| 1305379 | Clcn6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); INVOLVED IN response to mechanical stimulus; chloride transport (ortholog); ASSOCIATED WITH decreased body weight; decreased heart weight; decreased mean systemic arterial blood pressure; ASSOCIATED WITH coronary art ery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscinosis 15 (ortholog); FOUND IN late endosome membrane (inferred); membrane (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 5 | 163715593 | 163748301 | Rat | 110 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1313372 | CLCN6 | chloride voltage-gated channel 6 | This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012] | 1 | 11806191 | 11843130 | Human | 157 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1313373 | Clcn6 | chloride channel, voltage-sensitive 6 | This gene encodes a member of the ClC chloride channel and transporter family of proteins. The encoded protein may function as a vesicular Cl-/H+ antiporter. Homozygous knockout mice exhibit decreased pain sensitivity, behavioral abnormalities and features of lysosomal storage disease. [provided by RefSeq, Aug 2015] | 4 | 148088716 | 148123270 | Mouse | 111 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8746054 | Clcn6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); INVOLVED IN chloride transport (ortholog); response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscinosis 15 (ort holog) | NW_004955486 | 2066317 | 2096317 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11737930 | CLCN6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN late endosome membrane (inferred); lysosomal membrane (inferred); membrane (inferred) | 1 | 10568222 | 10605459 | Bonobo | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12287260 | CLCN6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN endosome membrane (inferred); late endosome membrane (inferred); membrane (inferred) | 2 | 84410740 | 84443874 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12608941 | Clcn6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN late endosome membrane (inferred); lysosomal membrane (inferred); membrane (inferred) | NW_004936474 | 637930 | 669383 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928258 | Clcn6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN late endosome membrane (inferred); lysosomal membrane (inferred); membrane (inferred) | | | | Naked Mole-Rat | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626119578 | Clcn6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits voltage-gated chloride channel activity (ortholog); INVOLVED IN chloride transport (ortholog); response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscinosis 15 (ort holog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247823 | clcn6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13998513 | CLCN6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN endosome membrane (inferred); late endosome membrane (inferred); membrane (inferred) | | | | Pig | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18585968 | CLCN6 | chloride voltage-gated channel 6 | ENCODES a protein that exhibits antiporter activity (inferred); ATP binding (inferred); chloride channel activity (inferred); INVOLVED IN response to mechanical stimulus (ortholog); ASSOCIATED WITH coronary artery disease (ortholog); Developmental Disabilities (ortholog); neuronal ceroid lipofuscino sis 15 (ortholog); FOUND IN late endosome membrane (inferred); lysosomal membrane (inferred); membrane (inferred) | | | | Green Monkey | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155252593 | clcn6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 5687740 | Clcn6em2Mcwi | chloride channel 6; zinc finger nuclease induced mutant 2, Medical College of Wisconsin | This allele was made by ZFN mutagenesis. The resulting mutation is a 15-bp frameshift deletion in exon 13 (del 1180-1194) | | | | Rat | | symbol , old_gene_symbol | gene, allele |
