Cox10 Gene Search Result

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16 records found for search term Cox10

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1321106	COX10	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits e ... (more) ncoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion. [provided by RefSeq, Jul 2008]	17	14069504	14208677	Human	217	symbol , old_gene_name , COSMIC , name , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1321107	Cox10	heme A:farnesyltransferase cytochrome c oxidase assembly factor 10	Enables protoheme IX farnesyltransferase activity. Involved in heme O biosynthetic process. Acts upstream of or within several processes, including copper ion homeostasis; heme A biosynthetic process; and mitochondrial fission. Located in mitochondrion. Is active in mitochondrial matrix. Is expresse ... (more) d in alimentary system; nervous system; respiratory system; and submandibular gland primordium. Used to study Parkinson's disease; cytochrome-c oxidase deficiency disease; and mitochondrial myopathy. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 3. Orthologous to human COX10 (cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10). [provided by Alliance of Genome Resources, Apr 2025]	11	63853453	63970298	Mouse	162	symbol , old_gene_name , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1594623	Cox10	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (ortholog); protoheme IX farnesyltransferase activity (ortholog); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); PARTICIPATES IN acute intermittent por ... (more) phyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; atrazine	10	49130209	49242009	Rat	108	symbol , old_gene_name , PhenoGen , name	gene, protein-coding, VALIDATED [RefSeq]
12361943	COX10	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (inferred); prenyltransferase activity (inferred); protoheme IX farnesyltransferase activity (inferred); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); ... (more) PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial matrix (inferred)	5	37853495	37982228	Dog	44	symbol , old_gene_name , name	gene, protein-coding, MODEL [RefSeq]
14371639	COX10						Yeast		symbol	gene, null
13889863	COX10	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (inferred); prenyltransferase activity (inferred); protoheme IX farnesyltransferase activity (inferred); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); ... (more) PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial matrix (inferred); INTERACTS WITH deoxynivalenol				Pig	46	symbol , old_gene_name , name	gene, protein-coding, VALIDATED [RefSeq]
287814292	cox10						Tropical Clawed Frog		symbol	gene, null
18622559	COX10	cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (inferred); prenyltransferase activity (inferred); protoheme IX farnesyltransferase activity (inferred); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); ... (more) PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial matrix (inferred)				Green Monkey	46	symbol , old_gene_name , name	gene, protein-coding, MODEL [RefSeq]
284133431	cox10.L						African Clawed Frog		symbol	gene, null
284371657	cox10.S						African Clawed Frog		symbol	gene, null
6481261	COX10-DT	COX10 divergent transcript	ASSOCIATED WITH cytochrome-c oxidase deficiency disease; INTERACTS WITH 2-hydroxypropanoic acid; rac-lactic acid; sodium dodecyl sulfate	17	14029292	14069458	Human	4	symbol , old_gene_name , COSMIC , name , Human Proteome Map , old_gene_symbol	gene, ncrna, VALIDATED [RefSeq]
18932752	LOC101726271	protoheme IX farnesyltransferase, mitochondrial	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (ortholog); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; here ... (more) ditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (ortholog)				Naked Mole-Rat	45	old_gene_symbol	gene, protein-coding, MODEL [RefSeq]
16552626	AC005838.1	pseudogene fragment similar to COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (COX10)					Human		name	gene, unprocessed_pseudogene
16554066	AL355355.1	pseudogene similar to part of COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (COX10)					Human		name	gene, processed_pseudogene
11936438	LOC100980340	protoheme IX farnesyltransferase, mitochondrial	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (inferred); prenyltransferase activity (inferred); protoheme IX farnesyltransferase activity (inferred); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); ... (more) PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (inferred); membrane (inferred); mitochondrial matrix (inferred)	17	37443319	37582436	Bonobo	46	ensembl_gene_symbol	gene, protein-coding, MODEL [RefSeq]
8950268	LOC102022268	protoheme IX farnesyltransferase, mitochondrial	ENCODES a protein that exhibits geranylgeranyl diphosphate synthase activity (ortholog); protoheme IX farnesyltransferase activity (ortholog); INVOLVED IN aerobic respiration (ortholog); copper ion homeostasis (ortholog); cytochrome complex assembly (ortholog); PARTICIPATES IN acute intermittent por ... (more) phyria pathway; erythropoietic porphyria pathway; hereditary coproporphyria pathway; ASSOCIATED WITH cytochrome-c oxidase deficiency disease (ortholog); genetic disease (ortholog); Leigh disease (ortholog); FOUND IN cytochrome complex (ortholog); mitochondrial matrix (ortholog); mitochondrion (ortholog)	NW_004955467	3294200	3415778	Chinchilla	32	ensembl_gene_symbol	gene, protein-coding, MODEL [RefSeq]