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Gene: Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1) Mus musculus
Analyze
Symbol:
Cyp11b1
Name:
cytochrome P450, family 11, subfamily b, polypeptide 1
RGD ID:
10428
MGI Page
MGI
Description:
Enables corticosterone 18-monooxygenase activity. Acts upstream of or within glucocorticoid biosynthetic process. Located in mitochondrion. Is expressed in adrenal gland; gland; lung; and testis. Used to study congenital adrenal hyperplasia. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2).
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
AA389061; CPN1; Cyp11; Cyp11b; Cyp11b-; Cyp11b-1; FHI; steroid-11-beta-hydroxylase
RGD Orthologs
Alliance Genes
No known orthologs.
More Info
homologs ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Other homologs 2
Homo sapiens (human):
CYP11B1 (cytochrome P450 family 11 subfamily B member 1) HGNC
HGNC, Inparanoid, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Homo sapiens (human):
CYP11B2 (cytochrome P450 family 11 subfamily B member 2) HGNC
HGNC, HomoloGene, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cyp11b1 (cytochrome P450, family 11, subfamily b, polypeptide 1)
Alliance
DIOPT (Ensembl Compara|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Homo sapiens (human):
CYP11B1 (cytochrome P450 family 11 subfamily B member 1)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Homo sapiens (human):
CYP11B2 (cytochrome P450 family 11 subfamily B member 2)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
cyp11c1 (cytochrome P450, family 11, subfamily C, polypeptide 1)
Alliance
DIOPT (Ensembl Compara|Hieranoid|OMA|OrthoFinder|PANTHER|PhylomeDB)
Latest Assembly:
GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 15 74,706,741 - 74,713,492 (-) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 15 74,705,974 - 74,713,492 (-) Ensembl GRCm39 Ensembl GRCm38 15 74,834,892 - 74,841,643 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 15 74,834,125 - 74,841,643 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 15 74,665,322 - 74,672,073 (-) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 15 74,662,150 - 74,668,874 (-) NCBI MGSCv36 mm8 Celera 15 76,341,146 - 76,348,165 (-) NCBI Celera Cytogenetic Map 15 D3 NCBI cM Map 15 34.29 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - MGI
Only show annotations with direct experimental evidence (0 objects hidden)
2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene multiple interactions EXP 6480464 2 more ... CTD PMID:18651133 3,5,6-trichloro-2-pyridinol multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 3,5,6-trichloropyridine-2-one multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 3-phenoxybenzoic acid multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 4-nitrophenol increases expression EXP 6480464 4-nitrophenol results in increased expression of CYP11B1 mRNA CTD PMID:34673133 8-Br-cAMP multiple interactions EXP 6480464 [NR5A1 protein co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of CYP11B1 mRNA CTD PMID:21610156 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CYP11B1 mRNA CTD PMID:36189433 bisphenol A multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 Butylbenzyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 colforsin daropate hydrochloride multiple interactions EXP 6480464 1-chloro-4-(2 more ... CTD PMID:18651133 colforsin daropate hydrochloride increases activity EXP 6480464 Colforsin results in increased activity of CYP11B1 protein CTD PMID:18651133 DDE multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 dibutyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 diethyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 Diisodecyl phthalate multiple interactions EXP 6480464 [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate co-treated with bis(2-propylheptyl)phthalate co-treated with bisphenol A co-treated with 3 more ... CTD PMID:32518293 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of CYP11B1 mRNA CTD PMID:29524503 etomidate multiple interactions EXP 6480464 Etomidate inhibits the reaction [Colforsin results in increased activity of CYP11B1 protein] CTD PMID:18651133 etomidate decreases activity EXP 6480464 Etomidate results in decreased activity of CYP11B1 protein CTD PMID:18651133 mono(2-ethylhexyl) phthalate decreases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of CYP11B1 mRNA CTD PMID:36189433 PCB138 multiple interactions EXP 6480464 [2 more ... CTD PMID:25510870 perfluorohexanesulfonic acid increases expression EXP 6480464 perfluorohexanesulfonic acid results in increased expression of CYP11B1 mRNA CTD PMID:37995155 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CYP11B1 mRNA CTD PMID:37682722 tetrachloroethene decreases expression EXP 6480464 Tetrachloroethylene results in decreased expression of CYP11B1 mRNA CTD PMID:28973375
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
2,2',4,4',5,5'-hexachlorobiphenyl (EXP) 2,2',5,5'-tetrachlorobiphenyl (EXP) 2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene (EXP) 3,5,6-trichloro-2-pyridinol (EXP) 3,5,6-trichloropyridine-2-one (EXP) 3-phenoxybenzoic acid (EXP) 4-nitrophenol (EXP) 8-Br-cAMP (EXP)
References
References - curated
#
Reference Title
Reference Citation
1.
