| 2120 | Anxa5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding; identical protein binding; P-type calcium transporter activity; INVOLVED IN cellular response to gonadotropin-releasing hormone; cellular response to lead ion; negative regulation of blood coagulation; ASSOCIATED WITH Cardiomega ly; cryptorchidism; glomerulonephritis; FOUND IN axon terminus; cell projection; dendrite; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol | 2 | 121242133 | 121272935 | Rat | 351 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 734268 | ANXA5 | annexin A5 | The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which ha ve been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019] | 4 | 121667946 | 121696980 | Human | 360 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 734269 | Anxa5 | annexin A5 | Enables phosphatidylserine binding activity. Predicted to be involved in several processes, including cellular response to gonadotropin-releasing hormone; negative regulation of prolactin secretion; and regulation of flagellated sperm motility. Located in endothelial microparticle and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). [provided by Alliance of Genome Resources, Jul 2025] | 3 | 36503072 | 36530036 | Mouse | 375 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9022218 | Anxa5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | NW_004955428 | 18873782 | 18907955 | Chinchilla | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11741738 | ANXA5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | 4 | 113868218 | 113897243 | Bonobo | 83 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12374412 | ANXA5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | 19 | 18419936 | 18450088 | Dog | 81 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12668812 | Anxa5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | NW_004936662 | 926302 | 959964 | Squirrel | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253297 | anxa5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625853431 | Anxa5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | | | | Black Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18913413 | Anxa5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18707888 | ANXA5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog) | | | | Green Monkey | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13870231 | ANXA5 | annexin A5 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); identical protein binding (ortholog); P-type calcium transporter activity (ortholog); INVOLVED IN cellular response to gonadotropin-releasing hormone (ortholog); cellular response to lead ion (ortholog); negative regu lation of blood coagulation (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Alzheimer's disease (ortholog); autoimmune disease of the nervous system (ortholog); FOUND IN axon terminus (ortholog); cell projection (ortholog); dendrite (ortholog); INTERACTS WITH linoleic acid; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine; ochratoxin A | | | | Pig | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243527 | anxa5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155236604 | anxa5.S | | | | | | African Clawed Frog | | symbol | gene, null |