| 1306360 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog); INTERACTS WITH bisphenol A; cocaine; endosulfan | 12 | 52164214 | 52197860 | Rat | 103 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1314932 | CHFR | checkpoint with forkhead and ring finger domains | This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014] | 12 | 132832356 | 132887618 | Human | 96 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1314933 | Chfr | checkpoint with forkhead and ring finger domains | Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including positive regulation of protein metabolic process; protein destabilization; and protein polyubiquitination. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in embryo . Orthologous to human CHFR (checkpoint with forkhead and ring finger domains). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 110283599 | 110319839 | Mouse | 126 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8924018 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | NW_004955482 | 233485 | 267064 | Chinchilla | 25 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12116810 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | 26 | 251369 | 324699 | Dog | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12669488 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | NW_004936660 | 2725019 | 2754564 | Squirrel | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 32727218 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | 12 | 130318971 | 130366282 | Bonobo | 36 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 625947373 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); ubiquitin-protein transferase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); P ARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (ortholog); PML body (ortholog) | | | | Black Rat | 25 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18691099 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits metal ion binding (inferred); nucleotide binding (inferred); transferase activity (inferred); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquit ination (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Green Monkey | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14284993 | CHFR | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN mitotic cell cycle (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); positive regulation of protein ubiquitination (ortholog); PARTICIPATES IN ADP-ribosyla tion pathway, mono and poly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Pig | 37 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18932287 | Chfr | checkpoint with forkhead and ring finger domains | ENCODES a protein that exhibits nucleotide binding (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN meiotic spindle checkpoint signaling (ortholog); mitotic cell cycle (ortholog); mitotic G2/M transition checkpoint (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and p oly-ribosylation; ASSOCIATED WITH Endometrial Neoplasms (ortholog); lung non-small cell carcinoma (ortholog); Stomach Neoplasms (ortholog); FOUND IN nucleus (inferred); PML body (inferred) | | | | Naked Mole-Rat | 33 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155255133 | chfr | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155254962 | chfr.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155233720 | chfr.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16556590 | CHFR-DT | CHFR divergent transcript | | 12 | 132887842 | 132888571 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 6486962 | Chfr-ps1 | checkpoint with forkhead and ring finger domains, pseudogene 1 | | 7 | 136778472 | 136780108 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1583852 | Chfr-ps2 | checkpoint with forkhead and ring finger domains, pseudogene 2 | | 7 | 136686088 | 136691634 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 18936123 | LOC101708493 | E3 ubiquitin-protein ligase CHFR-like | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626043950 | LOC116890179 | E3 ubiquitin-protein ligase CHFR-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 402188354 | LOC134479802 | E3 ubiquitin-protein ligase CHFR-like | | 7 | 136894031 | 136895651 | Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 14204285 | ZNF605 | zinc finger protein 605 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); metal ion binding (inferred); INVOLVED IN cell division (inferred); chromatin remodeling (inferred); DNA-templated transcription (inferred); FOUND IN nucleopla sm (inferred); nucleus (inferred); PML body (inferred) | | | | Pig | 36 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |