| 1347618 | CAPZB | capping actin protein of muscle Z-line subunit beta | This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions i n regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013] | 1 | 19338775 | 19485539 | Human | 153 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1359099 | Capzb | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH dementia; Spinal Cord Injuries; Acute Coronary Syndrome (ortholog); FOUND IN dendritic spine; neuronal cell body; brush border (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil | 5 | 156718619 | 156818623 | Rat | 152 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1549975 | Capzb | capping actin protein of muscle Z-line subunit beta | This gene encodes the beta subunit of a highly conserved filamentous actin capping protein that binds the barbed end of filamentous actin to stabilize it and terminate elongation. Interaction of this protein with the barbed end of the actin filament occurs through binding of the amphipathic helix at the C-terminus to the hydrophobic cleft on the actin molecule. This gene is required for a variety of dynamic actin-mediated processes including organization of lamellipodia and filopodia, growth cone morphology and neurite outgrowth in hippocampal neurons, and asymmetric spindle migration and polar body extrusion during oocyte maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] | 4 | 138920210 | 139019131 | Mouse | 173 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8709267 | Capzb | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN brush border (ortholog); cortical cytoskeleton (ortholog); dendritic spine (ortholog) | NW_004955452 | 34454 | 168514 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11823337 | CAPZB | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndro me (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN dendritic spine (ortholog); dynactin complex (ortholog); intercalated disc (ortholog) | 1 | 18297434 | 18444011 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12157546 | CAPZB | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndro me (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN dendritic spine (ortholog); dynactin complex (ortholog); intercalated disc (ortholog) | 2 | 79182668 | 79311529 | Dog | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12486060 | Capzb | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndro me (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN dendritic spine (ortholog); dynactin complex (ortholog); intercalated disc (ortholog) | NW_004936474 | 5594193 | 5656665 | Squirrel | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930559 | Capzb | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndro me (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN brush border (ortholog); cortical cytoskeleton (ortholog); dendritic spine (ortholog) | | | | Naked Mole-Rat | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14066338 | CAPZB | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN microtubule-based process; actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN dendritic spine (ortholog); intercalated disc (ortholog); neuronal cell body (ortholog) | | | | Pig | 67 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 625871627 | Capzb | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN brush border (ortholog); cortical cytoskeleton (ortholog); dendritic spine (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284611269 | capzb | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18590561 | CAPZB | capping actin protein of muscle Z-line subunit beta | ENCODES a protein that exhibits actin filament binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN actin polymerization or depolymerization (ortholog); activation of protein kinase C activity (ortholog); barbed-end actin filament capping (ortholog); ASSOCIATED WITH Acute Coronary Syndro me (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN dendritic spine (ortholog); dynactin complex (ortholog); intercalated disc (ortholog) | | | | Green Monkey | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287787463 | capzb.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329329152 | capzb.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 15090884 | CAPZBP1 | CAPZB pseudogene 1 | | 2 | 103623554 | 103623848 | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 16555117 | AC018880.2 | capping protein (actin filament) muscle Z-line, beta (CAPZB) pseudogene | | | | | Human | | name | gene, processed_pseudogene |