| 621293 | Atp2a1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding; calcium ion binding; calcium-dependent ATPase activity; INVOLVED IN calcium ion transmembrane transport; calcium ion transport; response to peptide hormone; PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; ASSOCIATED WITH Alcohol Myopathy; Cachexia; Experimental Diabetes Mellitus; FOUND IN sarcoplasmic reticulum; endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 2,6-di-tert-butyl-4-methylphenol; 3H-1,2-dithiole-3-thione | 1 | 190457198 | 190475410 | Rat | 250 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731640 | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is inv olved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013] | 16 | 28878488 | 28904466 | Human | 278 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1622417 | Atp2a1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | Enables calcium ion binding activity. Predicted to be involved in several processes, including calcium ion transport; intracellular calcium ion homeostasis; and regulation of striated muscle contraction. Predicted to act upstream of or within regulation of muscle contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including diaphragm; heart; limb mesenchyme; musculature; and sciatic nerve. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Jul 2025] | 7 | 126045032 | 126062245 | Mouse | 249 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8979912 | Atp2a1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); calcium ion import (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN calcium transpo rt pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); H zone (ortholog); I band (ortholog) | NW_004955493 | 6559995 | 6578461 | Chinchilla | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12327552 | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PAR TICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | 6 | 18384981 | 18400038 | Dog | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12656882 | Atp2a1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PAR TICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | NW_004936501 | 11818301 | 11836221 | Squirrel | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626124899 | Atp2a1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); calcium ion import (ortholog); calcium ion transmembrane transport (ortholog); PARTICIPATES IN calcium transpo rt pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); H zone (ortholog); I band (ortholog) | | | | Black Rat | 55 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13955616 | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PAR TICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | | | | Pig | 70 | symbol | gene, protein-coding, INFERRED [RefSeq] |
| 18458863 | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PAR TICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | | | | Green Monkey | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12035567 | ATP2A1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN calcium ion transport (ortholog); negative regulation of striated muscle contraction (ortholog); regulation of striated muscle contraction (ortholog); PAR TICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | | | | Bonobo | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155241960 | atp2a1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18907084 | Atp2a1 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 | ENCODES a protein that exhibits ATP binding (ortholog); calcium ion binding (ortholog); calcium-dependent ATPase activity (ortholog); INVOLVED IN apoptotic mitochondrial changes (ortholog); calcium ion import (ortholog); calcium ion transport (ortholog); PARTICIPATES IN calcium transport pathway; ca lcium/calcium-mediated signaling pathway; ASSOCIATED WITH Alcohol Myopathy (ortholog); Brody myopathy (ortholog); Cachexia (ortholog); FOUND IN H zone (ortholog); I band (ortholog); sarcoplasmic reticulum (ortholog) | | | | Naked Mole-Rat | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256628 | atp2a1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155241961 | atp2a1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 9588175 | ATP2A1-AS1 | ATP2A1 antisense RNA 1 | INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; acrylamide; aflatoxin B1 | 16 | 28878957 | 28879921 | Human | 9 | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |