Blnk Gene Search Result

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17 records found for search term Blnk

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1347273	BLNK	B cell linker	This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine resid ... (more) ues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]	10	96189171	96271569	Human	243	symbol , COSMIC , Human Proteome Map , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
1558103	Blnk	B cell linker	Predicted to enable several functions, including SH2 domain binding activity; enzyme binding activity; and molecular condensate scaffold activity. Involved in positive regulation of gene expression. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; immune ... (more) system; liver; and olfactory epithelium. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker). [provided by Alliance of Genome Resources, Jul 2025]	19	40917371	40982664	Mouse	284	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1561933	Blnk	B-cell linker	ENCODES a protein that exhibits enzyme binding (ortholog); lipid binding (ortholog); molecular condensate scaffold activity (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); intracellular signal transduction (ortholog); positive regulation of gene expression (ortholog); PARTICIPA ... (more) TES IN phosphatidylinositol 3-kinase class I signaling pathway; B cell receptor signaling pathway; primary immunodeficiency pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; aflatoxin B1	1	249703064	249770533	Rat	176	symbol , PhenoGen	gene, protein-coding, PROVISIONAL [RefSeq]
8752519	Blnk	B cell linker	ENCODES a protein that exhibits enzyme binding (ortholog); lipid binding (ortholog); molecular condensate scaffold activity (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); intracellular signal transduction (ortholog); positive regulation of gene expression (ortholog); PARTICIPA ... (more) TES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog)	NW_004955507	2398694	2466461	Chinchilla	35	symbol	gene, protein-coding, MODEL [RefSeq]
11924819	BLNK	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); intracellular signal transduct ... (more) ion (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)	10	92803408	92936868	Bonobo	37	symbol	gene, protein-coding, MODEL [RefSeq]
12114566	BLNK	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); intracellular signal transduction (inferred); positive regulation of gene expression (inferred); PARTICIPA ... (more) TES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)	28	9622438	9700335	Dog	39	symbol	gene, protein-coding, MODEL [RefSeq]
12464470	Blnk	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); intracellular signal transduct ... (more) ion (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)	NW_004936636	3220554	3290054	Squirrel	37	symbol	gene, protein-coding, MODEL [RefSeq]
18936439	Blnk	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); intracellular signal transduct ... (more) ion (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)				Naked Mole-Rat	37	symbol	gene, protein-coding, MODEL [RefSeq]
13928582	BLNK	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); intracellular signal transduction (inferred); positive regulation of gene expression (inferred); PARTICIPA ... (more) TES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)				Pig	39	symbol	gene, protein-coding, MODEL [RefSeq]
18370835	BLNK	B cell linker	ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); intracellular signal transduct ... (more) ion (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); membrane (inferred)				Green Monkey	37	symbol	gene, protein-coding, MODEL [RefSeq]
152178083	BLNK	B cell linker					Naked Mole-Rat		symbol	gene, protein-coding
155250358	blnk						Tropical Clawed Frog		symbol	gene, null
626079140	Blnk	B cell linker	ENCODES a protein that exhibits enzyme binding (ortholog); lipid binding (ortholog); molecular condensate scaffold activity (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); intracellular signal transduction (ortholog); positive regulation of gene expression (ortholog); PARTICIPA ... (more) TES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); membrane (ortholog)				Black Rat	35	symbol	gene, protein-coding, MODEL [RefSeq]
155259632	blnk.L						African Clawed Frog		symbol	gene, null
155250357	blnk.S						African Clawed Frog		symbol	gene, null
1606407	SH2D6	SH2 domain containing 6	Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and intracellular signal transduction. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]	2	85418714	85437029	Human	26	old_gene_name	gene, protein-coding, VALIDATED [RefSeq]
1605010	CLNK	cytokine dependent hematopoietic cell linker	MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 ... (more) (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]	4	10486395	10734846	Human	43	description	gene, protein-coding, VALIDATED [RefSeq]