| 68385 | Cacnb4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding; voltage-gated calcium channel activity; calcium channel regulator activity (ortholog); INVOLVED IN calcium ion transport; negative regulation of cell population proliferation; negative regulation of G1/S transition of mitotic cell cycle; PARTIC IPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck; presynapse; glutamatergic synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil | 3 | 57315900 | 57578271 | Rat | 178 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 68558 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 | This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. V arious versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE), juvenile myoclonic epilepsy (JME), and episodic ataxia, type 5. [provided by RefSeq, Aug 2016] | 2 | 151832771 | 152099167 | Human | 352 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 68559 | Cacnb4 | calcium channel, voltage-dependent, beta 4 subunit | Enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including adult walking behavior; cellular response to leukemia inhibitory factor; and h ematopoietic or lymphoid organ development. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is expressed in brain; heart; spinal cord; and urinary system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and generalized epilepsy. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Jul 2025] | 2 | 52318332 | 52566816 | Mouse | 251 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9018540 | Cacnb4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transmembrane transport (ortholog); calcium ion transport (ortholog); PARTIC IPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN glutamatergic synapse (ortholog); nuclear speck (ortholog); plasma membrane (ortholog) | NW_004955440 | 17364996 | 17497446 | Chinchilla | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11979703 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediate d signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); plasma membrane (ortholog); presynapse (ortholog) | 2B | 39137777 | 39399007 | Bonobo | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12494904 | Cacnb4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediate d signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); plasma membrane (ortholog); presynapse (ortholog) | NW_004936469 | 25494820 | 25745783 | Squirrel | 66 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 43583432 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediate d signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); plasma membrane (ortholog); presynapse (ortholog) | 19 | 52987170 | 53116410 | Dog | 69 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254023 | cacnb4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626052684 | Cacnb4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transmembrane transport (ortholog); calcium ion transport (ortholog); PARTIC IPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN glutamatergic synapse (ortholog); nuclear speck (ortholog); plasma membrane (ortholog) | | | | Black Rat | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18452562 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediate d signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); plasma membrane (ortholog); presynapse (ortholog) | | | | Green Monkey | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18921146 | Cacnb4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits calcium channel regulator activity (ortholog); protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN cal cium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN glutamatergic synapse (ortholog); nuclear speck (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14264112 | CACNB4 | calcium voltage-gated channel auxiliary subunit beta 4 | ENCODES a protein that exhibits protein kinase binding (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); calcium ion transport (ortholog); cAMP metabolic process (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediate d signaling pathway; ASSOCIATED WITH Ataxia (ortholog); dilated cardiomyopathy (ortholog); epilepsy (ortholog); FOUND IN nuclear speck (ortholog); plasma membrane (ortholog); presynapse (ortholog) | | | | Pig | 69 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 626183011 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857543 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858306 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405858085 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626181744 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405859583 | cacnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856214 | cacnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865463 | cacnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865276 | cacnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865343 | cacnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626172048 | cacnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |