CCNT1 (cyclin T1) - Rat Genome Database

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Gene: CCNT1 (cyclin T1) Homo sapiens
Analyze
Symbol: CCNT1
Name: cyclin T1
RGD ID: 1322457
HGNC Page HGNC
Description: Exhibits RNA polymerase binding activity; nucleic acid binding activity; and transcription factor binding activity. Involved in negative regulation of mRNA polyadenylation; positive regulation of transcription by RNA polymerase II; and protein phosphorylation. Localizes to P-TEFb complex and cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCNT; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1b; cyclin-T; cyclin-T1; CYCT1; DKFZp313A1331; DKFZp313N0919; DKFZp313O1211; FLJ11223; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1; Human immunodeficiency virus-1 expression; MLLT10/CCNT1 fusion; subunit of positive elongation transcription factor b
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Is Marker For: Strains:   F344-Tg(CCNT1)1Hik  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,688,458 - 48,716,998 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,688,458 - 48,716,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371249,082,241 - 49,110,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,373,019 - 47,397,048 (-)NCBINCBI36hg18NCBI36
Build 341247,373,018 - 47,397,048NCBI
Celera1247,882,748 - 47,906,759 (-)NCBI
Cytogenetic Map12q13.11-q13.12NCBI
HuRef1246,116,314 - 46,144,840 (-)NCBIHuRef
CHM1_11249,048,056 - 49,076,621 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7853496   PMID:8676484   PMID:8849451   PMID:9334325   PMID:9334326   PMID:9356449   PMID:9491887   PMID:9499409   PMID:9557739   PMID:9570510   PMID:9649438   PMID:9651670  
PMID:9696809   PMID:9765201   PMID:9811724   PMID:9832504   PMID:9843510   PMID:9872325   PMID:9990016   PMID:10049833   PMID:10066804   PMID:10077579   PMID:10082552   PMID:10329125  
PMID:10329126   PMID:10364292   PMID:10364329   PMID:10377393   PMID:10384302   PMID:10393184   PMID:10393900   PMID:10438593   PMID:10454543   PMID:10465067   PMID:10467404   PMID:10536359  
PMID:10545121   PMID:10574912   PMID:10617616   PMID:10656684   PMID:10661406   PMID:10671520   PMID:10757782   PMID:10866664   PMID:10903436   PMID:10913173   PMID:10931842   PMID:10944537  
PMID:10958691   PMID:10964778   PMID:10983978   PMID:10985245   PMID:11080476   PMID:11112772   PMID:11118314   PMID:11145967   PMID:11282025   PMID:11373315   PMID:11455589   PMID:11504720  
PMID:11545735   PMID:11547919   PMID:11549886   PMID:11673469   PMID:11689614   PMID:11689688   PMID:11704662   PMID:11713532   PMID:11713533   PMID:11730934   PMID:11739686   PMID:11739744  
PMID:11780068   PMID:11809800   PMID:11884399   PMID:12052871   PMID:12065898   PMID:12115727   PMID:12177005   PMID:12368300   PMID:12368330   PMID:12458222   PMID:12486002   PMID:12494448  
PMID:12588988   PMID:12591939   PMID:12651893   PMID:12676794   PMID:12727882   PMID:12753906   PMID:12832472   PMID:12883554   PMID:12887902   PMID:12894230   PMID:12917420   PMID:12942536  
PMID:12944466   PMID:12944920   PMID:14569024   PMID:14580347   PMID:14627702   PMID:14702039   PMID:14963154   PMID:14972556   PMID:14984439   PMID:15049426   PMID:15107825   PMID:15139295  
PMID:15142377   PMID:15169877   PMID:15183343   PMID:15201869   PMID:15328539   PMID:15473004   PMID:15498776   PMID:15528190   PMID:15546612   PMID:15563843   PMID:15638724   PMID:15713661  
PMID:15713662   PMID:15719065   PMID:15855166   PMID:15905409   PMID:15913611   PMID:15940264   PMID:15994294   PMID:15994812   PMID:16035254   PMID:16109376   PMID:16109377   PMID:16135803  
PMID:16146763   PMID:16308568   PMID:16330531   PMID:16362050   PMID:16439541   PMID:16601680   PMID:16615932   PMID:16687403   PMID:16764723   PMID:16781761   PMID:16838299   PMID:16893449  
PMID:16916647   PMID:16980611   PMID:17014716   PMID:17148452   PMID:17168834   PMID:17251582   PMID:17267505   PMID:17289077   PMID:17317667   PMID:17341462   PMID:17352406   PMID:17452463  
PMID:17461970   PMID:17502349   PMID:17537237   PMID:17540406   PMID:17625008   PMID:17643375   PMID:17661632   PMID:17686863   PMID:17690245   PMID:17700062   PMID:17724342   PMID:17855633  
