Cdc45l Gene Search Result

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5 records found for search term Cdc45l

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
14370851	CDC45L						Fly		symbol	gene, null
1352573	CDC45	cell division cycle 45	The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance protei ... (more) ns (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]	22	19479466	19520612	Human	344	old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1557775	Cdc45	cell division cycle 45	Predicted to enable DNA replication origin binding activity; chromatin binding activity; and single-stranded DNA binding activity. Predicted to be involved in DNA replication initiation; double-strand break repair via break-induced replication; and mitotic DNA replication preinitiation complex assem ... (more) bly. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of CMG complex. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and notochord. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Jul 2025]	16	18599202	18632371	Mouse	203	old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
1590928	Cdc45	cell division cycle 45	INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH androgen insensitivity syndrome (ortholog); Androgen Insensitivity Syndrome due to Coactivator Deficiency (ortholog); COVID-19 (ortholog); FOUND IN ciliary basal body (ortholog); cytosol (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naph ... (more) thyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil	11	95689702	95714980	Rat	177	old_gene_symbol	gene, protein-coding, PROVISIONAL [RefSeq]
12161246	CDC45	cell division cycle 45	INVOLVED IN DNA replication (inferred); DNA replication initiation (inferred); ASSOCIATED WITH androgen insensitivity syndrome (ortholog); Androgen Insensitivity Syndrome due to Coactivator Deficiency (ortholog); COVID-19 (ortholog); FOUND IN ciliary basal body (inferred); cytosol (inferred); nucleo ... (more) plasm (inferred)	26	29707523	29738599	Dog	36	old_gene_symbol	gene, protein-coding, MODEL [RefSeq]