| 620322 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport; positive regulation of calcium ion transport; transepithelial transport; PARTICIPATES IN hepatitis C pathw ay; ASSOCIATED WITH hypertension; genetic disease (ortholog); Hypercalciuria (ortholog); FOUND IN bicellular tight junction; tight junction (ortholog); INTERACTS WITH bisphenol A; tributylstannane; vinclozolin | 11 | 87795106 | 87814396 | Rat | 85 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 733040 | Cldn16 | claudin 16 | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cel l sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010] | 16 | 26281885 | 26301515 | Mouse | 92 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 1351544 | CLDN16 | claudin 16 | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of cont inuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28. [provided by RefSeq, Jun 2010] | 3 | 190290361 | 190412138 | Human | 165 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8896979 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport (ortholog); positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); ASSOCIATE D WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | NW_004955420 | 17684752 | 17714639 | Chinchilla | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11668443 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | 3 | 187141710 | 187436909 | Bonobo | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12239235 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | 34 | 22392108 | 22414250 | Dog | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12507243 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | NW_004936578 | 5774 | 25621 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245840 | cldn16 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18406474 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934713 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); transepithelial transport (ortholog); ASSOCI ATED WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | | | | Naked Mole-Rat | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626019446 | Cldn16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (ortholog); paracellular tight junction channel activity (ortholog); PDZ domain binding (ortholog); INVOLVED IN paracellular transport (ortholog); positive regulation of calcium ion transport (ortholog); renal absorption (ortholog); ASSOCIATE D WITH genetic disease (ortholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog); tight junction (ortholog) | | | | Black Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14070464 | CLDN16 | claudin 16 | ENCODES a protein that exhibits identical protein binding (inferred); paracellular tight junction channel activity (inferred); PDZ domain binding (inferred); INVOLVED IN positive regulation of calcium ion transport (ortholog); transepithelial transport (ortholog); ASSOCIATED WITH genetic disease (or tholog); Hypercalciuria (ortholog); hypertension (ortholog); FOUND IN bicellular tight junction (ortholog) | | | | Pig | 38 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 405859161 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863667 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859916 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865601 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626467916 | cldn16.S | | | | | | African Clawed Frog | | symbol | gene, null |