PMID:17907378   PMID:18029348   PMID:18039861   PMID:18187620   PMID:18200011   PMID:18205180   PMID:18281698   PMID:18353948   PMID:18391197   PMID:18483487   PMID:18566585   PMID:18620576  
PMID:18655042   PMID:18773076   PMID:18780834   PMID:18931076   PMID:18976462   PMID:18976975   PMID:18991615   PMID:19020832   PMID:19139066   PMID:19179338   PMID:19208825   PMID:19211771  
PMID:19223581   PMID:19275586   PMID:19275730   PMID:19297489   PMID:19387490   PMID:19435492   PMID:19454010   PMID:19575011   PMID:19716452   PMID:19812265   PMID:19818711   PMID:19883659  
PMID:19914168   PMID:19956800   PMID:20018238   PMID:20054825   PMID:20064163   PMID:20081228   PMID:20153263   PMID:20210365   PMID:20227660   PMID:20305087   PMID:20385237   PMID:20385240  
PMID:20431927   PMID:20471948   PMID:20471949   PMID:20535204   PMID:20551309   PMID:20562857   PMID:20571604   PMID:20618343   PMID:20670891   PMID:20683478   PMID:20714219   PMID:20724442  
PMID:20808803   PMID:20811636   PMID:20828615   PMID:20854876   PMID:20943989   PMID:20976203   PMID:21030982   PMID:21035463   PMID:21204735   PMID:21220424   PMID:21360054   PMID:21450947  
PMID:21533037   PMID:21555454   PMID:21555514   PMID:21697490   PMID:21709748   PMID:21729782   PMID:21763494   PMID:21763496   PMID:21873635   PMID:21951552   PMID:22094252   PMID:22100159  
PMID:22190034   PMID:22205749   PMID:22211660   PMID:22229121   PMID:22253435   PMID:22323290   PMID:22342181   PMID:22355797   PMID:22421880   PMID:22422068   PMID:22483617   PMID:22567366  
PMID:22569018   PMID:22591364   PMID:22592529   PMID:22692005   PMID:22771113   PMID:22939629   PMID:22959624   PMID:22990118   PMID:23007159   PMID:23064645   PMID:23087374   PMID:23092279  
PMID:23110726   PMID:23152527   PMID:23170164   PMID:23247501   PMID:23251033   PMID:23274668   PMID:23296566   PMID:23330719   PMID:23455922   PMID:23471103   PMID:23518577   PMID:23539624  
PMID:23569210   PMID:23602568   PMID:23658523   PMID:23667531   PMID:23678366   PMID:23691059   PMID:23754689   PMID:23827503   PMID:23977272   PMID:24158816   PMID:24204263   PMID:24217245  
PMID:24316072   PMID:24351800   PMID:24359561   PMID:24360279   PMID:24367103   PMID:24515107   PMID:24565118   PMID:24727379   PMID:24793763   PMID:24981860   PMID:24985203   PMID:24985467  
PMID:25116364   PMID:25132562   PMID:25187353   PMID:25496916   PMID:25653431   PMID:25731772   PMID:25735922   PMID:25781978   PMID:25909811   PMID:25921289   PMID:26186194   PMID:26188041  
PMID:26344197   PMID:26350902   PMID:26496610   PMID:26659056   PMID:26725010   PMID:26760575   PMID:26949251   PMID:26972000   PMID:27193293   PMID:27365398   PMID:27545878   PMID:27684187  
PMID:27731797   PMID:28345603   PMID:28422315   PMID:28431135   PMID:28514442   PMID:28533407   PMID:28555140   PMID:29180619   PMID:29229926   PMID:29467282   PMID:29507755   PMID:29509190  
PMID:29615496   PMID:29791506   PMID:29802200   PMID:29845934   PMID:29884807   PMID:30415952   PMID:30463901   PMID:30585729   PMID:30649429   PMID:30782840   PMID:30786885   PMID:30890647  
PMID:31048545   PMID:31091453   PMID:31239290   PMID:31527615   PMID:31586073   PMID:31603123   PMID:31753913   PMID:32129710   PMID:32152128   PMID:32203420   PMID:32416067  


Genomics

Comparative Map Data
CCNT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1248,688,458 - 48,716,998 (-)EnsemblGRCh38hg38GRCh38
GRCh381248,688,458 - 48,716,707 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371249,082,241 - 49,110,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361247,373,019 - 47,397,048 (-)NCBINCBI36hg18NCBI36
Build 341247,373,018 - 47,397,048NCBI
Celera1247,882,748 - 47,906,759 (-)NCBI
Cytogenetic Map12q13.11-q13.12NCBI
HuRef1246,116,314 - 46,144,840 (-)NCBIHuRef
CHM1_11249,048,056 - 49,076,621 (-)NCBICHM1_1
Ccnt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391598,436,570 - 98,468,340 (-)NCBIGRCm39mm39
GRCm39 Ensembl1598,436,570 - 98,468,804 (-)Ensembl
GRCm381598,538,690 - 98,567,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1598,538,689 - 98,570,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv371598,373,642 - 98,398,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv361598,371,245 - 98,395,670 (-)NCBImm8
Celera15100,690,667 - 100,714,825 (-)NCBICelera
Cytogenetic Map15F1NCBI
