CHI3L1 (chitinase 3 like 1) - Rat Genome Database

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Gene: CHI3L1 (chitinase 3 like 1) Homo sapiens
Analyze
Symbol: CHI3L1
Name: chitinase 3 like 1
RGD ID: 732419
HGNC Page HGNC:1932
Description: Enables chitin binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; response to interleukin-1; and response to interleukin-6. Located in extracellular space. Implicated in asthma and schizophrenia. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); hematologic cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 39 kDa synovial protein; ASRT7; cartilage glycoprotein 39; CGP-39; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase-3-like protein 1; DKFZp686N19119; FLJ38139; GP-39; GP39; HC-gp39; hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,178,931 - 203,186,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,178,931 - 203,186,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371203,148,059 - 203,155,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,414,682 - 201,422,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 341199,879,586 - 199,887,534NCBI
Celera1176,277,300 - 176,285,163 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,313,188 - 174,321,051 (-)NCBIHuRef
CHM1_11204,570,380 - 204,578,243 (-)NCBICHM1_1
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP)
alpha-pinene  (EXP)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (EXP)
antirheumatic drug  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
ethanol  (ISO)
etoposide  (EXP)
fentanyl  (ISO)
fulvestrant  (EXP)
furan  (ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (EXP)
ketamine  (ISO)
Mesaconitine  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP,ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nickel dichloride  (ISO)
nitrofen  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
pentanal  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (ISO)
sulfadimethoxine  (ISO)
Sunset Yellow FCF  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
triadimefon  (EXP,ISO)
tributylstannane  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
tungsten  (ISO)
valproic acid  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia. Bergmann OJ, etal., Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8644-52.
2. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Boot RG, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):687-94.
3. Prognostic value of PINP, bone alkaline phosphatase, CTX-I, and YKL-40 in patients with metastatic prostate carcinoma. Brasso K, etal., Prostate. 2006 Apr 1;66(5):503-13.
4. A chitinase-like protein in the lung and circulation of patients with severe asthma. Chupp GL, etal., N Engl J Med. 2007 Nov 15;357(20):2016-27.
5. High serum YKL-40 level after surgery for colorectal carcinoma is related to short survival. Cintin C, etal., Cancer. 2002 Jul 15;95(2):267-74.
6. Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer. Diefenbach CS, etal., Gynecol Oncol. 2007 Feb;104(2):435-42. Epub 2006 Oct 4.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. High plasma YKL-40 level in patients with ovarian cancer stage III is related to shorter survival. Hogdall EV, etal., Oncol Rep. 2003 Sep-Oct;10(5):1535-8.
9. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Huang Y, etal., Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15044-9.
10. Identification of differentially expressed genes in rat silicosis model by suppression subtractive hybridization analysis. Jin Z, etal., Acta Biochim Biophys Sin (Shanghai). 2008 Aug;40(8):740-6.
11. YKL-40 in giant cells and macrophages from patients with giant cell arteritis. Johansen JS, etal., Arthritis Rheum. 1999 Dec;42(12):2624-30.
12. High serum YKL-40 levels in patients with primary breast cancer is related to short recurrence free survival. Johansen JS, etal., Breast Cancer Res Treat. 2003 Jul;80(1):15-21.
13. High serum YKL-40 level in patients with small cell lung cancer is related to early death. Johansen JS, etal., Lung Cancer. 2004 Dec;46(3):333-40.
14. Increased serum YKL-40 in patients with pulmonary sarcoidosis--a potential marker of disease activity? Johansen JS, etal., Respir Med. 2005 Apr;99(4):396-402. Epub 2004 Nov 5.
15. Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity. Johansen JS, etal., Rheumatology (Oxford). 1999 Jul;38(7):618-26.
16. Serum and BALF YKL-40 levels are predictors of survival in idiopathic pulmonary fibrosis. Korthagen NM, etal., Respir Med. 2011 Jan;105(1):106-13.
