| 2180 | Atp7b | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding; copper ion transmembrane transporter activity; zinc ion binding; INVOLVED IN cellular response to copper ion; cellular response to manganese ion; circadian rhythm; PARTICIPATES IN cisplatin drug pathway; ASSOCIATED WITH abnormal renal tubule morpho logy; decreased body weight; decreased circulating copper level; ASSOCIATED WITH liver carcinoma; Liver Neoplasms; renal adenoma; FOUND IN apical part of cell; basolateral plasma membrane; bicellular tight junction; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 16 | 76654725 | 76726092 | Rat | 410 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10217 | Atp7b | ATPase, copper transporting, beta polypeptide | Enables P-type divalent copper transporter activity. Acts upstream of or within several processes, including copper ion transport; intracellular monoatomic cation homeostasis; and lactation. Located in membrane and trans-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Wilson disease. Human ortholog(s) of this gene implicated in Wilson disease. Orthologous to human ATP7B (ATPase copper transporting beta). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 22482799 | 22550347 | Mouse | 447 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 731392 | ATP7B | ATPase copper transporting beta | This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-tr ansporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019] | 13 | 51932669 | 52012132 | Human | 1220 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8922156 | Atp7b | ATPase copper transporting beta | ENCODES a protein that exhibits ATP binding (ortholog); copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN cisplat in drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004955431 | 5228395 | 5297120 | Chinchilla | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11912572 | ATP7B | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | 13 | 33063698 | 33144528 | Bonobo | 124 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12299630 | ATP7B | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Wilson disease; Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | 22 | 162474 | 225599 | Dog | 127 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12623571 | Atp7b | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | NW_004936565 | 4694294 | 4763661 | Squirrel | 125 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918545 | Atp7b | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Naked Mole-Rat | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18488507 | ATP7B | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Green Monkey | 123 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625943771 | Atp7b | ATPase copper transporting beta | ENCODES a protein that exhibits ATP binding (ortholog); copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN cisplat in drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog) | | | | Black Rat | 94 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248163 | atp7b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13942918 | ATP7B | ATPase copper transporting beta | ENCODES a protein that exhibits copper ion binding (ortholog); copper ion transmembrane transporter activity (ortholog); zinc ion binding (ortholog); INVOLVED IN cellular response to copper ion (ortholog); cellular response to manganese ion (ortholog); circadian rhythm (ortholog); PARTICIPATES IN ci splatin drug pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Anhaptoglobinemia (ortholog); Animal Disease Models (ortholog); FOUND IN apical part of cell (ortholog); basolateral plasma membrane (ortholog); bicellular tight junction (ortholog); INTERACTS WITH 3',5'-cyclic AMP; colforsin daropate hydrochloride; copper atom | | | | Pig | 133 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155258680 | atp7b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243092 | atp7b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 11532742 | Atp7bhts | ATPase copper transporting beta; hepatitis | ASSOCIATED WITH abnormal renal tubule morphology; decreased body weight; decreased circulating copper level; ASSOCIATED WITH liver carcinoma; Liver Neoplasms; renal adenoma | | | | Rat | 18 | symbol , old_gene_symbol | gene, allele |
| 3051021 | ATP7BP1 | ATPase copper transporting beta pseudogene 1 | | 18 | 22418830 | 22419300 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1353842 | ATP13A3 | ATPase 13A3 | ATP13A3 is a member of the P-type ATPase family of proteins that transport a variety of cations across membranes. Other P-type ATPases include ATP7B (MIM 606882) and ATP7A (MIM 300011).[supplied by OMIM, Aug 2008] | 3 | 194402677 | 194494334 | Human | 141 | description | gene, protein-coding, VALIDATED [RefSeq] |