| 2388 | Cpa1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity; metallocarboxypeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process; response to cadmium ion; leukotriene metabolic process (ortholog); ASSOCIATED WITH Cadmium Poisoning; chronic pancreatitis (ortholog); cy stic fibrosis (ortholog); FOUND IN extracellular space (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether | 4 | 60224801 | 60230928 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733563 | CPA1 | carboxypeptidase A1 | This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chr omosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015] | 7 | 130380494 | 130388108 | Human | 141 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 733564 | Cpa1 | carboxypeptidase A1, pancreatic | This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016] | 6 | 30639217 | 30645360 | Mouse | 108 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8762260 | Cpa1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); metallocarboxypeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracellular space (ortholog) | NW_004955479 | 11011928 | 11017908 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12041938 | CPA1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracel lular region (inferred); extracellular space (inferred) | 7 | 122335250 | 122353369 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12360439 | CPA1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracel lular region (inferred); extracellular space (inferred) | 14 | 6562729 | 6569298 | Dog | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12590405 | Cpa1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracel lular region (inferred); extracellular space (inferred) | NW_004936579 | 4897225 | 4903409 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930213 | Cpa1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracel lular region (inferred); extracellular space (inferred) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626084281 | Cpa1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); metallocarboxypeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); Hereditary Pancreatitis (ortholog); FOUND IN extracellular space (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14008028 | CPA1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); metallocarboxypeptidase activity (ortholog); INVOLVED IN leukotriene metabolic process (ortholog); proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (or tholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH zearalenone; zinc atom; zinc oxide | | | | Pig | 31 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18387849 | CPA1 | carboxypeptidase A1 | ENCODES a protein that exhibits exopeptidase activity (ortholog); INVOLVED IN proteolysis involved in protein catabolic process (ortholog); response to cadmium ion (ortholog); ASSOCIATED WITH Cadmium Poisoning (ortholog); chronic pancreatitis (ortholog); cystic fibrosis (ortholog); FOUND IN extracel lular region (inferred); extracellular space (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239684 | cpa1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155231170 | cpa1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155239683 | cpa1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12216556 | CPA2 | carboxypeptidase A2 | ENCODES a protein that exhibits carboxypeptidase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN proteolysis (inferred); ASSOCIATED WITH Hypoxia (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | 14 | 6645142 | 6665716 | Dog | 19 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |