| 2266 | Canx | calnexin | ENCODES a protein that exhibits apolipoprotein binding; ionotropic glutamate receptor binding; INVOLVED IN clathrin-dependent endocytosis (ortholog); synaptic vesicle endocytosis (ortholog); PARTICIPATES IN antigen processing and presentation pathway; Endoplasmic Reticulum-associated degradation pat hway; phagocytosis pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon; dendrite cytoplasm; dendritic spine; INTERACTS WITH (R,R,R)-alpha-tocopherol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 10 | 35124941 | 35157954 | Rat | 260 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 737068 | CANX | calnexin | This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a c entral role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018] | 5 | 179678656 | 179731641 | Human | 275 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 737069 | Canx | calnexin | Predicted to enable apolipoprotein binding activity; calcium ion binding activity; and ionotropic glutamate receptor binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in endoplasmic reticulum quality control compartment and nuclear membrane. Is ex pressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; intestine; and musculature. Orthologous to human CANX (calnexin). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 50184784 | 50216500 | Mouse | 296 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8783345 | Canx | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); synaptic vesicle endocytosis (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | NW_004955408 | 850773 | 894362 | Chinchilla | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11800596 | CANX | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (inferred); ERAD pathway (inferred); protein folding (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardi al Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | 5 | 174832964 | 174884804 | Bonobo | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12342540 | CANX | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); synaptic vesicle endocytosis (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog); INTERACTS WITH bisphenol A | 11 | 1966612 | 1998620 | Dog | 54 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12442908 | Canx | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (inferred); ERAD pathway (inferred); protein folding (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardi al Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | NW_004936739 | 1051853 | 1085658 | Squirrel | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18935652 | Canx | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); synaptic vesicle endocytosis (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18739999 | CANX | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (inferred); ERAD pathway (inferred); protein folding (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardi al Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | | | | Green Monkey | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626135948 | Canx | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (ortholog); synaptic vesicle endocytosis (ortholog); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | | | | Black Rat | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241024 | canx | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13890059 | CANX | calnexin | ENCODES a protein that exhibits apolipoprotein binding (ortholog); ionotropic glutamate receptor binding (ortholog); INVOLVED IN clathrin-dependent endocytosis (inferred); protein folding (inferred); synaptic vesicle endocytosis (inferred); ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ort holog); Myocardial Ischemia (ortholog); obesity (ortholog); FOUND IN axon (ortholog); dendrite cytoplasm (ortholog); dendritic spine (ortholog) | | | | Pig | 82 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 155251105 | canx.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241023 | canx.S | | | | | | African Clawed Frog | | symbol | gene, null |