Ccnt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27129,687,146 - 129,718,082 (-)NCBI
Rnor_6.0 Ensembl7140,219,551 - 140,245,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07140,215,052 - 140,245,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X114,723,098 - 114,752,376 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47137,288,635 - 137,314,809 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17137,365,064 - 137,391,433 (-)NCBI
Celera7126,182,570 - 126,208,635 (-)NCBICelera
Cytogenetic Map7q36NCBI
Ccnt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555007,580,625 - 7,606,913 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555007,580,625 - 7,606,913 (-)NCBIChiLan1.0ChiLan1.0
CCNT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11240,906,907 - 40,935,392 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1240,906,907 - 40,935,392 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01240,028,334 - 40,057,393 (+)NCBIMhudiblu_PPA_v0panPan3
CCNT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1275,788,426 - 5,817,518 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl275,788,785 - 5,817,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2740,440,318 - 40,469,408 (-)NCBI
ROS_Cfam_1.0275,839,609 - 5,868,796 (+)NCBI
UMICH_Zoey_3.1275,803,121 - 5,832,059 (+)NCBI
UNSW_CanFamBas_1.0275,793,437 - 5,822,569 (+)NCBI
UU_Cfam_GSD_1.02740,832,282 - 40,861,450 (-)NCBI
Ccnt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494566,576,723 - 66,597,193 (+)NCBI
SpeTri2.0NW_0049365126,567,663 - 6,588,107 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl514,768,429 - 14,816,613 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1514,768,423 - 14,808,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2515,062,983 - 15,101,607 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11144,932,774 - 44,966,412 (-)NCBI
ChlSab1.1 Ensembl1144,937,350 - 44,966,018 (-)Ensembl
Ccnt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248163,396,740 - 3,445,976 (+)NCBI

Position Markers
RH104016  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,090,492 - 49,090,597UniSTSGRCh37
Build 361247,376,759 - 47,376,864RGDNCBI36
Celera1247,886,488 - 47,886,593RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,124,565 - 46,124,670UniSTS
GeneMap99-GB4 RH Map12215.68UniSTS
SHGC-153516  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,109,725 - 49,110,037UniSTSGRCh37
Build 361247,395,992 - 47,396,304RGDNCBI36
Celera1247,905,703 - 47,906,015RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,143,784 - 46,144,096UniSTS
TNG Radiation Hybrid Map1222299.0UniSTS
PMC136632P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,087,174 - 49,088,030UniSTSGRCh37
Build 361247,373,441 - 47,374,297RGDNCBI36
Celera1247,883,170 - 47,884,026RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,121,248 - 46,122,104UniSTS
PMC153984P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,086,815 - 49,087,761UniSTSGRCh37
Build 361247,373,082 - 47,374,028RGDNCBI36
Celera1247,882,811 - 47,883,757RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,120,889 - 46,121,835UniSTS
CCNT1_2415  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,086,688 - 49,087,517UniSTSGRCh37
Build 361247,372,955 - 47,373,784RGDNCBI36
Celera1247,882,684 - 47,883,513RGD
HuRef1246,120,762 - 46,121,591UniSTS
RH17417  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,082,380 - 49,082,571UniSTSGRCh37
Build 361247,368,647 - 47,368,838RGDNCBI36
Celera1247,878,375 - 47,878,566RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,116,453 - 46,116,644UniSTS
GeneMap99-GB4 RH Map12215.73UniSTS
NCBI RH Map12391.9UniSTS
RH44408  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,082,709 - 49,082,874UniSTSGRCh37
Build 361247,368,976 - 47,369,141RGDNCBI36
Celera1247,878,705 - 47,878,870RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,116,783 - 46,116,948UniSTS
GeneMap99-GB4 RH Map12216.5UniSTS
STS-H84164  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,082,286 - 49,082,466UniSTSGRCh37
Build 361247,368,553 - 47,368,733RGDNCBI36
Celera1247,878,281 - 47,878,461RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,116,359 - 46,116,539UniSTS
GeneMap99-GB4 RH Map12215.68UniSTS
NCBI RH Map12391.9UniSTS