17. Serum YKL-40 levels in patients with coronary artery disease. Kucur M, etal., Coron Artery Dis. 2007 Aug;18(5):391-6.
18. Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. Lee CG, etal., J Exp Med. 2009 May 11;206(5):1149-66. Epub 2009 May 4.
19. Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies. Madazli R, etal., Int J Gynaecol Obstet. 2008 Mar;100(3):239-43. Epub 2007 Dec 3.
20. Differential gene expression profiling in human brain tumors. Markert JM, etal., Physiol Genomics. 2001 Feb 7;5(1):21-33.
21. Role of Breast Regression Protein (BRP)-39 in the Pathogenesis of Cigarette Smoke-Induced Inflammation and Emphysema. Matsuura H, etal., Am J Respir Cell Mol Biol. 2010 Jul 23.
22. Serum YKL-40 concentrations in newly diagnosed multiple myeloma patients and YKL-40 expression in malignant plasma cells. Mylin AK, etal., Eur J Haematol. 2006 Nov;77(5):416-24. Epub 2006 Aug 23.
23. Serum levels of YKL-40 increases in patients with acute myocardial infarction. Nojgaard C, etal., Coron Artery Dis. 2008 Jun;19(4):257-63.
24. YKL-40, a matrix protein of specific granules in neutrophils, is elevated in serum of patients with community-acquired pneumonia requiring hospitalization. Nordenbaek C, etal., J Infect Dis. 1999 Nov;180(5):1722-6.
25. High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement. Nordenbaek C, etal., Scand J Rheumatol. 2005 Jul-Aug;34(4):293-7.
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. YKL-40 is elevated in cerebrospinal fluid from patients with purulent meningitis. Ostergaard C, etal., Clin Diagn Lab Immunol. 2002 May;9(3):598-604.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. YKL-40, a marker of inflammation and endothelial dysfunction, is elevated in patients with type 1 diabetes and increases with levels of albuminuria. Rathcke CN, etal., Diabetes Care. 2009 Feb;32(2):323-8. Epub 2008 Oct 28.
30. Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults. Rathcke CN, etal., PLoS One. 2009 Jul 1;4(7):e6106.
31. Plasma YKL-40 levels are elevated in patients with chronic heart failure. Rathcke CN, etal., Scand Cardiovasc J. 2010 Apr;44(2):92-9.
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Elevated serum level of YKL-40 is an independent prognostic factor for poor survival in patients with metastatic melanoma. Schmidt H, etal., Cancer. 2006 Mar 1;106(5):1130-9.
35. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses. Sjogren H, etal., Am J Pathol. 2003 Mar;162(3):781-92.
36. The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury. Sohn MH, etal., Am J Respir Crit Care Med. 2010 Oct 1;182(7):918-28. Epub 2010 Jun 17.
37. Elevated pretreatment serum concentration of YKL-40-An independent prognostic biomarker for poor survival in patients with metastatic nonsmall cell lung cancer. Thom I, etal., Cancer. 2010 Sep 1;116(17):4114-21.
38. Increased levels of the calcification marker matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease. Thomsen SB, etal., Cardiovasc Diabetol. 2010 Dec 8;9:86.
39. Gene expression profiles of major cytokines in the nucleus tractus solitarii of the spontaneously hypertensive rat. Waki H, etal., Auton Neurosci. 2008 Nov 3;142(1-2):40-4. Epub 2008 Aug 13.
40. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
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PMID:33352356   PMID:33471078   PMID:33486888   PMID:33508452   PMID:33622872   PMID:33652290   PMID:33664231   PMID:33764958   PMID:33870790   PMID:33888584   PMID:33920100   PMID:33961781  
PMID:33991015   PMID:34020736   PMID:34088622   PMID:34110111   PMID:34164774   PMID:34168643   PMID:34170085   PMID:34228644   PMID:34259106   PMID:34274729   PMID:34417838   PMID:34432260  
PMID:34436040   PMID:34498339   PMID:34526107   PMID:34579512   PMID:34612767   PMID:34627195   PMID:34637032   PMID:34657273   PMID:34669813   PMID:34747367   PMID:34790051   PMID:34871165  
PMID:34935995   PMID:34942410   PMID:34952935   PMID:35022663   PMID:35033868   PMID:35042079   PMID:35144413   PMID:35178615   PMID:35222369   PMID:35234337   PMID:35239952   PMID:35340006  
PMID:35342020   PMID:35466129   PMID:35533232   PMID:35534236   PMID:35534648   PMID:35622011   PMID:35761288   PMID:35761838   PMID:35788062   PMID:35813465   PMID:35837962   PMID:35853494  
PMID:35879733   PMID:35896264   PMID:35951428   PMID:35952618   PMID:35960307   PMID:36215168   PMID:36228382   PMID:36241524   PMID:36244672   PMID:36276655   PMID:36332693   PMID:36359773  
PMID:36417796   PMID:36428997   PMID:36447423   PMID:36478333   PMID:36560606   PMID:36618349   PMID:36642504   PMID:36716730   PMID:36724073   PMID:36768925   PMID:36898474   PMID:37088328  
PMID:37166517   PMID:37192383   PMID:37215572   PMID:37655481   PMID:37690071   PMID:37866952   PMID:37902124   PMID:37958973   PMID:38003487   PMID:38036279   PMID:38039967   PMID:38062768  
PMID:38159969   PMID:38290090   PMID:38290591   PMID:38320988   PMID:38533556   PMID:38634621   PMID:38667293   PMID:38733586   PMID:38900045   PMID:39291933   PMID:39408927  


Genomics

Comparative Map Data
CHI3L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381203,178,931 - 203,186,704 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1203,178,931 - 203,186,704 (-)EnsemblGRCh38hg38GRCh38
GRCh371203,148,059 - 203,155,832 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361201,414,682 - 201,422,545 (-)NCBINCBI36Build 36hg18NCBI36
Build 341199,879,586 - 199,887,534NCBI
Celera1176,277,300 - 176,285,163 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1174,313,188 - 174,321,051 (-)NCBIHuRef
CHM1_11204,570,380 - 204,578,243 (-)NCBICHM1_1
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBIT2T-CHM13v2.0
Chi3l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391134,109,894 - 134,117,769 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1134,109,914 - 134,117,919 (+)EnsemblGRCm39 Ensembl
GRCm381134,182,156 - 134,190,031 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1134,182,176 - 134,190,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv371136,078,981 - 136,086,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,998,892 - 136,006,442 (+)NCBIMGSCv36mm8
Celera1136,794,910 - 136,802,547 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.15NCBI
Chi3l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81348,193,839 - 48,201,822 (+)NCBIGRCr8
mRatBN7.21345,641,802 - 45,649,787 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1345,641,802 - 45,649,787 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1348,249,911 - 48,257,861 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01349,537,967 - 49,545,918 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01346,802,803 - 46,810,792 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,022,844 - 51,030,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,022,681 - 51,030,802 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01356,074,912 - 56,086,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41347,139,658 - 47,147,591 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11347,155,099 - 47,161,151 (+)NCBI
Celera1345,969,872 - 45,977,855 (+)NCBICelera
Cytogenetic Map13q13NCBI
Chi3l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540639,191,073 - 39,202,020 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540639,195,101 - 39,201,808 (-)NCBIChiLan1.0ChiLan1.0
CHI3L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2146,191,248 - 46,200,704 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1146,155,762 - 46,166,214 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01178,778,081 - 178,789,704 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11183,073,287 - 183,083,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1183,075,312 - 183,083,229 (-)Ensemblpanpan1.1panPan2
CHI3L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1725,620 - 32,954 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl726,316 - 33,427 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha782,048 - 88,664 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0736,653 - 43,433 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl736,715 - 43,899 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1725,021 - 31,646 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07134,620 - 141,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07157,023 - 163,649 (+)NCBIUU_Cfam_GSD_1.0
Chi3l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934472,176,383 - 72,183,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365671,411,037 - 1,418,801 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365671,411,080 - 1,418,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHI3L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9113,885,542 - 113,895,131 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19113,885,541 - 113,895,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29125,344,018 - 125,353,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CHI3L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12526,160,993 - 26,169,005 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2526,160,961 - 26,169,566 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605526,937,390 - 26,945,433 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chi3l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248077,655,620 - 7,662,362 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248077,655,777 - 7,664,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CHI3L1
42 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001276.2(CHI3L1):c.-131C>G single nucleotide variant Asthma-related traits, susceptibility to, 7 [RCV000008580] Chr1:203186754 [GRCh38]
Chr1:203155882 [GRCh37]
Chr1:1q32.1		 risk factor
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1q32.1(chr1:203134126-203160335)x3 copy number gain See cases [RCV000448399] Chr1:203134126..203160335 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_001276.4(CHI3L1):c.199G>A (p.Asp67Asn) single nucleotide variant not specified [RCV004308356] Chr1:203185242 [GRCh38]
Chr1:203154370 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
GRCh37/hg19 1q32.1(chr1:203078722-203210585)x1 copy number loss not provided [RCV001005167] Chr1:203078722..203210585 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-32.2(chr1:194356425-210988710)x3 copy number gain not provided [RCV001249273] Chr1:194356425..210988710 [GRCh37]
Chr1:1q31.3-32.2		 not provided
NM_001276.4(CHI3L1):c.1088T>G (p.Phe363Cys) single nucleotide variant not specified [RCV004292971] Chr1:203179509 [GRCh38]
Chr1:203148637 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.158A>T (p.His53Leu) single nucleotide variant not specified [RCV004301289] Chr1:203185283 [GRCh38]
Chr1:203154411 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.348C>A (p.Arg116=) single nucleotide variant not provided [RCV000888394] Chr1:203183758 [GRCh38]
Chr1:203152886 [GRCh37]
Chr1:1q32.1		 benign
NM_001276.4(CHI3L1):c.723G>A (p.Val241=) single nucleotide variant not provided [RCV000910342] Chr1:203180641 [GRCh38]
Chr1:203149769 [GRCh37]
Chr1:1q32.1		 benign
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
NM_001276.4(CHI3L1):c.616T>C (p.Tyr206His) single nucleotide variant not specified [RCV004610327] Chr1:203181257 [GRCh38]
Chr1:203150385 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.998G>T (p.Ser333Ile) single nucleotide variant not specified [RCV004610328] Chr1:203179774 [GRCh38]
Chr1:203148902 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(206945780_?)dup duplication Epilepsy, familial adult myoclonic, 5 [RCV003116306] Chr1:200522516..206945780 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_200522516)_(208391267_?)dup duplication Hypokalemic periodic paralysis, type 1 [RCV003119239]|not provided [RCV003119240] Chr1:200522516..208391267 [GRCh37]
Chr1:1q32.1-32.2		 uncertain significance|no classifications from unflagged records
