| 2270 | Capns1 | calpain, small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity; protein-containing complex binding; INVOLVED IN protein catabolic process; proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 1 | 94572083 | 94582332 | Rat | 141 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 735486 | CAPNS1 | calpain small subunit 1 | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Cal pain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] | 19 | 36140066 | 36150353 | Human | 162 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 735487 | Capns1 | calpain, small subunit 1 | Enables calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in protein catabolic process. Predicted to be located in cytosol and membrane. Predicted to be part of calpain complex. Is expressed in medulla oblongata basal plate mantle layer; nucleus pulposus; pons mantle l ayer; and ventral grey horn. Orthologous to human CAPNS1 (calpain small subunit 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 29886359 | 29898308 | Mouse | 157 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8994935 | Capns1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog) | NW_004955468 | 2446631 | 2454369 | Chinchilla | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11962509 | CAPNS1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN calpain complex (inferred); cytoplasm (inferred); cytosol (inferred) | 19 | 33059291 | 33069311 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12276868 | CAPNS1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred) | 1 | 116549608 | 116558928 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12447155 | Capns1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN calpain complex (inferred); cytoplasm (inferred); cytosol (inferred) | NW_004936922 | 151791 | 161655 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625995171 | Capns1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog) | | | | Black Rat | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14292838 | CAPNS1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity; protein-containing complex binding (ortholog); INVOLVED IN proteolysis; protein catabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog); Prostatic Neoplasms (ortholog); FOUND IN cytoplasm; INTERACTS WITH bis(2-chloroethyl) sulfide | | | | Pig | 30 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18927748 | Capns1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN cytosol (ortholog); membrane (ortholog) | | | | Naked Mole-Rat | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287509153 | capns1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18735830 | CAPNS1 | calpain small subunit 1 | ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH COVID-19 (ortholog); primary pulmonary hypertension 6 (ortholog) ; Prostatic Neoplasms (ortholog); FOUND IN calpain complex (inferred); cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287508583 | capns1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934253 | capns1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 287596619 | capns1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935029 | capns1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596935596 | capns1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934678 | capns1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16565660 | AD001527.1 | novel transcript, antisense to CAPNS1 | | | | | Human | | name | gene, lncrna |
| 5128765 | CAPNS1P1 | calpain small subunit 1 pseudogene 1 | | 1 | 89394021 | 89394660 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