SHGC-33565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,087,567 - 49,087,691UniSTSGRCh37
Build 361247,373,834 - 47,373,958RGDNCBI36
Celera1247,883,563 - 47,883,687RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,121,641 - 46,121,765UniSTS
TNG Radiation Hybrid Map1222254.0UniSTS
GeneMap99-GB4 RH Map12215.68UniSTS
Whitehead-RH Map12295.9UniSTS
NCBI RH Map12391.9UniSTS
GeneMap99-G3 RH Map121895.0UniSTS
RH70421  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,087,616 - 49,087,880UniSTSGRCh37
Build 361247,373,883 - 47,374,147RGDNCBI36
Celera1247,883,612 - 47,883,876RGD
Cytogenetic Map12q13.11UniSTS
HuRef1246,121,690 - 46,121,954UniSTS
GeneMap99-GB4 RH Map12213.76UniSTS
NCBI RH Map12391.9UniSTS
CCNT1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371249,088,004 - 49,088,217UniSTSGRCh37
Celera1247,884,000 - 47,884,213UniSTS
HuRef1246,122,078 - 46,122,291UniSTS


Related Rat Strains
The following Strains have been annotated to CCNT1

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR27Bhsa-miR-27b-3pMirtarbaseexternal_infoFlow//Luciferase reporter assay//Microarray//qRT-PFunctional MTI22205749
MIR198hsa-miR-198Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19148268

Predicted Target Of
Summary Value
Count of predictions:2456
Count of miRNA genes:1148
Interacting mature miRNAs:1435
Transcripts:ENST00000261900, ENST00000417344, ENST00000550457, ENST00000551989
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1725 1353 1235 188 1213 114 3584 963 1271 239 1348 1571 88 1119 2084 4
Low 713 1633 491 436 732 351 773 1233 2460 180 112 42 86 1 85 704 1 2
Below cutoff 1 5 6 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001277842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC079951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF045161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF048730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL832083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX098766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF688064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY016640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY966264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261900   ⟹   ENSP00000261900
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,688,458 - 48,716,707 (-)Ensembl
RefSeq Acc Id: ENST00000417344   ⟹   ENSP00000399845
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,693,033 - 48,716,675 (-)Ensembl
RefSeq Acc Id: ENST00000550457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,705,624 - 48,714,520 (-)Ensembl
RefSeq Acc Id: ENST00000551989
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,693,930 - 48,695,977 (-)Ensembl
RefSeq Acc Id: ENST00000618666   ⟹   ENSP00000481035
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,688,458 - 48,716,998 (-)Ensembl
RefSeq Acc Id: ENST00000640148   ⟹   ENSP00000491861
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1248,697,953 - 48,716,719 (-)Ensembl
RefSeq Acc Id: NM_001240   ⟹   NP_001231
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,688,458 - 48,716,707 (-)NCBI
GRCh371249,082,241 - 49,110,781 (-)NCBI
Build 361247,373,019 - 47,397,048 (-)NCBI Archive
HuRef1246,116,314 - 46,144,840 (-)NCBI
CHM1_11249,048,056 - 49,076,621 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001277842   ⟹   NP_001264771
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,688,458 - 48,716,707 (-)NCBI
GRCh371249,082,241 - 49,110,781 (-)NCBI
HuRef1246,116,314 - 46,144,840 (-)NCBI
CHM1_11249,048,056 - 49,076,621 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020197   ⟹   XP_016875686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,688,458 - 48,712,323 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001231   ⟸   NM_001240
- Peptide Label: isoform a
- UniProtKB: O60563 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264771   ⟸   NM_001277842
- Peptide Label: isoform b
- UniProtKB: O60563 (UniProtKB/Swiss-Prot),   A8K4M5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016875686   ⟸   XM_017020197
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000399845   ⟸   ENST00000417344
RefSeq Acc Id: ENSP00000491861   ⟸   ENST00000640148
RefSeq Acc Id: ENSP00000261900   ⟸   ENST00000261900
RefSeq Acc Id: ENSP00000481035   ⟸   ENST00000618666
