BLNK (B cell linker) - Rat Genome Database

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Gene: BLNK (B cell linker) Pan paniscus
Analyze
Symbol: BLNK
Name: B cell linker
RGD ID: 11924819
Description: ENCODES a protein that exhibits enzyme binding (inferred); lipid binding (inferred); molecular condensate scaffold activity (inferred); INVOLVED IN B cell receptor signaling pathway (inferred); cell surface receptor protein tyrosine kinase signaling pathway (inferred); intracellular signal transduction (inferred); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); agammaglobulinemia 4 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: B-cell linker
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,096,234 - 108,231,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,101,552 - 108,236,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01092,803,408 - 92,936,868 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,310,764 - 96,391,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1096,316,103 - 96,391,067 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
BLNK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28108,096,234 - 108,231,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110108,101,552 - 108,236,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01092,803,408 - 92,936,868 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11096,310,764 - 96,391,067 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1096,316,103 - 96,391,067 (-)Ensemblpanpan1.1panPan2
BLNK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381096,189,171 - 96,271,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1096,189,171 - 96,271,587 (-)EnsemblGRCh38hg38GRCh38
GRCh371097,948,927 - 98,031,326 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361097,941,445 - 98,021,316 (-)NCBINCBI36Build 36hg18NCBI36
Build 341097,941,446 - 98,021,316NCBI
Celera1091,692,656 - 91,772,534 (-)NCBICelera
Cytogenetic Map10q24.1NCBI
HuRef1091,579,452 - 91,659,253 (-)NCBIHuRef
CHM1_11098,233,338 - 98,313,206 (-)NCBICHM1_1
T2T-CHM13v2.01097,068,476 - 97,150,877 (-)NCBIT2T-CHM13v2.0
Blnk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391940,917,371 - 40,982,664 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1940,917,371 - 40,982,978 (-)EnsemblGRCm39 Ensembl
GRCm381940,928,927 - 40,994,221 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1940,928,927 - 40,994,535 (-)EnsemblGRCm38mm10GRCm38
MGSCv371941,003,417 - 41,069,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361940,982,238 - 41,047,846 (-)NCBIMGSCv36mm8
Celera1941,731,720 - 41,797,451 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1934.26NCBI
Blnk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,703,064 - 249,770,533 (-)NCBIGRCr8
mRatBN7.21239,753,640 - 239,821,113 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1239,753,648 - 239,821,113 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,895,953 - 247,963,478 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01254,593,052 - 254,660,575 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,246,078 - 247,313,603 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01260,187,023 - 260,254,490 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,186,967 - 260,254,600 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01267,630,219 - 267,697,917 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,091,335 - 246,165,075 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1235,596,883 - 235,664,334 (-)NCBICelera
Cytogenetic Map1q54NCBI
Blnk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555072,397,400 - 2,466,788 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555072,398,694 - 2,466,461 (-)NCBIChiLan1.0ChiLan1.0
BLNK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1289,622,438 - 9,700,335 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl289,622,752 - 9,732,639 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha289,807,140 - 9,884,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0289,893,624 - 9,971,969 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl289,893,992 - 9,971,860 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1289,602,489 - 9,652,695 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0289,662,351 - 9,745,957 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0289,805,622 - 9,883,362 (-)NCBIUU_Cfam_GSD_1.0
Blnk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721337,181,439 - 37,250,884 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366363,220,554 - 3,289,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366363,220,554 - 3,290,054 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BLNK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14107,625,803 - 107,715,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114107,630,477 - 107,715,421 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214117,265,086 - 117,349,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BLNK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1989,345,040 - 89,426,741 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl989,345,725 - 89,401,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604850,221,538 - 50,310,749 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Blnk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247377,565,169 - 7,681,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000057933   ⟹   ENSPPAP00000035047
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1096,316,103 - 96,391,067 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057936   ⟹   ENSPPAP00000035050
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1096,316,103 - 96,391,067 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057952   ⟹   ENSPPAP00000035067
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1096,319,259 - 96,390,878 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057958   ⟹   ENSPPAP00000035072
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1096,358,369 - 96,390,878 (-)Ensembl
RefSeq Acc Id: XM_003825406   ⟹   XP_003825454
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,096,234 - 108,178,190 (-)NCBI
NHGRI_mPanPan110108,101,552 - 108,183,485 (-)NCBI
Mhudiblu_PPA_v01092,803,408 - 92,885,129 (-)NCBI
PanPan1.11096,311,206 - 96,391,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003825407   ⟹   XP_003825455
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,096,234 - 108,178,188 (-)NCBI
NHGRI_mPanPan110108,101,552 - 108,183,485 (-)NCBI
Mhudiblu_PPA_v01092,805,116 - 92,885,130 (-)NCBI
PanPan1.11096,310,764 - 96,391,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034931222   ⟹   XP_034787113
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28108,097,658 - 108,231,100 (-)NCBI
NHGRI_mPanPan110108,102,920 - 108,236,505 (-)NCBI
Mhudiblu_PPA_v01092,805,051 - 92,936,868 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003825455   ⟸   XM_003825407
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C2L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003825454   ⟸   XM_003825406
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BZF9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034787113   ⟸   XM_034931222
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BZF9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000035072   ⟸   ENSPPAT00000057958
RefSeq Acc Id: ENSPPAP00000035067   ⟸   ENSPPAT00000057952
RefSeq Acc Id: ENSPPAP00000035047   ⟸   ENSPPAT00000057933
RefSeq Acc Id: ENSPPAP00000035050   ⟸   ENSPPAT00000057936
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040349 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057933.1 UniProtKB/TrEMBL
  ENSPPAT00000057936.1 UniProtKB/TrEMBL
  ENSPPAT00000057952.1 UniProtKB/TrEMBL
  ENSPPAT00000057958.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
NCBI Gene BLNK ENTREZGENE
PANTHER B-CELL LINKER PROTEIN UniProtKB/TrEMBL
  SH2 DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9BZF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BZH5_PANPA UniProtKB/TrEMBL
  A0A2R9BZI1_PANPA UniProtKB/TrEMBL
  A0A2R9C2L9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 BLNK  B cell linker    B-cell linker  Symbol and/or name change 5135510 APPROVED