CHI3L1 (chitinase 3 like 1) - Rat Genome Database
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Gene: CHI3L1 (chitinase 3 like 1) Homo sapiens
Analyze
Symbol: CHI3L1
Name: chitinase 3 like 1
RGD ID: 732419
HGNC Page HGNC
Description: Exhibits chitin binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; response to interleukin-1; and response to interleukin-6. Localizes to extracellular space. Implicated in asthma and schizophrenia. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bone cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 39 kDa synovial protein; ASRT7; cartilage glycoprotein 39; CGP-39; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,178,931 - 203,186,704 (-)EnsemblGRCh38hg38GRCh38
GRCh381203,178,931 - 203,186,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,148,059 - 203,155,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,414,682 - 201,422,545 (-)NCBINCBI36hg18NCBI36
Build 341199,879,586 - 199,887,534NCBI
Celera1176,277,300 - 176,285,163 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,313,188 - 174,321,051 (-)NCBIHuRef
CHM1_11204,570,380 - 204,578,243 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
etoposide  (EXP)
furan  (ISO)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (EXP)
ketamine  (ISO)
methylmercury chloride  (EXP,ISO)
naphthalene  (ISO)
nickel dichloride  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
pentanal  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tungsten  (ISO)
valproic acid  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Bergmann OJ, etal., Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8644-52.
2. Boot RG, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):687-94.
3. Brasso K, etal., Prostate. 2006 Apr 1;66(5):503-13.
4. Chupp GL, etal., N Engl J Med. 2007 Nov 15;357(20):2016-27.
5. Cintin C, etal., Cancer. 2002 Jul 15;95(2):267-74.
6. Diefenbach CS, etal., Gynecol Oncol. 2007 Feb;104(2):435-42. Epub 2006 Oct 4.
7. GOA_HUMAN data from the GO Consortium
8. Hogdall EV, etal., Oncol Rep. 2003 Sep-Oct;10(5):1535-8.
9. Huang Y, etal., Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15044-9.
10. Jin Z, etal., Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):740-6.
11. Johansen JS, etal., Arthritis Rheum. 1999 Dec;42(12):2624-30.
12. Johansen JS, etal., Breast Cancer Res Treat. 2003 Jul;80(1):15-21.
13. Johansen JS, etal., Lung Cancer. 2004 Dec;46(3):333-40.
14. Johansen JS, etal., Respir Med. 2005 Apr;99(4):396-402. Epub 2004 Nov 5.
15. Johansen JS, etal., Rheumatology (Oxford). 1999 Jul;38(7):618-26.
16. Korthagen NM, etal., Respir Med. 2011 Jan;105(1):106-13.
17. Kucur M, etal., Coron Artery Dis. 2007 Aug;18(5):391-6.
18. Lee CG, etal., J Exp Med. 2009 May 11;206(5):1149-66. Epub 2009 May 4.
19. Madazli R, etal., Int J Gynaecol Obstet. 2008 Mar;100(3):239-43. Epub 2007 Dec 3.
20. Markert JM, etal., Physiol Genomics. 2001 Feb 7;5(1):21-33.
21. Matsuura H, etal., Am J Respir Cell Mol Biol. 2010 Jul 23.
22. Mylin AK, etal., Eur J Haematol. 2006 Nov;77(5):416-24. Epub 2006 Aug 23.
23. Nojgaard C, etal., Coron Artery Dis. 2008 Jun;19(4):257-63.
24. Nordenbaek C, etal., J Infect Dis. 1999 Nov;180(5):1722-6.
25. Nordenbaek C, etal., Scand J Rheumatol. 2005 Jul-Aug;34(4):293-7.
26. OMIM Disease Annotation Pipeline
27. Ostergaard C, etal., Clin Diagn Lab Immunol. 2002 May;9(3):598-604.
28. Pipeline to import KEGG annotations from KEGG into RGD
29. Rathcke CN, etal., Diabetes Care. 2009 Feb;32(2):323-8. Epub 2008 Oct 28.
30. Rathcke CN, etal., PLoS One. 2009 Jul 1;4(7):e6106.
31. Rathcke CN, etal., Scand Cardiovasc J. 2010 Apr;44(2):92-9.
32. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. RGD automated import pipeline for gene-chemical interactions
