| 620874 | Chi3l1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitin binding (ortholog); chitinase activity (ortholog); INVOLVED IN cellular response to interleukin-1; cellular response to tumor necrosis factor; inflammatory response; PARTICIPATES IN amino sugar metabolic pathway; nucleotide sugar metabolic pathway; ASSOCIATED W ITH albuminuria; salt-sensitive hypertension; ASSOCIATED WITH hypertension; acute myeloid leukemia (ortholog); arteriosclerosis (ortholog); FOUND IN extracellular space; cytoplasm (ortholog); endoplasmic reticulum (ortholog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate | 13 | 48193839 | 48201822 | Rat | 267 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732419 | CHI3L1 | chitinase 3 like 1 | Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The pr otein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009] | 1 | 203178931 | 203186704 | Human | 263 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1552317 | Chi3l1 | chitinase 3 like 1 | Predicted to enable chitin binding activity. Involved in positive regulation of macromolecule metabolic process and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in endoplasmic reticulum. Is expressed in several structures, including alimentary sy stem; genitourinary system; limb; liver; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 134109894 | 134117769 | Mouse | 269 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8787693 | Chi3l1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitin binding (ortholog); chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leuke mia (ortholog); arteriosclerosis (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog) | NW_004955406 | 39195101 | 39201808 | Chinchilla | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11711191 | CHI3L1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arterioscle rosis (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog) | 1 | 178778081 | 178789704 | Bonobo | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12286886 | CHI3L1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitin binding (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arteriosclerosi s (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog) | 7 | 25620 | 32954 | Dog | 76 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12491900 | Chi3l1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arterioscle rosis (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog) | NW_004936567 | 1411080 | 1418332 | Squirrel | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18775313 | CHI3L1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arterioscle rosis (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14167067 | CHI3L1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitin binding (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arteriosclerosi s (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog); INTERACTS WITH deoxynivalenol; resveratrol | | | | Pig | 93 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626009806 | Chi3l1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitin binding (ortholog); chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leuke mia (ortholog); arteriosclerosis (ortholog); asthma (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog) | | | | Black Rat | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18923284 | Chi3l1 | chitinase 3 like 1 | ENCODES a protein that exhibits chitinase activity (ortholog); INVOLVED IN activation of NF-kappaB-inducing kinase activity (ortholog); cellular response to interleukin-1 (ortholog); cellular response to tumor necrosis factor (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); arterioscle rosis (ortholog); asthma (ortholog); FOUND IN extracellular space (ortholog) | | | | Naked Mole-Rat | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |