| 1347917 | ASCC2 | activating signal cointegrator 1 complex subunit 2 | Enables K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of DNA repair complex and RQC-trigger c omplex. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Jul 2025] | 22 | 29788611 | 29838274 | Human | 90 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1561422 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); rescue of stalled cytosolic ribosome (ortholog); ribosome disassembly (ortholog); FOUND IN cytosolic ribosome (ortholog); nucl eus (ortholog); RQC-trigger complex (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 14 | 83726975 | 83771312 | Rat | 85 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1623910 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predi cted to be located in nucleus. Predicted to be part of DNA repair complex and RQC-trigger complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including adrenal gland; alimentary system; aorta; brain; and genitourinary system. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 4587698 | 4635699 | Mouse | 104 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8756821 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); rescue of stalled cytosolic ribosome (ortholog); ribosome disassembly (ortholog); FOUND IN cytosolic ribosome (ortholog); DNA repair complex (ortholog); nucleus (ortholog) | NW_004955455 | 4032357 | 4077900 | Chinchilla | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11738592 | ASCC2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled cytosolic ribosome (inferred); ribosome disassembly (inferred); FOUND IN cytos olic ribosome (inferred); nucleus (inferred); RQC-trigger complex (inferred) | 22 | 10832102 | 10881987 | Bonobo | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12257619 | ASCC2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled cytosolic ribosome (inferred); ribosome disassembly (inferred); FOUND IN cytos olic ribosome (inferred); nucleus (inferred); RQC-trigger complex (inferred) | 26 | 22967880 | 23009600 | Dog | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12509890 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled cytosolic ribosome (inferred); ribosome disassembly (inferred); FOUND IN cytos olic ribosome (inferred); nucleus (inferred); RQC-trigger complex (inferred) | NW_004936657 | 3709578 | 3752377 | Squirrel | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18930811 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN rescue of stalled cytosolic ribosome (ortholog); ribosome disassembly (ortholog); ribosome-associated ubiquitin-dependent protein catabolic process (ortholog); FOUND IN cytosolic r ibosome (ortholog); DNA repair complex (ortholog); nucleus (ortholog) | | | | Naked Mole-Rat | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14118186 | ASCC2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled cytosolic ribosome (inferred); ribosome disassembly (inferred); FOUND IN cytos olic ribosome (inferred); nucleus (inferred); RQC-trigger complex (inferred) | | | | Pig | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626027742 | Ascc2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); rescue of stalled cytosolic ribosome (ortholog); ribosome disassembly (ortholog); FOUND IN cytosolic ribosome (ortholog); DNA repair complex (ortholog); nucleus (ortholog) | | | | Black Rat | 12 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18746649 | ASCC2 | activating signal cointegrator 1 complex subunit 2 | ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (inferred); ubiquitin binding (inferred); INVOLVED IN regulation of DNA-templated transcription (inferred); rescue of stalled cytosolic ribosome (inferred); ribosome disassembly (inferred); FOUND IN cytos olic ribosome (inferred); nucleus (inferred); RQC-trigger complex (inferred) | | | | Green Monkey | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253766 | ascc2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155253767 | ascc2.S | | | | | | African Clawed Frog | | symbol | gene, null |