34. Schmidt H, etal., Cancer. 2006 Mar 1;106(5):1130-9.
35. Sjogren H, etal., Am J Pathol. 2003 Mar;162(3):781-92.
36. Sohn MH, etal., Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. Epub 2010 Jun 17.
37. Thom I, etal., Cancer. 2010 Sep 1;116(17):4114-21.
38. Thomsen SB, etal., Cardiovasc Diabetol. 2010 Dec 8;9:86.
39. Waki H, etal., Auton Neurosci. 2008 Nov 3;142(1-2):40-4. Epub 2008 Aug 13.
40. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:2375755   PMID:8125298   PMID:8245017   PMID:9244440   PMID:9417865   PMID:9492324   PMID:10772238   PMID:12069012   PMID:12071845   PMID:12435396   PMID:12477932   PMID:12759455  
PMID:12775711   PMID:12799184   PMID:12851408   PMID:12933821   PMID:12957359   PMID:14555515   PMID:14702039   PMID:15489334   PMID:15569925   PMID:15788675   PMID:15829322   PMID:15867231  
PMID:16234240   PMID:16344560   PMID:16502470   PMID:16818690   PMID:16955240   PMID:16960935   PMID:17020973   PMID:17160890   PMID:17236752   PMID:17543889   PMID:17545529   PMID:17565739  
PMID:17599744   PMID:17631744   PMID:17712177   PMID:17957792   PMID:18092325   PMID:18157633   PMID:18182077   PMID:18190830   PMID:18217402   PMID:18280741   PMID:18281018   PMID:18403759  
PMID:18490894   PMID:18570155   PMID:18615353   PMID:18650368   PMID:18708058   PMID:18723551   PMID:18767121   PMID:18802121   PMID:19003601   PMID:19070929   PMID:19089918   PMID:19106306  
PMID:19197227   PMID:19200605   PMID:19255724   PMID:19264973   PMID:19308408   PMID:19421404   PMID:19536175   PMID:19550125   PMID:19644363   PMID:19666003   PMID:19694834   PMID:19701838  
PMID:19765801   PMID:19767768   PMID:20012147   PMID:20047081   PMID:20051317   PMID:20056225   PMID:20099501   PMID:20174854   PMID:20224722   PMID:20226308   PMID:20237129   PMID:20300754  
PMID:20347092   PMID:20356987   PMID:20424473   PMID:20499402   PMID:20506295   PMID:20538957   PMID:20540736   PMID:20640910   PMID:20650887   PMID:20674561   PMID:20800603   PMID:20840668  
PMID:20926018   PMID:20943784   PMID:20961744   PMID:20972697   PMID:21029458   PMID:21159401   PMID:21159721   PMID:21257319   PMID:21258804   PMID:21272568   PMID:21385870   PMID:21391238  
PMID:21478032   PMID:21496058   PMID:21530869   PMID:21642896   PMID:21714862   PMID:21715039   PMID:21782391   PMID:21820815   PMID:21831900   PMID:21858537   PMID:21873635   PMID:21934681  
PMID:21949714   PMID:21953450   PMID:21968467   PMID:21978279   PMID:22036069   PMID:22056877   PMID:22074331   PMID:22095223   PMID:22103814   PMID:22140133   PMID:22146624   PMID:22183936  
PMID:22209020   PMID:22209156   PMID:22211103   PMID:22281830   PMID:22351690   PMID:22366530   PMID:22433444   PMID:22480951   PMID:22525348   PMID:22534532   PMID:22554524   PMID:22572101  
PMID:22583189   PMID:22628227   PMID:22642467   PMID:22647735   PMID:22655594   PMID:22809439   PMID:22937056   PMID:22955689   PMID:22986489   PMID:22989351   PMID:23071724   PMID:23149946  
PMID:23170831   PMID:23190377   PMID:23197259   PMID:23226395   PMID:23227243   PMID:23272150   PMID:23279705   PMID:23291472   PMID:23294528   PMID:23364142   PMID:23376485   PMID:23397672  
PMID:23490418   PMID:23501042   PMID:23525579   PMID:23533145   PMID:23551676   PMID:23562456   PMID:23573226   PMID:23591413   PMID:23613996   PMID:23628340   PMID:23665676   PMID:23671604  
PMID:23706599   PMID:23792508   PMID:23840582   PMID:23874603   PMID:23918300   PMID:23972995   PMID:24062521   PMID:24256818   PMID:24309227   PMID:24324091   PMID:24405178   PMID:24440516  
PMID:24442412   PMID:24498368   PMID:24512683   PMID:24572981   PMID:24582001   PMID:24650028   PMID:24685381   PMID:24689875   PMID:24691276   PMID:24729664   PMID:24730590   PMID:24801872  
PMID:24808626   PMID:24814404   PMID:24842123   PMID:24861484   PMID:24878721   PMID:24920662   PMID:24954373   PMID:24958781   PMID:24981110   PMID:24996799   PMID:25001061   PMID:25024322  
