| 69281 | Chrna6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding; acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); behavioral response to nicotine (ortholog); membrane depolarization (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN postsynaptic membrane; presynaptic membrane; protein-containing complex; INTERACTS WITH ammonium chloride; bisphenol A; chlorpyrifos | 16 | 71400615 | 71407315 | Rat | 123 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 733511 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmi ssion and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010] | 8 | 42752620 | 42768786 | Human | 115 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736285 | Chrna6 | cholinergic receptor, nicotinic, alpha polypeptide 6 | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in behavioral response to nicotine and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within membrane depolarization and regulation of dopamine secretion. Part of acetylcholine-gated cha nnel complex. Is active in dopaminergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in alcohol use disorder; cocaine abuse; and nicotine dependence. Orthologous to human CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 27893240 | 27903972 | Mouse | 113 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8737732 | Chrna6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); behavioral response to nicotine (ortholog); membrane depolarization (ortholog); PART ICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); dopaminergic synapse (ortholog); postsynaptic membrane (ortholog) | NW_004955536 | 166212 | 172551 | Chinchilla | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11847647 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); membrane depolarization (ortholog); presynaptic modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic ace tylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | 8 | 42000748 | 42016913 | Bonobo | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12150794 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); membrane depolarization (ortholog); regulation of dopamine secretion (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASS OCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | 16 | 22990377 | 23009257 | Dog | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12458047 | Chrna6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN membrane depolarization (ortholog); regulation of dopamine secretion (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog) ; cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN protein-containing complex (ortholog) | NW_004936785 | 17588 | 28565 | Squirrel | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 152177956 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 626125400 | Chrna6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); behavioral response to nicotine (ortholog); membrane depolarization (ortholog); PART ICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); dopaminergic synapse (ortholog); postsynaptic membrane (ortholog) | | | | Black Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913017 | Chrna6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); behavioral response to nicotine (ortholog); membrane depolarization (ortholog); PART ICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); dopaminergic synapse (ortholog); postsynaptic membrane (ortholog) | | | | Naked Mole-Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241981 | chrna6 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14080340 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); membrane depolarization (ortholog); regulation of dopamine secretion (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASS OCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18518363 | CHRNA6 | cholinergic receptor nicotinic alpha 6 subunit | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); membrane depolarization (ortholog); presynaptic modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic ace tylcholine receptor; ASSOCIATED WITH alcohol use disorder (ortholog); cocaine abuse (ortholog); nicotine dependence (ortholog); FOUND IN dopaminergic synapse (ortholog); postsynaptic membrane (ortholog); presynaptic membrane (ortholog) | | | | Green Monkey | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241980 | chrna6.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155900756 | Chrna6em1Slot | cholinergic receptor nicotinic alpha 6 subunit, CRISPR/Cas9 induced mutant 1, Slot | Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new geneti cally modified CHRNA6C123G allele carries homozygous GG nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. | | | | Rat | | symbol , description | gene, allele |
| 155900759 | Chrna6em2Slot | cholinergic receptor nicotinic alpha 6 subunit, CRISPR/Cas9 induced mutant 2, Slot | Using CRISPR/Cas9 genomic engineering in rats via homologous end-joining in fertilized embryos, we have knocked'in a humanized CHRNA6 3'UTR in place of the natural CHRNA6 3'UTR of the Sprague Dawley rat line. This new geneti cally modified CHRNA6C123G allele carries homozygous CC nucleotide modification at position 123 within the CHRNA6 gene 3'UTR. | | | | Rat | | symbol , description | gene, allele |