NM_001276.4(CHI3L1):c.1082G>A (p.Gly361Asp) single nucleotide variant not specified [RCV004281694] Chr1:203179515 [GRCh38]
Chr1:203148643 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-44(chr1:197867914-249224684)x3 copy number gain See cases [RCV002287837] Chr1:197867914..249224684 [GRCh37]
Chr1:1q31.3-44		 pathogenic
NM_001276.4(CHI3L1):c.61G>A (p.Ala21Thr) single nucleotide variant not specified [RCV004325119] Chr1:203185380 [GRCh38]
Chr1:203154508 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.526G>A (p.Ala176Thr) single nucleotide variant not specified [RCV004183831] Chr1:203182792 [GRCh38]
Chr1:203151920 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_001276.4(CHI3L1):c.671G>A (p.Arg224Gln) single nucleotide variant not specified [RCV004224142] Chr1:203181202 [GRCh38]
Chr1:203150330 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.388C>A (p.His130Asn) single nucleotide variant not specified [RCV004154570] Chr1:203183718 [GRCh38]
Chr1:203152846 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.13G>A (p.Ala5Thr) single nucleotide variant not specified [RCV004201129] Chr1:203186611 [GRCh38]
Chr1:203155739 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.476C>A (p.Ala159Asp) single nucleotide variant not specified [RCV004187310] Chr1:203182842 [GRCh38]
Chr1:203151970 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.779C>G (p.Thr260Ser) single nucleotide variant not specified [RCV004227016] Chr1:203180585 [GRCh38]
Chr1:203149713 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.14C>A (p.Ala5Glu) single nucleotide variant not specified [RCV004082439] Chr1:203186610 [GRCh38]
Chr1:203155738 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.689G>A (p.Ser230Asn) single nucleotide variant not specified [RCV004189581] Chr1:203181184 [GRCh38]
Chr1:203150312 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.371C>T (p.Pro124Leu) single nucleotide variant not specified [RCV004080008] Chr1:203183735 [GRCh38]
Chr1:203152863 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.782T>C (p.Phe261Ser) single nucleotide variant not specified [RCV004173312] Chr1:203180582 [GRCh38]
Chr1:203149710 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.112G>A (p.Asp38Asn) single nucleotide variant not specified [RCV004078852] Chr1:203185329 [GRCh38]
Chr1:203154457 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.767T>C (p.Met256Thr) single nucleotide variant not specified [RCV004094397] Chr1:203180597 [GRCh38]
Chr1:203149725 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.820G>A (p.Val274Ile) single nucleotide variant not specified [RCV004610329] Chr1:203180544 [GRCh38]
Chr1:203149672 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.950C>G (p.Pro317Arg) single nucleotide variant not specified [RCV004311164] Chr1:203179822 [GRCh38]
Chr1:203148950 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.14C>T (p.Ala5Val) single nucleotide variant not specified [RCV004256850] Chr1:203186610 [GRCh38]
Chr1:203155738 [GRCh37]
Chr1:1q32.1		 likely benign
NM_001276.4(CHI3L1):c.638G>A (p.Arg213His) single nucleotide variant not specified [RCV004261260] Chr1:203181235 [GRCh38]
Chr1:203150363 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.910C>T (p.Arg304Cys) single nucleotide variant not specified [RCV004260186] Chr1:203179862 [GRCh38]
Chr1:203148990 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.982T>C (p.Tyr328His) single nucleotide variant not specified [RCV004311504] Chr1:203179790 [GRCh38]
Chr1:203148918 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.540G>A (p.Ala180=) single nucleotide variant not specified [RCV004358984] Chr1:203182778 [GRCh38]
Chr1:203151906 [GRCh37]
Chr1:1q32.1		 likely benign
NM_001276.4(CHI3L1):c.1004A>G (p.Lys335Arg) single nucleotide variant not specified [RCV004348979] Chr1:203179768 [GRCh38]
Chr1:203148896 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.626A>G (p.His209Arg) single nucleotide variant not specified [RCV004357150] Chr1:203181247 [GRCh38]
Chr1:203150375 [GRCh37]
Chr1:1q32.1		 uncertain significance
GRCh37/hg19 1q31.3-32.1(chr1:197216705-203683110)x1 copy number loss not specified [RCV003986384] Chr1:197216705..203683110 [GRCh37]
Chr1:1q31.3-32.1		 likely pathogenic
