| 62058 | Aoc3 | amine oxidase, copper containing 3 | ENCODES a protein that exhibits identical protein binding; primary methylamine oxidase activity; calcium ion binding (ortholog); INVOLVED IN eating behavior; leukocyte migration involved in inflammatory response; positive regulation of acute inflammatory response; PARTICIPATES IN beta-alanine metabo lic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; ASSOCIATED WITH aortic aneurysm; Choroidal Neovascularization; Experimental Arthritis; FOUND IN extracellular space; cell surface (ortholog); cytoplasm (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 10 | 86773018 | 86780961 | Rat | 198 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 62350 | Aoc3 | amine oxidase, copper containing 3 | Predicted to enable several functions, including identical protein binding activity; metal ion binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regu lation of D-glucose transmembrane transport. Predicted to be located in several cellular components, including cell surface; extracellular space; and microvillus. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; axial skeleton; cardiovascular system; sensory organ; and skin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 101221432 | 101230256 | Mouse | 236 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1347849 | AOC3 | amine oxidase copper containing 3 | This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as mono amine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] | 17 | 42851199 | 42858124 | Human | 198 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 12295518 | AOC3 | amine oxidase copper containing 3 | ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); primary methylamine oxidase activity (ortholog); INVOLVED IN cell adhesion (ortholog); eating behavior (ortholog); leukocyte migration involved in inflammatory response (ortholog); PARTICIPATES IN b eta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); aortic aneurysm (ortholog); cerebral amyloid angiopathy (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); early endosome (ortholog) | 9 | 20158581 | 20179773 | Dog | 68 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 152178057 | AOC3 | amine oxidase copper containing 3 | | | | | Naked Mole-Rat | | symbol | gene, protein-coding |
| 155234763 | aoc3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626080171 | Aoc3 | amine oxidase copper containing 3 | ENCODES a protein that exhibits calcium ion binding (ortholog); copper ion binding (ortholog); identical protein binding (ortholog); INVOLVED IN amine metabolic process (ortholog); cell adhesion (ortholog); eating behavior (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; carnosinemia path way; GABA aminotransferase deficiency pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); aortic aneurysm (ortholog); cerebral amyloid angiopathy (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); early endosome (ortholog) | | | | Black Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18546922 | AOC3 | amine oxidase copper containing 3 | ENCODES a protein that exhibits identical protein binding (ortholog); primary methylamine oxidase activity (ortholog); INVOLVED IN eating behavior (ortholog); leukocyte migration involved in inflammatory response (ortholog); positive regulation of acute inflammatory response (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); aortic aneurysm (ortholog); cerebral amyloid angiopathy (ortholog); FOUND IN extracellular space (ortholog) | | | | Green Monkey | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155242315 | aoc3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861913 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405861235 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626182885 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862981 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626187434 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864985 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626179809 | aoc3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14216347 | LOC100520329 | membrane primary amine oxidase | ENCODES a protein that exhibits copper ion binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN amine metabolic process (inferred); inflammatory response (inferred) | | | | Pig | 16 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 11721286 | LOC100973737 | membrane primary amine oxidase | ENCODES a protein that exhibits calcium ion binding (inferred); copper ion binding (inferred); identical protein binding (inferred); INVOLVED IN amine metabolic process (inferred); cell adhesion (inferred); inflammatory response (inferred); FOUND IN cell surface (inferred); cytoplasm (inferred); ear ly endosome (inferred) | 17 | 14459737 | 14466946 | Bonobo | 34 | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918526 | LOC101709673 | membrane primary amine oxidase | ENCODES a protein that exhibits calcium ion binding (inferred); copper ion binding (inferred); identical protein binding (inferred); INVOLVED IN amine metabolic process (inferred); cell adhesion (inferred); inflammatory response (inferred); FOUND IN cell surface (inferred); cytoplasm (inferred); ear ly endosome (inferred) | | | | Naked Mole-Rat | 35 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12571157 | LOC101973421 | amine oxidase copper containing 3 | ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); primary methylamine oxidase activity (ortholog); INVOLVED IN cell adhesion (ortholog); eating behavior (ortholog); leukocyte migration involved in inflammatory response (ortholog); PARTICIPATES IN b eta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); aortic aneurysm (ortholog); cerebral amyloid angiopathy (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); early endosome (ortholog) | NW_004936490 | 17549836 | 17564867 | Squirrel | 71 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 8803891 | LOC102026281 | membrane primary amine oxidase | | NW_004955451 | 16644224 | 16649957 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 12338126 | WNK4 | WNK lysine deficient protein kinase 4 | ENCODES a protein that exhibits ATP binding (inferred); chloride ion binding (inferred); copper ion binding (inferred); INVOLVED IN aldosterone secretion (inferred); amine metabolic process (inferred); calcium ion homeostasis (inferred); FOUND IN bicellular tight junction (inferred); cell body (infe rred); cytoplasm (inferred) | 9 | 20224726 | 20241214 | Dog | 53 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
