CAPNS1 (calpain small subunit 1) - Rat Genome Database

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Gene: CAPNS1 (calpain small subunit 1) Pan paniscus
Analyze
Symbol: CAPNS1
Name: calpain small subunit 1
RGD ID: 11962509
Description: ENCODES a protein that exhibits calcium-dependent cysteine-type endopeptidase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN protein catabolic process (ortholog); proteolysis (ortholog); ASSOCIATED WITH Brugada syndrome 5 (ortholog); COVID-19 (ortholog); genetic disease (ortholog); FOUND IN calpain complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,142,012 - 42,152,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,125,513 - 44,135,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,059,291 - 33,069,311 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,806,746 - 41,816,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,806,746 - 41,816,858 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
calpain complex  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IEA)
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CAPNS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,142,012 - 42,152,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,125,513 - 44,135,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,059,291 - 33,069,311 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,806,746 - 41,816,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,806,746 - 41,816,858 (+)Ensemblpanpan1.1panPan2
CAPNS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,140,066 - 36,150,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,139,953 - 36,150,353 (+)EnsemblGRCh38hg38GRCh38
GRCh371936,630,968 - 36,641,255 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,322,758 - 41,333,095 (+)NCBINCBI36Build 36hg18NCBI36
Build 341941,322,757 - 41,333,094NCBI
Celera1933,345,090 - 33,355,427 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,136,390 - 33,146,727 (+)NCBIHuRef
CHM1_11936,632,259 - 36,643,261 (+)NCBICHM1_1
T2T-CHM13v2.01938,685,882 - 38,696,171 (+)NCBIT2T-CHM13v2.0
Capns1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,886,359 - 29,898,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,886,361 - 29,898,236 (-)EnsemblGRCm39 Ensembl
GRCm38730,186,934 - 30,198,883 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,186,936 - 30,198,811 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,971,961 - 30,980,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,895,708 - 29,903,784 (-)NCBIMGSCv36mm8
Celera724,783,745 - 24,791,616 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.31NCBI
Capns1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,572,083 - 94,582,332 (-)NCBIGRCr8
mRatBN7.2185,444,613 - 85,454,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,444,608 - 85,454,795 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx190,861,573 - 90,871,706 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,325,245 - 99,335,358 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,619,837 - 92,629,970 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0191,058,528 - 91,064,880 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,652,446 - 88,657,845 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,652,446 - 88,657,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0192,056,305 - 92,207,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,519,568 - 85,525,929 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,820,845 - 79,830,375 (-)NCBICelera
Cytogenetic Map1q21NCBI
Capns1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,447,111 - 2,452,982 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554682,446,631 - 2,454,369 (-)NCBIChiLan1.0ChiLan1.0
CAPNS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,549,608 - 116,558,928 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,550,000 - 116,558,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,955,616 - 115,964,853 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,151,011 - 117,160,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,151,015 - 117,159,238 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,720,393 - 116,729,644 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,340,642 - 116,349,899 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,393,688 - 117,402,927 (-)NCBIUU_Cfam_GSD_1.0
Capns1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,381,612 - 11,391,526 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936922151,599 - 164,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936922151,791 - 161,655 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPNS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,511,295 - 45,518,610 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,511,410 - 45,518,610 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,913,605 - 40,920,805 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CAPNS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1631,049,509 - 31,061,219 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl631,050,494 - 31,061,421 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660738,849,775 - 8,861,494 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Capns1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479410,382,157 - 10,390,768 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000055014   ⟹   ENSPPAP00000032148
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,806,746 - 41,816,507 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055023   ⟹   ENSPPAP00000032157
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,806,746 - 41,816,507 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055031   ⟹   ENSPPAP00000032165
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,807,832 - 41,816,858 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055032   ⟹   ENSPPAP00000032166
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,807,832 - 41,816,858 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055041   ⟹   ENSPPAP00000032175
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1941,807,832 - 41,815,993 (+)Ensembl
RefSeq Acc Id: XM_003816113   ⟹   XP_003816161
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22042,142,036 - 42,152,045 (+)NCBI
NHGRI_mPanPan11944,125,580 - 44,135,599 (+)NCBI
Mhudiblu_PPA_v01933,059,307 - 33,069,311 (+)NCBI
PanPan1.11941,806,746 - 41,816,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008969121   ⟹   XP_008967369
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22042,142,013 - 42,152,045 (+)NCBI
NHGRI_mPanPan11944,125,514 - 44,135,599 (+)NCBI
Mhudiblu_PPA_v01933,059,291 - 33,069,311 (+)NCBI
PanPan1.11941,806,746 - 41,816,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008969122   ⟹   XP_008967370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22042,142,012 - 42,152,045 (+)NCBI
NHGRI_mPanPan11944,125,513 - 44,135,599 (+)NCBI
Mhudiblu_PPA_v01933,059,291 - 33,069,311 (+)NCBI
PanPan1.11941,806,777 - 41,816,507 (+)NCBI
Sequence:
RefSeq Acc Id: XM_057300538   ⟹   XP_057156521
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22042,142,035 - 42,152,045 (+)NCBI
NHGRI_mPanPan11944,125,580 - 44,135,599 (+)NCBI
RefSeq Acc Id: XP_008967369   ⟸   XM_008969121
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BR52 (UniProtKB/TrEMBL),   A0A2R9BUP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003816161   ⟸   XM_003816113
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BR55 (UniProtKB/TrEMBL),   A0A2R9BUP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008967370   ⟸   XM_008969122
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BR52 (UniProtKB/TrEMBL),   A0A2R9BUP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000032148   ⟸   ENSPPAT00000055014
RefSeq Acc Id: ENSPPAP00000032157   ⟸   ENSPPAT00000055023
RefSeq Acc Id: ENSPPAP00000032165   ⟸   ENSPPAT00000055031
RefSeq Acc Id: ENSPPAP00000032166   ⟸   ENSPPAT00000055032
RefSeq Acc Id: ENSPPAP00000032175   ⟸   ENSPPAT00000055041
RefSeq Acc Id: XP_057156521   ⟸   XM_057300538
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BR55 (UniProtKB/TrEMBL)
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000038912 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000055014.1 UniProtKB/TrEMBL
  ENSPPAT00000055023.1 UniProtKB/TrEMBL
  ENSPPAT00000055031.1 UniProtKB/TrEMBL
  ENSPPAT00000055032.1 UniProtKB/TrEMBL
  ENSPPAT00000055041.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
KEGG Report pps:100987448 UniProtKB/TrEMBL
NCBI Gene CAPNS1 ENTREZGENE
PANTHER CALPAIN, SMALL SUBUNIT 1 A-RELATED UniProtKB/TrEMBL
  CALPAIN, SMALL SUBUNIT 1 A-RELATED UniProtKB/TrEMBL
  PTHR46735:SF1 UniProtKB/TrEMBL
Pfam EF-hand_8 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A2R9BR52 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BR55 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BRV4_PANPA UniProtKB/TrEMBL
  A0A2R9BUP0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BUP9_PANPA UniProtKB/TrEMBL