| 70931 | Cpn1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity; INVOLVED IN bradykinin catabolic process; protein catabolic process; response to glucocorticoid; PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ortholog); FOUND IN extracellular space; INTERA CTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole | 1 | 252793786 | 252822675 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734334 | CPN1 | carboxypeptidase N subunit 1 | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tet ramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008] | 10 | 100042193 | 100081869 | Human | 130 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734335 | Cpn1 | carboxypeptidase N, polypeptide 1 | Enables carboxypeptidase activity. Predicted to be involved in several processes, including bradykinin catabolic process; protein processing; and response to glucocorticoid. Predicted to be active in extracellular space. Is expressed in several structures, including gonad; gut; liver; neural tube; a nd yolk sac. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency. Orthologous to human CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Apr 2025] | 19 | 43944746 | 43974990 | Mouse | 131 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8701837 | Cpn1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | NW_004955507 | 5926508 | 5952515 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11938792 | CPN1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | 10 | 96647273 | 96689346 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12353279 | CPN1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | 28 | 12875737 | 12902514 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12471942 | Cpn1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | NW_004936636 | 145148 | 172865 | Squirrel | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14016043 | CPN1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18767587 | CPN1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902127 | Cpn1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866151 | CPN1 | carboxypeptidase N subunit 1 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155247231 | cpn1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626155841 | Cpn1 | carboxypeptidase N subunit 1 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN bradykinin catabolic process (ortholog); protein catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN kallikrein-kinin cascade pathway; ASSOCIATED WITH carboxypeptidase N deficiency (ort holog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155246538 | cpn1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251059 | cpn1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1322452 | CPNE1 | copine 1 | Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the enc oded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008] | 20 | 35626044 | 35664900 | Human | 121 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 10428 | Cyp11b1 | cytochrome P450, family 11, subfamily b, polypeptide 1 | Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several disea ses, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B1 (cytochrome P450 family 11 subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 74706741 | 74713492 | Mouse | 113 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 70835 | CYP11B1 | cytochrome P450 family 11 subfamily B member 1 | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008] | 8 | 142872357 | 142879825 | Human | 521 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2844 | Hspe1 | heat shock protein family E (Hsp10) member 1 | ENCODES a protein that exhibits protein-folding chaperone binding (ortholog); INVOLVED IN protein folding (inferred); ASSOCIATED WITH cardiomyopathy (ortholog); FOUND IN mitochondrial matrix; mitochondrial inner membrane (ortholog); mitochondrion (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlor ophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol | 9 | 64084327 | 64087415 | Rat | 243 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10743 | Hspe1 | heat shock protein 1 (chaperonin 10) | Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Located in mitochondrion. Is expressed in brain; brainstem nucleus; early conceptus; and midb rain ventricular layer. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 55127307 | 55130476 | Mouse | 246 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 733544 | HSPE1 | heat shock protein family E (Hsp10) member 1 | This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-cha peronin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011] | 2 | 197500379 | 197503449 | Human | 253 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 2299497 | Hspe1-ps1 | heat shock protein 1 (chaperonin 10), pseudogene 1 | | 12 | 68137102 | 68137957 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623066 | Hspe1-ps2 | heat shock protein 1 (chaperonin 10), pseudogene 2 | INTERACTS WITH pirinixic acid; triptonide | 12 | 81446582 | 81447017 | Mouse | 2 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623065 | Hspe1-ps3 | heat shock protein 1 (chaperonin 10), pseudogene 3 | | 5 | 25596565 | 25597003 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623064 | Hspe1-ps4 | heat shock protein 1 (chaperonin 10), pseudogene 4 | | 4 | 138877580 | 138877625 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623063 | Hspe1-ps5 | heat shock protein 1 (chaperonin 10), pseudogene 5 | | 2 | 72786165 | 72786706 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1623062 | Hspe1-ps6 | heat shock protein 1 (chaperonin 10), pseudogene 6 | | 4 | 95960546 | 95960944 | Mouse | | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1619514 | Hspe1-rs1 | heat shock protein 1 (chaperonin 10), related sequence 1 | Enables growth factor activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to act upstream of or within female pregnancy. Located in mitochondrion. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Re sources, Apr 2025] | 18 | 47245206 | 47245741 | Mouse | 17 | old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1561150 | Hspd1l2 | heat shock protein family D (Hsp60) member 1 like 2 | ENCODES a protein that exhibits ATP binding (inferred); protein folding chaperone (inferred); INVOLVED IN protein folding (inferred); FOUND IN mitochondrion (inferred); INTERACTS WITH bisphenol A; C60 fullerene; Cuprizon | 5 | 112247410 | 112247718 | Rat | 14 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