GRCh37/hg19 1q32.1(chr1:199373229-204335027)x3 copy number gain not specified [RCV003986684] Chr1:199373229..204335027 [GRCh37]
Chr1:1q32.1		 likely pathogenic
NM_001276.4(CHI3L1):c.1040C>T (p.Ala347Val) single nucleotide variant not specified [RCV004439202] Chr1:203179557 [GRCh38]
Chr1:203148685 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.133G>A (p.Ala45Thr) single nucleotide variant not specified [RCV004439203] Chr1:203185308 [GRCh38]
Chr1:203154436 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.304G>T (p.Gly102Trp) single nucleotide variant not specified [RCV004439204] Chr1:203184586 [GRCh38]
Chr1:203153714 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.730A>C (p.Met244Leu) single nucleotide variant not specified [RCV004439211] Chr1:203180634 [GRCh38]
Chr1:203149762 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.689G>T (p.Ser230Ile) single nucleotide variant not specified [RCV004439210] Chr1:203181184 [GRCh38]
Chr1:203150312 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.86C>T (p.Thr29Ile) single nucleotide variant not specified [RCV004439212] Chr1:203185355 [GRCh38]
Chr1:203154483 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.539C>T (p.Ala180Val) single nucleotide variant not specified [RCV004439207] Chr1:203182779 [GRCh38]
Chr1:203151907 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.578A>G (p.Lys193Arg) single nucleotide variant not specified [RCV004439208] Chr1:203182740 [GRCh38]
Chr1:203151868 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.58T>G (p.Ser20Ala) single nucleotide variant not specified [RCV004439209] Chr1:203185383 [GRCh38]
Chr1:203154511 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.349C>T (p.Arg117Trp) single nucleotide variant not specified [RCV004439205] Chr1:203183757 [GRCh38]
Chr1:203152885 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.382C>T (p.Arg128Cys) single nucleotide variant not specified [RCV004439206] Chr1:203183724 [GRCh38]
Chr1:203152852 [GRCh37]
Chr1:1q32.1		 uncertain significance
NC_000001.10:g.(?_190829412)_(216061974_?)del deletion not provided [RCV004579260] Chr1:190829412..216061974 [GRCh37]
Chr1:1q31.2-41		 pathogenic
NM_001276.4(CHI3L1):c.937G>A (p.Gly313Ser) single nucleotide variant not specified [RCV004610325] Chr1:203179835 [GRCh38]
Chr1:203148963 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.1148C>T (p.Thr383Met) single nucleotide variant not specified [RCV004610326] Chr1:203179449 [GRCh38]
Chr1:203148577 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_001276.4(CHI3L1):c.258-2A>C single nucleotide variant Schizophrenia [RCV004764677] Chr1:203184634 [GRCh38]
Chr1:203153762 [GRCh37]
Chr1:1q32.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1298
Count of miRNA genes:595
Interacting mature miRNAs:661
Transcripts:ENST00000255409, ENST00000404436, ENST00000472064, ENST00000473185, ENST00000478742
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406894945GWAS543921_Hchitinase-3-like protein 1 measurement QTL GWAS543921 (human)7e-746chitinase-3-like protein 1 measurement1203184966203184967Human
406999440GWAS648416_Hlevel of chitinase-3-like protein 1 in blood serum QTL GWAS648416 (human)1e-28level of chitinase-3-like protein 1 in blood serum1203186575203186576Human
407285314GWAS934290_HYKL40 measurement QTL GWAS934290 (human)4e-303YKL40 measurement1203183673203183674Human
407287155GWAS936131_HYKL40 measurement QTL GWAS936131 (human)1e-187YKL40 measurement1203181771203181772Human
407290928GWAS939904_Hchitotriosidase-1 measurement QTL GWAS939904 (human)1e-18chitotriosidase-1 measurement1203186284203186285Human
406965720GWAS614696_Hlevel of chitinase-3-like protein 1 in blood serum QTL GWAS614696 (human)1e-30level of chitinase-3-like protein 1 in blood serum1203186575203186576Human
406949551GWAS598527_Hchitinase-3-like protein 1 measurement QTL GWAS598527 (human)1e-2203chitinase-3-like protein 1 measurement1203184506203184507Human

Markers in Region
SHGC-76167  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,148,102 - 203,148,218UniSTSGRCh37
Build 361201,414,725 - 201,414,841RGDNCBI36
Celera1176,277,343 - 176,277,459RGD
Cytogenetic Map1q32.1UniSTS
HuRef1174,313,231 - 174,313,347UniSTS
TNG Radiation Hybrid Map133681.0UniSTS
GeneMap99-GB4 RH Map1670.77UniSTS
NCBI RH Map11732.6UniSTS
CHI3L1_4566  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371203,147,823 - 203,148,712UniSTSGRCh37
