inferred); NAD+ binding (inferred); oxidoreductase activity (inferred); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13972686 | CRYL1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (ortholog); NAD+ binding (ortholog); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 21 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626022731 | Cryl1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (ortholog); NAD+ binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (ortholog); ASSOCIATED WITH perinatal necrotizing enterocolitis (ortholog); Pro static Neoplasms (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 7 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238257 | cryl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18908496 | Cryl1 | crystallin lambda 1 | ENCODES a protein that exhibits L-gulonate 3-dehydrogenase activity (inferred); NAD+ binding (inferred); oxidoreductase activity (inferred); INVOLVED IN D-glucuronate catabolic process to D-xylulose 5-phosphate (inferred); fatty acid metabolic process (inferred); ASSOCIATED WITH autosomal recessive nonsyndromic deafness 1A (ortholog); perinatal necrotizing enterocolitis (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239053 | cryl1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155238258 | cryl1.S | | | | | | African Clawed Frog | | symbol | gene, null |