Fetal adrenal gland alterations in a rat model of adverse intrauterine environment.
Bibeau K, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Apr;298(4):R899-911. Epub 2009 Nov 18.
2.
Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.
Fallo F, etal., Eur J Endocrinol. 2002 Dec;147(6):795-802.
3.
Aldosterone synthesis in the brain contributes to Dahl salt-sensitive rat hypertension.
Gomez-Sanchez EP, etal., Exp Physiol. 2010 Jan;95(1):120-30. Epub 2009 Oct 16.
4.
Frame shift by insertion of 2 basepairs in codon 394 of CYP11B1 causes congenital adrenal hyperplasia due to steroid 11 beta-hydroxylase deficiency.
Helmberg A, etal., J Clin Endocrinol Metab 1992 Nov;75(5):1278-81.
5.
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension.
Lifton RP, etal., Nature. 1992 Jan 16;355(6357):262-5.
6.
Electronic Transfer of Homolog Data
MGD and Homologene mouse data transfer
7.
MGDs mouse GO annotations
MGD data from the GO Consortium
8.
Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.
Ohtani T, etal., J Hypertens. 2009 May;27(5):1074-83.
9.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
10.
Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.
Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
11.
KEGG Annotation Import Pipeline
Pipeline to import KEGG annotations from KEGG into RGD
12.
SMPDB Annotation Import Pipeline
Pipeline to import SMPDB annotations from SMPDB into RGD
13.
Genetic variation in aldosterone synthase predicts plasma glucose levels.
Ranade K, etal., Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13219-24. Epub 2001 Oct 30.
14.
Mouse MP Annotation Import Pipeline
RGD automated import pipeline
15.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
17.
Single strand conformation polymorphism (SSCP) analysis for the detection of mutations in the CYP11B1 gene.
Skinner CA, etal., J Clin Endocrinol Metab. 1996 Jun;81(6):2389-93.
18.
An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy.
Tiago AD, etal., Cardiovasc Res. 2002 Jun;54(3):584-9.
Additional References at PubMed
Genomics
QTLs in Region (GRCm39)
4141952 W3q7_m weight 3 weeks QTL 7 (mouse) Not determined 3489694 78601286 Mouse 4142252 Tailaq4_m tail length adjusted QTL 4 (mouse) Not determined 3489694 78601286 Mouse 4142448 Tailq6_m tail length QTL 6 (mouse) Not determined 3489694 78601286 Mouse 1357559 Scfq2_m subcutaneous fat pad weight QTL 2 (mouse) Not determined 15 3489694 78601286 Mouse 1357659 Epfpq4_m epididymal fat percentage QTL 4 (mouse) Not determined 15 3489694 78601286 Mouse 27226786 Feml11_m femur length 11, 5 week (mouse) 15 6129481 75871849 Mouse 27095932 Ulnl11_m ulna length 11, 16 week (mouse) 15 6129481 76384200 Mouse 27226717 Tibw4_m tibia width 4, proximal, 10 week (mouse) 15 6129481 78684200 Mouse 27226734 Tibmd5_m tibia midshaft diameter 5, 10 week (mouse) 15 6129481 86684201 Mouse 26884442 Sklq6_m skull length QTL 6, 5 week (mouse) 15 6129481 100797881 Mouse 27226721 Tibw8_m tibia width 8, proximal, 16 week (mouse) 15 6929481 75871849 Mouse 27226773 Tibl16_m tibia length 16, 10 week (mouse) 15 6929481 75871849 Mouse 27226777 Tibl8_m tibia length 8, 5 week (mouse) 15 6929481 84584201 Mouse 1301433 Rapop5_m radiation-induced apoptosis 5 (mouse) Not determined 15 9273022 79474762 Mouse 1357526 Hyplip2_m hyperlipidemia 2 (mouse) Not determined 15 12402203 102896555 Mouse 26884425 Cvht2_m cranial vault height 2, 5 week (mouse) 15 28800146 102008435 Mouse 26884392 Humsd8_m humerus midshaft diameter 8, 16 week (mouse) 15 29300146 76084200 Mouse 1558985 Eae32_m experimental allergic encephalomyelitis susceptibility 32 (mouse) Not determined 15 32578416 103425899 Mouse 27226729 Tibmd2_m tibia