PMID:25047113   PMID:25051073   PMID:25056157   PMID:25068525   PMID:25128003   PMID:25139333   PMID:25142236   PMID:25172968   PMID:25172979   PMID:25187353   PMID:25203433   PMID:25225167  
PMID:25230316   PMID:25262987   PMID:25270518   PMID:25304157   PMID:25343670   PMID:25400457   PMID:25412935   PMID:25421412   PMID:25486056   PMID:25497736   PMID:25519006   PMID:25545245  
PMID:25573204   PMID:25592985   PMID:25624368   PMID:25629266   PMID:25629580   PMID:25657159   PMID:25688078   PMID:25698171   PMID:25740558   PMID:25760838   PMID:25875173   PMID:25909875  
PMID:25941933   PMID:25955771   PMID:25976273   PMID:26002577   PMID:26095694   PMID:26121745   PMID:26125767   PMID:26142786   PMID:26186194   PMID:26197239   PMID:26270969   PMID:26275425  
PMID:26295543   PMID:26301577   PMID:26303257   PMID:26310833   PMID:26316585   PMID:26372680   PMID:26382922   PMID:26415140   PMID:26427144   PMID:26431492   PMID:26452028   PMID:26466985  
PMID:26523896   PMID:26603717   PMID:26620310   PMID:26696093   PMID:26698298   PMID:26698539   PMID:26733160   PMID:26779637   PMID:26781979   PMID:26782508   PMID:26828595   PMID:26935740  
PMID:26988273   PMID:26988593   PMID:27013031   PMID:27069189   PMID:27090900   PMID:27121858   PMID:27152377   PMID:27170664   PMID:27179219   PMID:27187575   PMID:27193312   PMID:27374825  
PMID:27385098   PMID:27427920   PMID:27575987   PMID:27616735   PMID:27629921   PMID:27650381   PMID:27653898   PMID:27668705   PMID:27732738   PMID:27739482   PMID:27760764   PMID:27801851  
PMID:27815265   PMID:27832767   PMID:27881022   PMID:27977409   PMID:27977724   PMID:28009325   PMID:28036271   PMID:28053085   PMID:28099248   PMID:28143526   PMID:28211584   PMID:28260989  
PMID:28281838   PMID:28285848   PMID:28303416   PMID:28324830   PMID:28368410   PMID:28384116   PMID:28448439   PMID:28514442   PMID:28567534   PMID:28569052   PMID:28599675   PMID:28624692  
PMID:28639986   PMID:28660216   PMID:28681574   PMID:28697565   PMID:28711881   PMID:28739286   PMID:28797750   PMID:28932021   PMID:28941940   PMID:28989002   PMID:29025889   PMID:29028081  
PMID:29112186   PMID:29126445   PMID:29209110   PMID:29233108   PMID:29274508   PMID:29324810   PMID:29336711   PMID:29357700   PMID:29396296   PMID:29400369   PMID:29427412   PMID:29430175  
PMID:29452694   PMID:29580282   PMID:29642772   PMID:29643433   PMID:29729901   PMID:29737637   PMID:29783062   PMID:29797629   PMID:29804188   PMID:29806605   PMID:29848684   PMID:29921378  
PMID:29949801   PMID:29970479   PMID:29981861   PMID:30019588   PMID:30061245   PMID:30077474   PMID:30111325   PMID:30121622   PMID:30165890   PMID:30223258   PMID:30224549   PMID:30258444  
PMID:30301907   PMID:30341592   PMID:30402955   PMID:30431458   PMID:30471784   PMID:30523734   PMID:30560917   PMID:30584894   PMID:30660494   PMID:30688121   PMID:30940096   PMID:30948312  
PMID:30952886   PMID:30978656   PMID:30988078   PMID:31021016   PMID:31092426   PMID:31115541   PMID:31231798   PMID:31247206   PMID:31256192   PMID:31310926   PMID:31397016   PMID:31427175  
PMID:31482369   PMID:31487401   PMID:31490625   PMID:31536166   PMID:31563729   PMID:31685562   PMID:31856080   PMID:31937582   PMID:32066474   PMID:32162865   PMID:32170669   PMID:32276601  
PMID:32279122   PMID:32312371   PMID:32613636  


Genomics

Comparative Map Data
CHI3L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1203,178,931 - 203,186,704 (-)EnsemblGRCh38hg38GRCh38
GRCh381203,178,931 - 203,186,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371203,148,059 - 203,155,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,414,682 - 201,422,545 (-)NCBINCBI36hg18NCBI36
Build 341199,879,586 - 199,887,534NCBI
Celera1176,277,300 - 176,285,163 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1174,313,188 - 174,321,051 (-)NCBIHuRef
CHM1_11204,570,380 - 204,578,243 (-)NCBICHM1_1
Chil1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,109,894 - 134,117,769 (+)NCBIGRCm39mm39
GRCm39 Ensembl1134,109,914 - 134,117,919 (+)Ensembl
GRCm381134,182,156 - 134,190,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,182,176 - 134,190,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371136,078,981 - 136,086,608 (+)NCBIGRCm37mm9NCBIm37
MGSCv361135,998,892 - 136,006,442 (+)NCBImm8
Celera1136,794,910 - 136,802,547 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
Chi3l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21345,641,802 - 45,649,787 (+)NCBI
Rnor_6.0 Ensembl1351,022,681 - 51,030,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01351,022,844 - 51,030,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01356,074,912 - 56,086,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,139,658 - 47,147,591 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11347,155,099 - 47,161,151 (+)NCBI
Celera1345,969,872 - 45,977,855 (+)NCBICelera
Cytogenetic Map13q13NCBI
Chi3l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,191,073 - 39,202,020 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,195,101 - 39,201,808 (-)NCBIChiLan1.0ChiLan1.0
CHI3L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11183,073,287 - 183,083,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,075,312 - 183,083,229 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01178,778,081 - 178,789,704 (-)NCBIMhudiblu_PPA_v0panPan3
CHI3L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl726,316 - 33,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1725,620 - 32,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Chi3l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365671,411,080 - 1,418,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHI3L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,885,542 - 113,895,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,885,541 - 113,895,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,344,018 - 125,353,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHI3L1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,160,993 - 26,169,005 (+)NCBI
ChlSab1.1 Ensembl2526,160,961 - 26,169,566 (+)Ensembl
Chi3l1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248077,655,777 - 7,664,484 (+)NCBI

Position Markers
SHGC-76167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,148,102 - 203,148,218UniSTSGRCh37
Build 361201,414,725 - 201,414,841RGDNCBI36
Celera1176,277,343 - 176,277,459RGD
Cytogenetic Map1q32.1UniSTS
HuRef1174,313,231 - 174,313,347UniSTS
TNG Radiation Hybrid Map133681.0UniSTS
GeneMap99-GB4 RH Map1670.77UniSTS
NCBI RH Map11732.6UniSTS
CHI3L1_4566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,147,823 - 203,148,712UniSTSGRCh37
Build 361201,414,446 - 201,415,335RGDNCBI36
Celera1176,277,064 - 176,277,953RGD
HuRef1174,312,952 - 174,313,841UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1298
Count of miRNA genes:595
Interacting mature miRNAs:661
Transcripts:ENST00000255409, ENST00000404436, ENST00000472064, ENST00000473185, ENST00000478742
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2 3 86 43 6 38 15 3 107 16 11 5 15 5
Medium 535 1330 904 442 1063 324 2648 506 2529 207 477 994 118 944 1529 1
Low 1386 1310 634 116 627 77 1326 1155 1001 166 720 430 40 243 1062 1
Below cutoff 472 334 93 16 169 20 337 516 71 32 211 115 6 2 192 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_013056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA167112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000255409   ⟹   ENSP00000255409
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,178,931 - 203,186,704 (-)Ensembl
RefSeq Acc Id: ENST00000404436   ⟹   ENSP00000385350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,178,981 - 203,182,805 (-)Ensembl
RefSeq Acc Id: ENST00000472064
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,179,998 - 203,182,841 (-)Ensembl
RefSeq Acc Id: ENST00000473185
