| 1309884 | Cep57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); microtubule binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN fibroblast growth factor receptor signaling pathway (ortholog); protein homooligomerization (ortholog); spermatid development (orthol og); ASSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A | 8 | 18951179 | 18971205 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320468 | Cep57 | centrosomal protein 57 | Enables microtubule binding activity. Involved in protein homooligomerization and spermatid development. Located in centrosome; cytoplasm; and nucleus. Is expressed in midbrain ventricular layer and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in mosaic variegated aneup loidy syndrome 2. Orthologous to human CEP57 (centrosomal protein 57). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 13717979 | 13738698 | Mouse | 152 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1602500 | CEP57 | centrosomal protein 57 | This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for n ucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] | 11 | 95790014 | 95832693 | Human | 242 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8832245 | Cep57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); microtubule binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN fibroblast growth factor receptor signaling pathway (ortholog); protein homooligomerization (ortholog); spermatid development (orthol og); ASSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955412 | 638718 | 693837 | Chinchilla | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11897119 | CEP57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN fibroblast growth factor receptor signaling pathway (ortholog); protein homooligomerization (ortholog); spermatid development (ortholog); ASSOCIATED WITH genetic dis ease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); Golgi apparatus (ortholog) | 11 | 90795277 | 90838166 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12197979 | CEP57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); gamma-tubulin binding (inferred); identical protein binding (inferred); INVOLVED IN fibroblast growth factor receptor signaling pathway (inferred); protein homooligomerization (inferred); spermatid development (inferred); A SSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred) | 21 | 5314290 | 5360474 | Dog | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12547285 | Cep57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); gamma-tubulin binding (inferred); identical protein binding (inferred); INVOLVED IN fibroblast growth factor receptor signaling pathway (inferred); protein homooligomerization (inferred); spermatid development (inferred); A SSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936700 | 1874509 | 1914688 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14218498 | CEP57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); gamma-tubulin binding (inferred); identical protein binding (inferred); INVOLVED IN fibroblast growth factor receptor signaling pathway (inferred); protein homooligomerization (inferred); spermatid development (inferred); A SSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Pig | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18507626 | CEP57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (inferred); gamma-tubulin binding (inferred); identical protein binding (inferred); INVOLVED IN fibroblast growth factor receptor signaling pathway (inferred); protein homooligomerization (inferred); spermatid development (inferred); A SSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18910120 | Cep57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN fibroblast growth factor receptor signaling pathway (ortholog); protein homooligomerization (ortholog); spermatid development (ortholog); ASSOCIATED WITH genetic dis ease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); Golgi apparatus (ortholog) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235293 | cep57 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625975314 | Cep57 | centrosomal protein 57 | ENCODES a protein that exhibits fibroblast growth factor binding (ortholog); microtubule binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN fibroblast growth factor receptor signaling pathway (ortholog); protein homooligomerization (ortholog); spermatid development (orthol og); ASSOCIATED WITH genetic disease (ortholog); mosaic variegated aneuploidy syndrome (ortholog); mosaic variegated aneuploidy syndrome 1 (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155255985 | cep57.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232984 | cep57.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16553670 | AC009961.2 | centrosomal protein 57kDa (CEP57) pseudogene | | | | | Human | | name | gene, processed_pseudogene |
| 1311358 | Cep57l1 | centrosomal protein 57-like 1 | ENCODES a protein that exhibits identical protein binding (ortholog); FOUND IN centrosome (inferred); microtubule (inferred); INTERACTS WITH acetamide; furan; oxaliplatin | 20 | 46820350 | 46876911 | Rat | 54 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1347020 | CEP57L1 | centrosomal protein 57 like 1 | Enables identical protein binding activity. Predicted to be located in cytoplasm; microtubule; and microtubule organizing center. Predicted to be active in centrosome. [provided by Alliance of Genome Resources, Jul 2025] | 6 | 109095163 | 109174418 | Human | 57 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1551958 | Cep57l1 | centrosomal protein 57-like 1 | Predicted to enable identical protein binding activity and microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Predicted to be active in centrosome. Is expressed in adrenal gland; ovary; and testis. Orthologous to human CEP57L1 (c entrosomal protein 57 like 1). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 41594836 | 41686413 | Mouse | 60 | symbol , old_gene_name , PhenoGen , description , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 8770430 | Cep57l1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits identical protein binding (ortholog) | NW_004955411 | 34140830 | 34213086 | Chinchilla | 7 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11925996 | CEP57L1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | 6 | 106896158 | 106965644 | Bonobo | 14 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12427763 | CEP57L1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | 12 | 66058098 | 66133632 | Dog | 14 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12589806 | Cep57l1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | NW_004936564 | 5292214 | 5335112 | Squirrel | 14 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14009976 | CEP57L1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | | | | Pig | 14 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18614578 | CEP57L1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | | | | Green Monkey | 14 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18918832 | Cep57l1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | | | | Naked Mole-Rat | 13 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155259476 | cep57l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626065034 | Cep57l1 | centrosomal protein 57 like 1 | ENCODES a protein that exhibits identical protein binding (ortholog) | | | | Black Rat | 7 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155250722 | cep57l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1322775 | CEP57L1P1 | centrosomal protein 57 like 1 pseudogene 1 | | 10 | 70389366 | 70390166 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 11673195 | LOC100978367 | centrosomal protein CEP57L1-like | ENCODES a protein that exhibits gamma-tubulin binding (inferred); identical protein binding (inferred); microtubule binding (inferred); FOUND IN centrosome (inferred); microtubule (inferred) | 10 | 66864870 | 66866222 | Bonobo | 7 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |