| 71035 | Cpb2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity; INVOLVED IN cellular response to glucose stimulus; fibrinolysis; liver regeneration; PARTICIPATES IN fibrinolysis pathway; coagulation cascade pathway; complement system pathway; ASSOCIATED WITH Bacteremia; Burns; Chemical and Drug Induced L iver Injury; FOUND IN extracellular space; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 15 | 56967128 | 57015964 | Rat | 143 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 731734 | CPB2 | carboxypeptidase B2 | Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidas e B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] | 13 | 46053186 | 46105033 | Human | 146 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736000 | Cpb2 | carboxypeptidase B2 | This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016] | 14 | 75479727 | 75520995 | Mouse | 171 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 9037785 | Cpb2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | NW_004955518 | 3740348 | 3803540 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11931570 | CPB2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | 13 | 26926788 | 26979767 | Bonobo | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12118174 | CPB2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | 22 | 5074805 | 5126635 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12544551 | Cpb2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | NW_004936857 | 577067 | 609855 | Squirrel | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236798 | cpb2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625973681 | Cpb2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18498077 | CPB2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902940 | Cpb2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14202957 | CPB2 | carboxypeptidase B2 | ENCODES a protein that exhibits carboxypeptidase activity (ortholog); INVOLVED IN cellular response to glucose stimulus (ortholog); fibrinolysis (ortholog); liver regeneration (ortholog); PARTICIPATES IN fibrinolysis pathway; ASSOCIATED WITH amenorrhea (ortholog); Angina Pectoris (ortholog); Bactere mia (ortholog); FOUND IN extracellular space (ortholog) | | | | Pig | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155236799 | cpb2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155253495 | cpb2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 5130804 | CPB2-AS1 | CPB2 antisense RNA 1 | Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. [provided by Alliance of Genome Resources, Jul 2025] | 13 | 46052848 | 46101347 | Human | 7 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1549975 | Capzb | capping actin protein of muscle Z-line subunit beta | This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 4 | 138920210 | 139019131 | Mouse | 172 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |