| 1310631 | Atg16l1 | autophagy related 16-like 1 | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN dendrite arborization; negative regulation of dendrite extension; autophagosome assembly (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATE D WITH Cardiomegaly; Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN glutamatergic synapse; synapse; Atg12-Atg5-Atg16 complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene | 9 | 95869839 | 95905354 | Rat | 191 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1321647 | ATG16L1 | autophagy related 16 like 1 | The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Severa l transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] | 2 | 233251673 | 233295669 | Human | 184 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553543 | Atg16l1 | autophagy related 16 like 1 | Enables identical protein binding activity. Involved in several processes, including autophagosome assembly; axonal transport; and defense response to virus. Acts upstream of or within macroautophagy; negative stranded viral RNA replication; and telencephalon development. Located in several cellular components, including autophagosome membrane; phagophore assembly site membrane; and sperm midpiece. Part of Atg12-Atg5-Atg16 complex. Is active in glutamatergic synapse. Is expressed in central nervous system and retina. Used to study inflammatory bowel disease 10. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to human ATG16L1 (autophagy related 16 like 1). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 87683730 | 87720150 | Mouse | 264 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8945673 | Atg16l1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); axonal transport (ortholog); C-terminal protein lipidation (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN Atg12-Atg5-Atg16 complex (ortholog); autophagosome (ortholog); autophagosome membrane (ortholog) | NW_004955453 | 2884497 | 2917581 | Chinchilla | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12003278 | ATG16L1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (inferred); identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); dendrite arborization (ortholog); PARTICIPATES IN autophagy pat hway; ASSOCIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN synapse (ortholog) | 2B | 120479534 | 120523563 | Bonobo | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12114183 | ATG16L1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (inferred); identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); dendrite arborization (ortholog); PARTICIPATES IN autophagy pat hway; ASSOCIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN synapse (ortholog) | 25 | 44761034 | 44800033 | Dog | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12677959 | Atg16l1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (inferred); identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); dendrite arborization (ortholog); PARTICIPATES IN autophagy pat hway; ASSOCIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN synapse (ortholog) | NW_004936525 | 3973574 | 4010442 | Squirrel | 85 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18655287 | ATG16L1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (inferred); identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); dendrite arborization (ortholog); PARTICIPATES IN autophagy pat hway; ASSOCIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN synapse (ortholog) | | | | Green Monkey | 87 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155231229 | atg16l1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625972068 | Atg16l1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); protein-membrane adaptor activity (ortholog); INVOLVED IN autophagosome assembly (ortholog); axonal transport (ortholog); C-terminal protein lipidation (ortholog); PARTICIPATES IN autophagy pathway; ASSO CIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN Atg12-Atg5-Atg16 complex (ortholog); autophagosome (ortholog); autophagosome membrane (ortholog) | | | | Black Rat | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14126579 | ATG16L1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (inferred); identical protein binding (inferred); protein-membrane adaptor activity (inferred); INVOLVED IN C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); dendrite arborization (ortholog); PARTICIPATES IN autophagy pat hway; ASSOCIATED WITH Cardiomegaly (ortholog); Crohn's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN synapse (ortholog); INTERACTS WITH cadmium atom | | | | Pig | 86 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18902462 | Atg16l1 | autophagy related 16 like 1 | ENCODES a protein that exhibits GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN axonal transport (ortholog); C-terminal protein lipidation (ortholog); corpus callosum development (ortholog); PARTICIPATES IN autophagy pathway; ASSOCIATED WITH Cardiomegaly (ortholog); Croh n's disease (ortholog); inflammatory bowel disease (ortholog); FOUND IN autophagosome (ortholog); autophagosome membrane (ortholog); axoneme (ortholog) | | | | Naked Mole-Rat | 72 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155260108 | atg16l1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155231230 | atg16l1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 149735571 | Atg16l1em8Rrrc | autophagy related 16-like 1; CRISPR/Cas9 induced mutant 8, RRRC | CRISPR-Cas9-mediated knock-in of a single base pair polymorphism of guanine to alanine in exon 10, resulting in a threonine to alanine substitution at amino acid position 299 in the rat. Mimics the same nucleotide substitution for the threonine to alanine substitution at amino acid position 300 in h umans (T300A), Homozygosity for this allele is embryonic lethal. | | | | Rat | | symbol | gene, allele |