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,178,931 - 203,182,134 (-)Ensembl
RefSeq Acc Id: ENST00000478742
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1203,179,134 - 203,180,133 (-)Ensembl
RefSeq Acc Id: NM_001276   ⟹   NP_001267
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
GRCh371203,148,059 - 203,155,978 (-)NCBI
Build 361201,414,682 - 201,422,545 (-)NCBI Archive
HuRef1174,313,188 - 174,321,051 (-)ENTREZGENE
CHM1_11204,570,380 - 204,578,243 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001267   ⟸   NM_001276
- Peptide Label: precursor
- UniProtKB: P36222 (UniProtKB/Swiss-Prot),   A0A024R969 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000255409   ⟸   ENST00000255409
RefSeq Acc Id: ENSP00000385350   ⟸   ENST00000404436
Protein Domains
GH18   Glyco_18

Promoters
RGD ID:6851316
Promoter ID:EP73456
Type:multiple initiation site
Name:HS_CHI3L1
Description:Chitinase 3-like 1 (cartilage glycoprotein-39).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361201,422,354 - 201,422,414EPD
RGD ID:6858626
Promoter ID:EPDNEW_H2478
Type:initiation region
Name:CHI3L1_1
Description:chitinase 3 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,186,703 - 203,186,763EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001276.2(CHI3L1):c.-131C>G single nucleotide variant Asthma-related traits, susceptibility to, 7 [RCV000008580] Chr1:203186754 [GRCh38]
Chr1:203155882 [GRCh37]
Chr1:1q32.1
risk factor
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13
pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44
pathogenic
GRCh37/hg19 1q32.1(chr1:203134126-203160335)x3 copy number gain See cases [RCV000448399] Chr1:203134126..203160335 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41
pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44
pathogenic
GRCh37/hg19 1q32.1(chr1:203078722-203210585)x1 copy number loss not provided [RCV001005167] Chr1:203078722..203210585 [GRCh37]
Chr1:1q32.1
uncertain significance
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2
not provided
NM_001276.4(CHI3L1):c.348C>A (p.Arg116=) single nucleotide variant not provided [RCV000888394] Chr1:203183758 [GRCh38]
Chr1:203152886 [GRCh37]
Chr1:1q32.1
benign
NM_001276.4(CHI3L1):c.723G>A (p.Val241=) single nucleotide variant not provided [RCV000910342] Chr1:203180641 [GRCh38]
Chr1:203149769 [GRCh37]
Chr1:1q32.1
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1932 AgrOrtholog
COSMIC CHI3L1 COSMIC
Ensembl Genes ENSG00000133048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000255409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000385350 UniProtKB/TrEMBL
Ensembl Transcript ENST00000255409 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000404436 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000133048 GTEx
HGNC ID HGNC:1932 ENTREZGENE
Human Proteome Map CHI3L1 Human Proteome Map
InterPro CHI3L1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chitinase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chitinase_insertion_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_hydro18_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1116 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1116 ENTREZGENE
OMIM 181500 OMIM
  601525 OMIM
  611960 OMIM
PANTHER PTHR11177:SF202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26463 PharmGKB
PROSITE GH18_2 UniProtKB/Swiss-Prot
SMART Glyco_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R969 ENTREZGENE, UniProtKB/TrEMBL
  CH3L1_HUMAN UniProtKB/Swiss-Prot
  H0Y3U8_HUMAN UniProtKB/TrEMBL
  P36222 ENTREZGENE
  Q9NY39_HUMAN UniProtKB/TrEMBL
  Q9NY40_HUMAN UniProtKB/TrEMBL
  Q9NY41_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R7B0 UniProtKB/Swiss-Prot
  P30923 UniProtKB/Swiss-Prot
  Q8IVA4 UniProtKB/Swiss-Prot
  Q96HI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 CHI3L1  chitinase 3 like 1    chitinase 3-like 1 (cartilage glycoprotein-39)  Symbol and/or name change 5135510 APPROVED