Ascc2 (activating signal cointegrator 1 complex subunit 2) - Rat Genome Database

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Gene: Ascc2 (activating signal cointegrator 1 complex subunit 2) Chinchilla lanigera
Analyze
Symbol: Ascc2
Name: activating signal cointegrator 1 complex subunit 2
RGD ID: 8756821
Description: ENCODES a protein that exhibits K63-linked polyubiquitin modification-dependent protein binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); rescue of stalled ribosome (ortholog); ribosome disassembly (ortholog); ASSOCIATED WITH Breast Cancer, Familial (ortholog); genetic disease (ortholog); vestibular schwannomatosis (ortholog); FOUND IN activating signal cointegrator 1 complex (ortholog); cytosolic ribosome (ortholog); DNA repair complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,032,194 - 4,077,953 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ascc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,032,194 - 4,077,953 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBIChiLan1.0ChiLan1.0
ASCC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382229,788,611 - 29,838,274 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2229,788,609 - 29,838,304 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,184,600 - 30,234,263 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,514,600 - 28,564,254 (-)NCBINCBI36Build 36hg18NCBI36
Build 342228,509,155 - 28,558,808NCBI
Celera2213,984,318 - 14,033,974 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,146,838 - 13,196,327 (-)NCBIHuRef
CHM1_12230,143,775 - 30,193,418 (-)NCBICHM1_1
T2T-CHM13v2.02230,251,982 - 30,301,644 (-)NCBIT2T-CHM13v2.0
Ascc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,587,698 - 4,635,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,587,747 - 4,635,699 (+)EnsemblGRCm39 Ensembl
GRCm38114,637,696 - 4,685,699 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,637,747 - 4,685,699 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,537,796 - 4,583,388 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,537,796 - 4,583,388 (+)NCBIMGSCv36mm8
Celera115,138,813 - 5,181,677 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Ascc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,726,975 - 83,771,312 (+)NCBIGRCr8
mRatBN7.21479,503,449 - 79,547,801 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,503,517 - 79,545,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,934,172 - 83,976,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01485,174,233 - 85,216,197 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,623,865 - 81,665,862 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,873,507 - 84,913,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,876,781 - 84,913,617 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,550,450 - 85,592,750 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41485,277,839 - 85,320,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1478,409,997 - 78,452,215 (+)NCBICelera
Cytogenetic Map14q21NCBI
ASCC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22339,760,257 - 39,810,219 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,461,579 - 42,511,511 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02210,832,102 - 10,881,987 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12228,637,041 - 28,686,019 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2228,637,041 - 28,686,003 (-)Ensemblpanpan1.1panPan2
ASCC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,967,880 - 23,009,600 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,970,222 - 23,004,731 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,838,835 - 22,880,563 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,341,402 - 23,383,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,341,404 - 23,383,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,051,584 - 23,093,413 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,314,145 - 23,355,874 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,373,924 - 23,415,658 (-)NCBIUU_Cfam_GSD_1.0
Ascc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,118,251 - 112,161,111 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366573,707,721 - 3,752,499 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366573,709,578 - 3,752,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASCC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,797,317 - 46,842,459 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,797,307 - 46,842,479 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,832,165 - 49,879,613 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASCC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11912,673,642 - 12,725,268 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1912,673,064 - 12,725,233 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045113,421,058 - 113,472,673 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ascc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247476,105,753 - 6,149,987 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247476,103,219 - 6,150,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000012134   ⟹   ENSCLAP00000011993
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554554,032,194 - 4,077,953 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000012135   ⟹   ENSCLAP00000011994
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554554,035,003 - 4,072,651 (-)Ensembl
RefSeq Acc Id: XM_005396225   ⟹   XP_005396282
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520428   ⟹   XP_013375882
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520429   ⟹   XP_013375883
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554554,032,357 - 4,077,900 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520430   ⟹   XP_013375884
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554554,032,357 - 4,065,172 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520431   ⟹   XP_013375885
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554554,032,357 - 4,065,191 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005396282   ⟸   XM_005396225
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VCJ1 (UniProtKB/TrEMBL),   A0A8C2VF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375883   ⟸   XM_013520429
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375882   ⟸   XM_013520428
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375885   ⟸   XM_013520431
- Peptide Label: isoform X5
- UniProtKB: A0A8C2VF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013375884   ⟸   XM_013520430
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VF28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000011993   ⟸   ENSCLAT00000012134
RefSeq Acc Id: ENSCLAP00000011994   ⟸   ENSCLAT00000012135
Protein Domains
CUE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008277 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000012134 ENTREZGENE
  ENSCLAT00000012134.1 UniProtKB/TrEMBL
  ENSCLAT00000012135.1 UniProtKB/TrEMBL
Gene3D-CATH DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro ASCC2_CUE UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene Ascc2 ENTREZGENE
PANTHER ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 UniProtKB/TrEMBL
  ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100 UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
UniProt A0A8C2VCJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VF28 ENTREZGENE, UniProtKB/TrEMBL