Build 361201,414,446 - 201,415,335RGDNCBI36
Celera1176,277,064 - 176,277,953RGD
HuRef1174,312,952 - 174,313,841UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1204 2395 2788 2230 4916 1717 2281 4 617 1865 459 2239 7161 6363 43 3708 833 1707 1554 169

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_013056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047442879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054333994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ251847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK130200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034684 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX648308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA167112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M80927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y08378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000255409   ⟹   ENSP00000255409
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,178,931 - 203,186,704 (-)Ensembl
Ensembl Acc Id: ENST00000404436   ⟹   ENSP00000385350
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,178,981 - 203,182,805 (-)Ensembl
Ensembl Acc Id: ENST00000472064
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,179,998 - 203,182,841 (-)Ensembl
Ensembl Acc Id: ENST00000473185
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,178,931 - 203,182,134 (-)Ensembl
Ensembl Acc Id: ENST00000478742
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1203,179,134 - 203,180,133 (-)Ensembl
RefSeq Acc Id: NM_001276   ⟹   NP_001267
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
GRCh371203,148,059 - 203,155,978 (-)NCBI
Build 361201,414,682 - 201,422,545 (-)NCBI Archive
HuRef1174,313,188 - 174,321,051 (-)ENTREZGENE
CHM1_11204,570,380 - 204,578,243 (-)NCBI
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047442840   ⟹   XP_047298796
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442841   ⟹   XP_047298797
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442846   ⟹   XP_047298802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442847   ⟹   XP_047298803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442848   ⟹   XP_047298804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,178,931 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442873   ⟹   XP_047298829
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,181,162 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_047442879   ⟹   XP_047298835
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,181,556 - 203,186,704 (-)NCBI
RefSeq Acc Id: XM_054333988   ⟹   XP_054189963
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333989   ⟹   XP_054189964
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333990   ⟹   XP_054189965
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333991   ⟹   XP_054189966
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333992   ⟹   XP_054189967
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,441,684 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333993   ⟹   XP_054189968
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,443,915 - 202,449,457 (-)NCBI
RefSeq Acc Id: XM_054333994   ⟹   XP_054189969
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01202,444,309 - 202,449,457 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001267 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298796 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298797 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298802 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298803 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298804 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298829 (Get FASTA)   NCBI Sequence Viewer  
  XP_047298835 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189963 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189964 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189965 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189966 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189967 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189968 (Get FASTA)   NCBI Sequence Viewer  
  XP_054189969 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16074 (Get FASTA)   NCBI Sequence Viewer  
  AAH08568 (Get FASTA)   NCBI Sequence Viewer  