Protein Domains
CYCLIN

Promoters
RGD ID:6789782
Promoter ID:HG_KWN:15515
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001240,   UC009ZKZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361247,396,751 - 47,397,707 (-)MPROMDB
RGD ID:7223749
Promoter ID:EPDNEW_H17620
Type:initiation region
Name:CCNT1_1
Description:cyclin T1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17621  EPDNEW_H17622  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,716,707 - 48,716,767EPDNEW
RGD ID:7223751
Promoter ID:EPDNEW_H17621
Type:initiation region
Name:CCNT1_3
Description:cyclin T1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17620  EPDNEW_H17622  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,716,836 - 48,716,896EPDNEW
RGD ID:7223753
Promoter ID:EPDNEW_H17622
Type:initiation region
Name:CCNT1_2
Description:cyclin T1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17620  EPDNEW_H17621  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381248,717,056 - 48,717,116EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001240.3(CCNT1):c.1998C>T (p.Ser666=) single nucleotide variant Malignant melanoma [RCV000062512] Chr12:48693216 [GRCh38]
Chr12:49086999 [GRCh37]
Chr12:47373266 [NCBI36]
Chr12:12q13.11
not provided
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12p11.21-q13.12(chr12:31886971-50360461)x3 copy number gain See cases [RCV000207454] Chr12:31886971..50360461 [GRCh37]
Chr12:12p11.21-q13.12
pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:48961450-49255821)x3 copy number gain See cases [RCV000448103] Chr12:48961450..49255821 [GRCh37]
Chr12:12q13.11-13.12
uncertain significance
GRCh37/hg19 12q11-13.12(chr12:37857750-49791459)x3 copy number gain See cases [RCV000448835] Chr12:37857750..49791459 [GRCh37]
Chr12:12q11-13.12
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NC_000012.11:g.26370251_54361538inv inversion not specified [RCV000714265] Chr12:26370251..54361538 [GRCh37]
Chr12:12p12.1-q13.13
uncertain significance
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:49055179-49466566)x3 copy number gain not provided [RCV000750395] Chr12:49055179..49466566 [GRCh37]
Chr12:12q13.11-13.12
benign
GRCh37/hg19 12q13.11-13.12(chr12:48944713-49265377)x3 copy number gain not provided [RCV000849162] Chr12:48944713..49265377 [GRCh37]
Chr12:12q13.11-13.12
uncertain significance
GRCh37/hg19 12q13.11-13.12(chr12:49034325-49468966)x1 copy number loss Kabuki syndrome 1 [RCV000859976] Chr12:49034325..49468966 [GRCh37]
Chr12:12q13.11-13.12
pathogenic
GRCh37/hg19 12q13.11-13.12(chr12:49024019-50299974)x3 copy number gain not provided [RCV001259140] Chr12:49024019..50299974 [GRCh37]
Chr12:12q13.11-13.12
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1599 AgrOrtholog
COSMIC CCNT1 COSMIC
Ensembl Genes ENSG00000129315 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000261900 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000399845 UniProtKB/Swiss-Prot
  ENSP00000481035 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000491861 UniProtKB/TrEMBL
Ensembl Transcript ENST00000261900 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000417344 UniProtKB/Swiss-Prot
  ENST00000618666 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000640148 UniProtKB/TrEMBL
GTEx ENSG00000129315 GTEx
HGNC ID HGNC:1599 ENTREZGENE
Human Proteome Map CCNT1 Human Proteome Map
InterPro CCNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin/Ssn8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:904 UniProtKB/Swiss-Prot
NCBI Gene 904 ENTREZGENE
OMIM 143055 OMIM
PANTHER PTHR10026 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10026:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Cyclin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26163 PharmGKB
SMART CYCLIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2PQ16_HUMAN UniProtKB/TrEMBL
  A8K4M5 ENTREZGENE, UniProtKB/TrEMBL
  CCNT1_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A9XU13 UniProtKB/Swiss-Prot
  E7EX76 UniProtKB/Swiss-Prot
  O60581 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 CCNT1  cyclin T1  HIVE1  human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1  Data Merged 737654 PROVISIONAL
2011-08-16 CCNT1  cyclin T1  CCNT1  cyclin T1  Symbol and/or name change 5135510 APPROVED