midshaft diameter 2, 5 week (mouse) 15 38000244 86684201 Mouse 26884402 Cvht9_m cranial vault height 9, 16 week (mouse) 15 42163396 95497881 Mouse 1357703 Vtbt17_m vertebral trabecular bone trait 17 (mouse) Not determined 15 44553313 78553437 Mouse 1301568 Tria2_m T-cell receptor induced activation 2 (mouse) Not determined 15 44859141 78859281 Mouse 1357756 Alaa4_m alopecia areata 4 (mouse) Not determined 15 46389646 80389845 Mouse 10755515 Amzn3_m anatomical modifier of Zfp423 3 (mouse) 15 46389646 80389845 Mouse 1301006 Hfib1_m hepatic fibrogenesis 1 (mouse) Not determined 15 47306334 81306479 Mouse 1301860 Gct3_m granulosa cell tumorigenesis 3 (mouse) Not determined 15 47409596 81409691 Mouse 26884397 Humsd5_m humerus midshaft diameter 5, 10 week (mouse) 15 48363396 98397881 Mouse 26884399 Humsd1_m humerus midshaft diameter 1, 5 week (mouse) 15 48363396 101708435 Mouse 1301429 Pcir3_m periosteal circumference 3 (mouse) Not determined 15 48465362 82465496 Mouse 1301779 Dpml_m dopamine loss (mouse) Not determined 15 51004694 76794493 Mouse 4142198 Hbtq_m habituation QTL (mouse) Not determined 15 51160708 85160833 Mouse 10045637 Heal27_m wound healing/regeneration 29 (mouse) Not determined 15 51418361 85418511 Mouse 10412067 Pain2_m pain 2 (mouse) Not determined 15 51645339 85645626 Mouse 1302080 Szs13_m seizure susceptibility 13 (mouse) Not determined 15 51685832 85694449 Mouse 1301708 Cocrb14_m cocaine related behavior 14 (mouse) Not determined 15 51806515 85806651 Mouse 38501067 Tip3_m tuberculosis immunophenotype 3, IFN-g level (mouse) 15 53563396 89584203 Mouse 13504731 Cath5_m carotid atherosclerosis 5 (mouse) 15 54789129 88789129 Mouse 1302074 Bmd4_m bone mineral density 4 (mouse) Not determined 15 56186708 103425899 Mouse 27095936 Ulnl4_m ulna length 4, 5 week (mouse) 15 56763396 87684201 Mouse 1300800 Ses3_m salmonella enteritidis susceptibility 3 (mouse) Not determined 15 57117005 91117153 Mouse 1357407 Pfat4_m predicted fat percentage 4 (mouse) 8.6 Body fat amount predicted fat percentage 15 57117005 91117153 Mouse 12880420 V25Dq8_m vitamin D inactive form serum level QTL 8 (mouse) 15 61584200 95584200 Mouse 1301601 Faq9_m fluctuating asymmetry QTL 9 (mouse) Not determined 15 63163903 97163995 Mouse 1558786 Msq1_m MAV-1 susceptibility QTL 1 (mouse) Not determined 15 63389646 81086436 Mouse 1302197 Bhr2_m bronchial hyperresponsiveness 2 (mouse) Not determined 15 64306334 103425899 Mouse 4141135 Cia35_m collagen induced arthritis 35 (mouse) Not determined 15 64811826 98811946 Mouse 1301119 Drb7_m dopamine receptor binding 7 (mouse) Not determined 15 65336578 99341028 Mouse 1301171 Brm2_m brachyury modifier 2 (mouse) Not determined 15 65525376 99525499 Mouse 4141921 Pstc3_m periosteal circumference 3 (mouse) Not determined 15 67270698 101270847 Mouse 1300627 Sluc26_m susceptibility to lung cancer 26 (mouse) Not determined 15 70345653 104073951 Mouse 1300648 Dbsty4_m diabesity 4 (mouse) Not determined 15 70349271 104073951 Mouse 1300726 Pitm4_m prion incubation time 4 (mouse) Not determined 15 70349271 104073951 Mouse 25671381 Hrsq3_m host response to SARS QTL 3, eosinophilia (mouse) 15 72144539 75844833 Mouse 1300844 Emo2_m emotionality 2 (mouse) Not determined 15 72372459 76794493 Mouse 1302002 Cocia2_m cocaine induced activation 2 (mouse) Not determined 15 72372459 79899178 Mouse 14747011 Mancz13_m mandible centroid size 13 (mouse) 15 72382669 104073951 Mouse 12791003 Aath8_m aortic arch atherosclerosis 8 (mouse) 15 73430144 104073951 Mouse 15092079 Igly6_m IgG glycosylation 6, GP6 (mouse) 15 74100540 82674156 Mouse 13442492 Mecth2_m mechanosensation threshold 2 (mouse) 15 74662849 79387201 Mouse