  AAH38354 (Get FASTA)   NCBI Sequence Viewer  
  AAH39132 (Get FASTA)   NCBI Sequence Viewer  
  AAP35887 (Get FASTA)   NCBI Sequence Viewer  
  BAD92696 (Get FASTA)   NCBI Sequence Viewer  
  BAG35757 (Get FASTA)   NCBI Sequence Viewer  
  BAG53058 (Get FASTA)   NCBI Sequence Viewer  
  CAA69661 (Get FASTA)   NCBI Sequence Viewer  
  CAB76472 (Get FASTA)   NCBI Sequence Viewer  
  EAW91467 (Get FASTA)   NCBI Sequence Viewer  
  EAW91468 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000255409
  ENSP00000255409.3
  ENSP00000385350.2
GenBank Protein P36222 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001267   ⟸   NM_001276
- Peptide Label: precursor
- UniProtKB: Q8IVA4 (UniProtKB/Swiss-Prot),   P30923 (UniProtKB/Swiss-Prot),   B2R7B0 (UniProtKB/Swiss-Prot),   Q96HI7 (UniProtKB/Swiss-Prot),   P36222 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000255409   ⟸   ENST00000255409
Ensembl Acc Id: ENSP00000385350   ⟸   ENST00000404436
RefSeq Acc Id: XP_047298804   ⟸   XM_047442848
- Peptide Label: isoform X5
RefSeq Acc Id: XP_047298802   ⟸   XM_047442846
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047298803   ⟸   XM_047442847
- Peptide Label: isoform X4
RefSeq Acc Id: XP_047298797   ⟸   XM_047442841
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047298796   ⟸   XM_047442840
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047298829   ⟸   XM_047442873
- Peptide Label: isoform X6
RefSeq Acc Id: XP_047298835   ⟸   XM_047442879
- Peptide Label: isoform X7
RefSeq Acc Id: XP_054189967   ⟸   XM_054333992
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054189965   ⟸   XM_054333990
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054189966   ⟸   XM_054333991
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054189964   ⟸   XM_054333989
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054189963   ⟸   XM_054333988
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054189968   ⟸   XM_054333993
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054189969   ⟸   XM_054333994
- Peptide Label: isoform X7
Protein Domains
GH18

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36222-F1-model_v2 AlphaFold P36222 1-383 view protein structure

Promoters
RGD ID:6851316
Promoter ID:EP73456
Type:multiple initiation site
Name:HS_CHI3L1
Description:Chitinase 3-like 1 (cartilage glycoprotein-39).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 361201,422,354 - 201,422,414EPD
RGD ID:6858626
Promoter ID:EPDNEW_H2478
Type:initiation region
Name:CHI3L1_1
Description:chitinase 3 like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381203,186,703 - 203,186,763EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1932 AgrOrtholog
COSMIC CHI3L1 COSMIC
Ensembl Genes ENSG00000133048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000255409 ENTREZGENE
  ENST00000255409.8 UniProtKB/Swiss-Prot
  ENST00000404436.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.10 UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000133048 GTEx
HGNC ID HGNC:1932 ENTREZGENE
Human Proteome Map CHI3L1 Human Proteome Map
InterPro Chitinase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chitinase_insertion_sf UniProtKB/Swiss-Prot
  Glyco_hydro18_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glycosyl_Hydrlase_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1116 UniProtKB/Swiss-Prot
NCBI Gene 1116 ENTREZGENE
OMIM 601525 OMIM
PANTHER CHITINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11177:SF202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_hydro_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26463 PharmGKB
PROSITE GH18_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Glyco_18 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54556 UniProtKB/Swiss-Prot
UniProt B2R7B0 ENTREZGENE
  CH3L1_HUMAN UniProtKB/Swiss-Prot
  H0Y3U8_HUMAN UniProtKB/TrEMBL
  P30923 ENTREZGENE
  P36222 ENTREZGENE
  Q8IVA4 ENTREZGENE
  Q96HI7 ENTREZGENE
  Q9NY39_HUMAN UniProtKB/TrEMBL
  Q9NY40_HUMAN UniProtKB/TrEMBL
  Q9NY41_HUMAN UniProtKB/TrEMBL
UniProt Secondary B2R7B0 UniProtKB/Swiss-Prot
  P30923 UniProtKB/Swiss-Prot
  Q8IVA4 UniProtKB/Swiss-Prot
  Q96HI7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 CHI3L1  chitinase 3 like 1    chitinase 3-like 1 (cartilage glycoprotein-39)  Symbol and/or name change 5135510 APPROVED