| 2364 | Cltc | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding; heat shock protein binding; peptide binding; INVOLVED IN Golgi organization; mitotic cell cycle; receptor-mediated endocytosis; PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; endocytosis pathway; ASSO CIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat; extrinsic component of synaptic vesicle membrane; sarcolemma; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene | 10 | 72014984 | 72073308 | Rat | 256 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 732795 | CLTC | clathrin heavy chain | Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathri n coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008] | 17 | 59619895 | 59696956 | Human | 345 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 737521 | Cltc | clathrin heavy chain | Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coat ed pit. Part of membrane coat. Is active in several cellular components, including photoreceptor ribbon synapse; postsynaptic endocytic zone; and presynaptic endocytic zone membrane. Is expressed in several structures, including brain; early embryo; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 86585178 | 86648637 | Mouse | 231 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9063866 | Cltc | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); clathrin light chain binding (ortholog); disordered domain specific binding (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); clathrin coat assembly (ortholog); clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); clathrin complex (ortholog); clathrin-coated pit (ortholog) | NW_004955451 | 3380304 | 3445973 | Chinchilla | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11705807 | CLTC | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); heat shock protein binding (ortholog); peptide binding (ortholog); INVOLVED IN Golgi organization (ortholog); mitotic spindle assembly (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 17 | 53685865 | 53761008 | Bonobo | 108 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12264621 | CLTC | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); heat shock protein binding (ortholog); peptide binding (ortholog); INVOLVED IN Golgi organization (ortholog); mitotic spindle assembly (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | 9 | 34116344 | 34183023 | Dog | 101 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12479305 | Cltc | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); heat shock protein binding (ortholog); peptide binding (ortholog); INVOLVED IN Golgi organization (ortholog); mitotic spindle assembly (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | NW_004936490 | 3659682 | 3726222 | Squirrel | 103 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928167 | Cltc | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); disordered domain specific binding (ortholog); double-stranded RNA binding (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); clathrin-dependent endocytosis (ortholog); Golgi organization (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); clathrin-coated vesicle (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 100 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242258 | cltc | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14137564 | CLTC | clathrin heavy chain | ENCODES a protein that exhibits disordered domain specific binding; ankyrin binding (ortholog); heat shock protein binding (ortholog); INVOLVED IN Golgi organization (ortholog); mitotic spindle assembly (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin-coated vesicle; cytosol; clathrin coat (ortholog) | | | | Pig | 82 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18506045 | CLTC | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); heat shock protein binding (ortholog); peptide binding (ortholog); INVOLVED IN Golgi organization (ortholog); mitotic spindle assembly (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); extrinsic component of synaptic vesicle membrane (ortholog); glutamatergic synapse (ortholog) | | | | Green Monkey | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625950047 | Cltc | clathrin heavy chain | ENCODES a protein that exhibits ankyrin binding (ortholog); clathrin light chain binding (ortholog); disordered domain specific binding (ortholog); INVOLVED IN amyloid-beta clearance by transcytosis (ortholog); clathrin coat assembly (ortholog); clathrin-dependent endocytosis (ortholog); PARTICIPATE S IN clathrin-dependent synaptic vesicle endocytosis; FasL mediated signaling pathway; ASSOCIATED WITH autosomal dominant intellectual developmental disorder (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); Developmental Disabilities (ortholog); FOUND IN clathrin coat (ortholog); clathrin complex (ortholog); clathrin-coated pit (ortholog) | | | | Black Rat | 90 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242259 | cltc.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155254746 | cltc.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1350184 | CLTCL1 | clathrin heavy chain like 1 | This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encodi ng different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] | 22 | 19179473 | 19291719 | Human | 105 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 8781290 | Cltcl1 | clathrin heavy chain like 1 | INVOLVED IN mitotic cell cycle (ortholog); positive regulation of D-glucose import across plasma membrane (ortholog); receptor-mediated endocytosis (ortholog); ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN clathrin-coated pit (ortholog); clathrin-coated vesicle (ortholo g); coated vesicle (ortholog) | NW_004955442 | 18688019 | 18803458 | Chinchilla | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11942699 | CLTCL1 | clathrin heavy chain like 1 | ENCODES a protein that exhibits clathrin light chain binding (inferred); structural molecule activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN early endosome (ortholog); plasma membrane (ortholog); recycling en dosome (ortholog) | 22 | 1934948 | 2050159 | Bonobo | 45 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12213672 | CLTCL1 | clathrin heavy chain like 1 | ENCODES a protein that exhibits clathrin light chain binding (inferred); structural molecule activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN early endosome (ortholog); plasma membrane (ortholog); recycling en dosome (ortholog); INTERACTS WITH mocetinostat | 26 | 29907235 | 30002136 | Dog | 39 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12732851 | Cltcl1 | clathrin heavy chain like 1 | ENCODES a protein that exhibits clathrin light chain binding (inferred); structural molecule activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN early endosome (ortholog); plasma membrane (ortholog); recycling en dosome (ortholog) | NW_004936619 | 3181890 | 3276305 | Squirrel | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286323976 | cltcl1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18454517 | CLTCL1 | clathrin heavy chain like 1 | ENCODES a protein that exhibits clathrin light chain binding (inferred); structural molecule activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); ASSOCIATED WITH autistic disorder (ortholog); COVID-19 (ortholog); FOUND IN early endosome (ortholog); plasma membrane (ortholog); recycling en dosome (ortholog) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288057240 | cltcl1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285446942 | cltcl1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 18900509 | LOC101708690 | clathrin heavy chain 2 | ENCODES a protein that exhibits clathrin light chain binding (inferred); structural molecule activity (inferred); INVOLVED IN intracellular protein transport (inferred); receptor-mediated endocytosis (inferred); vesicle-mediated transport (inferred); FOUND IN clathrin coat of coated pit (inferred); clathrin coat of trans-Golgi network vesicle (inferred); clathrin complex (inferred) | | | | Naked Mole-Rat | 19 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1353820 | ALK | ALK receptor tyrosine kinase | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the developme nt of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011] | 2 | 29192774 | 29921586 | Human | 593 | description | gene, protein-coding, REVIEWED [RefSeq] |
| 16571483 | AC000072.1 | novel transcript, antisense to CLTCL1 | | 22 | 19196644 | 19200089 | Human | | name | gene, ncrna, MODEL [RefSeq] |