| 1311151 | Ccnt1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); chromatin binding (ortholog); cyclin-dependent protein serine/threonine kinase activator activity (ortholog); INVOLVED IN response to xenobiotic stimulus; host-mediated activation of viral transcription (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; congestive heart failure (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH berberine; bisphenol A; fenofibrate | 7 | 131566176 | 131596988 | Rat | 92 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1322457 | CCNT1 | cyclin T1 | This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] | 12 | 48688458 | 48716707 | Human | 119 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1322458 | Ccnt1 | cyclin T1 | Enables several functions, including chromatin binding activity; protein kinase binding activity; and transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation by host of viral transcription and positive regulation of transcription elongation by RNA polyme rase II. Predicted to act upstream of or within protein phosphorylation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; gonad; hemolymphoid system gland; and limb. Orthologous to human CCNT1 (cyclin T1). [provided by Alliance of Genome Resources, Jul 2025] | 15 | 98436570 | 98468340 | Mouse | 134 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8759651 | Ccnt1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); chromatin binding (ortholog); cyclin-dependent protein serine/threonine kinase activator activity (ortholog); INVOLVED IN host-mediated activation of viral transcription (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); positive regulation of transcription elongation by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | NW_004955500 | 7580625 | 7606913 | Chinchilla | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11787789 | CCNT1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); chromatin binding (inferred); cyclin-dependent protein serine/threonine kinase activator activity (inferred); INVOLVED IN response to xenobiotic stimulus (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSO CIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN nucleolus (ortholog); nucleus (ortholog) | 12 | 40028334 | 40057393 | Bonobo | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12351635 | CCNT1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); chromatin binding (inferred); cyclin-dependent protein serine/threonine kinase activator activity (inferred); INVOLVED IN response to xenobiotic stimulus (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSO CIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN nucleolus (ortholog) | 27 | 5788426 | 5817518 | Dog | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12470233 | Ccnt1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); chromatin binding (inferred); cyclin-dependent protein serine/threonine kinase activator activity (inferred); INVOLVED IN response to xenobiotic stimulus (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSO CIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN nucleolus (ortholog); nucleus (ortholog) | NW_004936512 | 6567663 | 6588107 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14044949 | CCNT1 | cyclin T1 | ENCODES a protein that exhibits chromatin binding (ortholog); protein kinase binding (ortholog); snRNA binding (ortholog); INVOLVED IN response to xenobiotic stimulus (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN nucleolus (ortholog) | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626119138 | Ccnt1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); chromatin binding (ortholog); cyclin-dependent protein serine/threonine kinase activator activity (ortholog); INVOLVED IN host-mediated activation of viral transcription (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); positive regulation of transcription elongation by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Black Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237408 | ccnt1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18935667 | Ccnt1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (ortholog); chromatin binding (ortholog); cyclin-dependent protein serine/threonine kinase activator activity (ortholog); INVOLVED IN host-mediated activation of viral transcription (ortholog); positive regulation of transcription by RNA polymerase I I (ortholog); positive regulation of transcription elongation by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSOCIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cyclin/CDK positive transcription elongation factor complex (ortholog); nucleolus (ortholog); nucleoplasm (ortholog) | | | | Naked Mole-Rat | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18502248 | CCNT1 | cyclin T1 | ENCODES a protein that exhibits 7SK snRNA binding (inferred); chromatin binding (inferred); cyclin-dependent protein serine/threonine kinase activator activity (inferred); INVOLVED IN response to xenobiotic stimulus (ortholog); PARTICIPATES IN RNA polymerase II transcription elongation pathway; ASSO CIATED WITH congestive heart failure (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN nucleolus (ortholog); nucleus (ortholog) | | | | Green Monkey | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155259765 | ccnt1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250597 | ccnt1.S | | | | | | African Clawed Frog | | symbol | gene, null |