| 1309620 | Ank1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cytoskeletal anchor activity (ortholog); enzyme binding (ortholog); INVOLVED IN positive regulation of organelle organization; endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); erythrocyte development (ortholog); ASSOCIAT ED WITH Myocardial Reperfusion Injury; transient cerebral ischemia; anemia (ortholog); FOUND IN A band; axolemma; M band; INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine | 16 | 75578824 | 75757464 | Rat | 215 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1320055 | ANK1 | ankyrin 1 | Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with d ifferent affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008] | 8 | 41653225 | 41896741 | Human | 557 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1320056 | Ank1 | ankyrin 1, erythroid | Predicted to enable several functions, including enzyme binding activity; spectrin binding activity; and transmembrane transporter binding activity. Acts upstream of or within several processes, including erythrocyte development; multicellular organismal-level iron ion homeostasis; and porphyrin-con taining compound biosynthetic process. Located in cortical cytoskeleton; membrane; and spectrin-associated cytoskeleton. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; retina; and skeletal muscle. Used to study hereditary spherocytosis type 1 and malaria. Human ortholog(s) of this gene implicated in anemia; hereditary spherocytosis; and hereditary spherocytosis type 1. Orthologous to human ANK1 (ankyrin 1). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 23464852 | 23640517 | Mouse | 395 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8970793 | Ank1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cytoskeletal anchor activity (ortholog); enzyme binding (ortholog); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (or tholog); ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); ankyrin-1 complex (ortholog); axolemma (ortholog) | NW_004955536 | 1049325 | 1237943 | Chinchilla | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11981073 | ANK1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal anchor activity (inferred); enzyme binding (inferred); INVOLVED IN erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); porphyrin-containing compound biosynthetic process (ortholog) ; ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); axolemma (ortholog); cortical cytoskeleton (ortholog) | 8 | 40897879 | 41140290 | Bonobo | 64 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12093199 | ANK1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal anchor activity (inferred); enzyme binding (inferred); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport; protein localization to plasma membrane; erythrocyte development (ortholog); ASSOCIATED WITH anemia (o rtholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN cytosol; A band (ortholog); axolemma (ortholog); INTERACTS WITH mocetinostat | 16 | 23858299 | 23966181 | Dog | 65 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12635006 | Ank1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal anchor activity (inferred); enzyme binding (inferred); INVOLVED IN erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); porphyrin-containing compound biosynthetic process (ortholog) ; ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); axolemma (ortholog); cortical cytoskeleton (ortholog) | NW_004936785 | 738323 | 944734 | Squirrel | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238814 | ank1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626001795 | Ank1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cytoskeletal anchor activity (ortholog); enzyme binding (ortholog); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (or tholog); ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); ankyrin-1 complex (ortholog); axolemma (ortholog) | | | | Black Rat | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13951416 | ANK1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal anchor activity (inferred); enzyme binding (inferred); INVOLVED IN erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); porphyrin-containing compound biosynthetic process (ortholog) ; ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); axolemma (ortholog); cortical cytoskeleton (ortholog) | | | | Pig | 62 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927154 | Ank1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (ortholog); cytoskeletal anchor activity (ortholog); enzyme binding (ortholog); INVOLVED IN endoplasmic reticulum to Golgi vesicle-mediated transport (ortholog); erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (or tholog); ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); ankyrin-1 complex (ortholog); axolemma (ortholog) | | | | Naked Mole-Rat | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18750943 | ANK1 | ankyrin 1 | ENCODES a protein that exhibits ATPase binding (inferred); cytoskeletal anchor activity (inferred); enzyme binding (inferred); INVOLVED IN erythrocyte development (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); porphyrin-containing compound biosynthetic process (ortholog) ; ASSOCIATED WITH anemia (ortholog); bone development disease (ortholog); genetic disease (ortholog); FOUND IN A band (ortholog); axolemma (ortholog); cortical cytoskeleton (ortholog) | | | | Green Monkey | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155248314 | ank1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155259139 | ank1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16559732 | AC113133.1 | novel transcript, antisense to ANK1 | | | | | Human | | name | gene, lncrna |
